1RVV,3MK3,1EJB


Conserved Protein Domain Family
lumazine-synth

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TIGR00114: lumazine-synth 
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6,7-dimethyl-8-ribityllumazine synthase
This enzyme catalyzes the cyclo-ligation of 3,4-dihydroxy-2-butanone-4-P and 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 6,7-dimethyl-8-ribityllumazine, the immediate precursor of riboflavin. Sometimes referred to as riboflavin synthase, beta subunit, this should not be confused with the alpha subunit which carries out the subsequent reaction. Archaeal members of this family are considered putative, although included in the seed and scoring above the trusted cutoff. [Biosynthesis of cofactors, prosthetic groups, and carriers, Riboflavin, FMN, and FAD]
Statistics
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PSSM-Id: 211550
Aligned: 13 rows
Threshold Bit Score: 169.466
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RVV_A    13 LKIGIVVGRFNDFITSKLLSGAEDALLRHGVDTN----DIDVAWVPGAFEIPFAAKKMAETKK-----YDAIITLGTVIR 83  Bacillus subtilis s...
P25540    13 ARVAITIARFNNFINDSLLEGAIDALKRIGQVKDe---NITVVWVPGAYELPLAAGALAKTGK-----YDAVIALGTVIR 84  Escherichia coli
O24854    14 ERVAILTSRFNHIITDRLQEGAMDCFKRHGGDED----LLDIVLVPGAYELPFILDKLLESEK-----YDGVCVLGAIIR 84  Helicobacter pylori...
P11998    13 LKIGIVVGRFNDFITSKLLSGAEDALLRHGVDTN----DIDVAWVPGAFEIPFAAKKMAETKK-----YDAIITLGTVIR 83  Bacillus subtilis s...
P73527    15 FRFALVIARFNDLVTEKLLSGCQDCLKRHGIDVDpagtQVDYIWVPGSFEVPLVTRKLAVSGQ-----YDAIICLGAVIR 89  Synechocystis sp. P...
Q8NQ53    17 LKVAVVTARWNAEICDRLHKHAVDAGRAAGATVS-------EYRVIGALELPVVVQELART-------HDAVVALGCVVR 82  Corynebacterium glu...
Q57751     5 VNLGFVIAEFNRDITYMMEKVAEEHAEFLGATVK------YKIVVPGVFDMPLAVKKLLEKDD-----VDAVVTIGCVIE 73  Methanocaldococcus ...
O28152     4 VKLGMVVAEFNRDITYMMEILGKEHAEFLGAEVS------EVIRVPGTFDIPIAVKKMLEKGR-----VDAVVAIGCVIE 72  Archaeoglobus fulgi...
O27443     4 VRIGAVVAEFNYDITHMMLELAKEHARFLDAEIT------RVIAVPGVFDMPLAVKKLLLEDE-----IDAVITLGAVIE 72  Methanothermobacter...
AAC22950  29 AKVAVVIARFNSFINESLLEGAIDALKRIGQVKDe---NITIVRTPGAYELPLVARRLAESKK-----FDAIVALGTVIR 100 Haemophilus influen...
P50861    18 IRVGIIHARWNRVIIDALVKGAIERMASLGVEEN----NIIIETVPGSYELPWGTKRFVDRQAklgkpLDVVIPIGVLIK 93  Saccharomyces cerev...
3MK3_A    13 ARVAITIARFNQFINDSLLDGAVDALTRIGQVKDd---NITVVWVPGAYELPLATEALAKSGK-----YDAVVALGTVIR 84  Salmonella enterica...
1EJB_A    17 IRVGIIHARWNRVIIDALVKGAIERMASLGVEEN----NIIIETVPGSYELPWGTKRFVDRQAklgkpLDVVIPIGVLIK 92  baker's yeast
1RVV_A    84 GATTHYDYVCNEAAKGIAQAANTTGVPVIFGIVTTENIEQAIERAGTKAG----NKGVDCAVSAIEMANLN 150 Bacillus subtilis subsp. sub...
P25540    85 GGTAHFEYVAGGASNGLAHVAQDSEIPVAFGVLTTESIEQAIERAGTKAG----NKGAEAALTALEMINVL 151 Escherichia coli
O24854    85 GGTPHFDYVSAEATKGIAHAMLKYSMPVSFGVLTTDNIEQAIERAGSKAG----NKGFEAMSTLIELLSLC 151 Helicobacter pylori 26695
P11998    84 GATTHYDYVCNEAAKGIAQAANTTGVPVIFGIVTTENIEQAIERAGTKAG----NKGVDCAVSAIEMANLN 150 Bacillus subtilis subsp. sub...
P73527    90 GQTPHFDFVAGEAAKGIAAIASQTGVPVIFGILTTDTMQQALERAGIKS-----NHGWGYAMNALEMASLM 155 Synechocystis sp. PCC 6803 s...
Q8NQ53    83 GGTPHFDYVCDSVTEGLTRIALDTSTPIGNGVLTTNTEEQAVERSGGEGSv--eDKGAEAMVAALDTALVL 151 Corynebacterium glutamicum A...
Q57751    74 GETEHDEIVVHNAARKIADLALQYDKPVTLGISGPGMTRLQAQERVDYG-----KRAVEAAVKMVKRLKAL 139 Methanocaldococcus jannaschi...
O28152    73 GETEHDEIVAQHAARKIMDLSLEYGKPVTLGISGPGMGRIAATERVDYA-----KRAVEAAVKLVKRLKEY 138 Archaeoglobus fulgidus DSM 4304
O27443    73 GATDHDQIVVQHASRKIADLALDYDKPVALGISGPGMTRLEAHQRVDYA-----KRAVEAAVKMYRRLKED 138 Methanothermobacter thermaut...
AAC22950 101 GGTAHFEYVAGEASSGLGKVAMDAEIPVAFGVLTTENIEQAIERAGTKAG----NKGAEAALTALEMVNLI 167 Haemophilus influenzae Rd KW20
P50861    94 GSTMHFEYISDSTTHALMNLQEKVDMPVIFGLLTCMTEEQALARAGIDEAhsmhNHGEDWGAAAVEMAVKF 164 Saccharomyces cerevisiae S288c
3MK3_A    85 GGTAHFEYVAGGASNGLASVAQDSGVPVAFGVLTTESIEQAIERAGTKAG----NKGAEAALTALEMINVL 151 Salmonella enterica subsp. e...
1EJB_A    93 GSTMHFEYISDSTTHALMNLQEKVDMPVIFGLLTCMTEEQALARAGIDEAhsmhNHGEDWGAAAVEMAVKF 163 baker's yeast
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