1H47


Conserved Protein Domain Family
ispF

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TIGR00151: ispF 
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2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Members of this protein family are 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, the IspF protein of the deoxyxylulose (non-mevalonate) pathway of IPP biosynthesis. This protein occurs as an IspDF bifunctional fusion protein in about 20 percent of bacterial genomes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Statistics
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PSSM-Id: 129255
Aligned: 16 rows
Threshold Bit Score: 207.913
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1H47_A   4 RIGHGFDVHAFGGEGPIIIGGVRIpYEK-GLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREA 82  Escherichia coli
O67089   4 RIGFGFDSHEFVEGKLLILGGVEI-EKDyGLKGHSDGDALLHAITDAILGALGERDIGEIFKDTDPRWKNAPSRIFLEKA 82  Aquifex aeolicus VF5
Q9RXS6   7 RIGYGEDAHRLAPGLPLVLGGVAIpHAElGAVAHSDGDAVLHAVADALLSGLALGDIGQYFPDTAAEWKGMDSRRILAKA 86  Deinococcus radiodura...
Q9A7I5 226 RVGQGFDAHRWGPGEEVWLCGVAIkHDE-TLVGHSDADAGLHALTDAILGAIGEGDIGDHFPPTDPKWKGAASDQFLKHA 304 Caulobacter crescentu...
P96863   6 RVGLGTDVHPIEPGRPCWLVGLLFpSAD-GCAGHSDGDVAVHALCDAVLSAAGLGDIGEVFGVDDPRWQGVSGADMLRHV 84  Mycobacterium tubercu...
Q9PDT5  16 RIGQGYDVHAFGPGDHVMLGGVRVpHRC-GVLAHSDGDVILHALCDAMLGALGLGDIGQHFPPSDVRWKGADSGVFVRHC 94  Xylella fastidiosa 9a5c
Q8XI08   2 RIGMGYDVHKLVENRDLILGGVKIpYEK-GLLGHSDADVLLHAIMDSLLGAAALGDIGKHFPDTDPKYKGADSIKLLEFV 80  Clostridium perfringe...
Q8R6E7   3 RIGNGYDVHKLVEGRKLMLGGVEVpHTK-GVLGHSDGDVLLHAITDAIIGALGLGDIGLHFPDNDENLKDIDSAILLKKI 81  Fusobacterium nucleat...
P73426   5 RIGNGYDIHRLVGDRPLILGGVTIaHHL-GLDGHSDADVLTHALMDALLGALSLGDIGHYFPPSDARWQGADSLKLLAQV 83  Synechocystis sp. PCC...
P57494   2 RIGYGFDLHAFGSTKPLIIGGVLIpCEK-GLIAHSNGDLLIHSLIDALLGATAMGDIGSFFPSNNYIYKNIDSRILLKKI 80  Buchnera aphidicola s...
1H47_A  83 WRRIQAkGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEklGFTgRGEGIACEAVALLIK 158 Escherichia coli
O67089  83 LEVMSEkGFNISNIDCVIVADRPKIAPHKERIKESLSKLLGIPKERISLKGKRRE--GFC-EGNGLVCMCTVLLVK 155 Aquifex aeolicus VF5
Q9RXS6  87 LELVEErGYRPVNVALVVTLDRPKLGPLRADIAASVAELLGLPAGEVGVSFKTSE--GLA--LEHVQTRVTVLLGR 158 Deinococcus radiodurans R1
Q9A7I5 305 VDLVTAkGGALVNVDVTLICERPKIKPHRQAMRERLAEILSIPVDRVSVKATTTEkmGFTgRGEGLAASAVVAVET 380 Caulobacter crescentus CB15
P96863  85 VVLITQhGYRVGNAVVQVIGNRPKIGWRRLEAQAVLSRLLNAP---VSVSATTTDglGLTgRGEGLAAIATALVVS 157 Mycobacterium tuberculosis
Q9PDT5  95 HLLLRErDWCVGNVDATAICESPKIAPYVNAMREGIARLLEVQPECVSVKATTSEglGFIgRGEGLAAQVVVLLYR 170 Xylella fastidiosa 9a5c
Q8XI08  81 GELLNKnNYKISNIDATIIAQRPKMAPHIPTMRENIAKALNIDLDQINVKATTEEglGFTgSGEGISSQSICLLVK 156 Clostridium perfringens s...
Q8R6E7  82 NNIMKEkNYKIVNLDSIIVMQKPKLRPYIDSIRDNIAKILEINSELINVKAKTEEklGFTgDETGVKSYCVVLLEK 157 Fusobacterium nucleatum s...
P73426  84 HQLILErGWRINNLDNVIVAEQPKLKPHIQAMKENLAKVLTIDPDLIGIKATTNErlGPTgREEGIAAYSVALLIK 159 Synechocystis sp. PCC 680...
P57494  81 WNKIILlNYDICNIDITIIAEYPKMLPYIFFMRSNLSLDLNTEIDNISIKSTTSKkiGCIgRKEAIACHSIVMLIK 156 Buchnera aphidicola str. ...
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