2VGM


Conserved Protein Domain Family
pelota
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TIGR00111: pelota 
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mRNA surveillance protein pelota
This model describes the Drosophila protein Pelota, the budding yeast protein DOM34 which it can replace, and a set of closely related archaeal proteins. Members contain a proposed RNA binding motif. The meiotic defect in pelota mutants may be a complex result of a protein translation defect, as suggested in yeast by ribosomal protein RPS30A being a multicopy suppressor and by an altered polyribosome profile in DOM34 mutants rescued by RPS30A. This family is homologous to a family of peptide chain release factors. Pelota is proposed to act in protein translation. [Protein synthesis, Translation factors]
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Statistics
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PSSM-Id: 129217
Aligned: 5 rows
Threshold Bit Score: 461.978
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2VGM_A         4 ISLKKDSFNKGgaVITLLPEDKEDLFTVYQIVDKDD-ELIFKKKFTSKL--DEAGKKK-STDLVKLKIKVISEDFDMKDE 79  baker's yeast
CAA54375       4 ISLKKDSFNKGgaVITLLPEDKEDLFTVYQIVDKDD-ELIFKKKFTSKL--DEAGKKK-STDLVKLKIKVISEDFDMKDE 79  baker's yeast
WP_010877250   8 MRIVEEDEKNG--VIELVPETLDDLWHLSHIIEEGDlLSARTTRRIQDTsgEKIRSDRgVKKTFYLGIRVETVSFHIYTG 85  Methanothermoba...
Q57638         1 MKIIEEIPQKN--IIKLMPENLDDLWVLYNIIEEGDkIFAVTERRVQDKg-DVIRADRgAKRKMFLGIEVKNVEFDENTK 77  Methanocaldococ...
WP_010878340   1 MQIVEENLRDNegEIKLIPETLDDLWHLRFIIEKGDvVFATTKRASQSS--DKLRSDK-EMVTVRLGIEVEKVEFHRFAN 77  Archaeoglobus f...

2VGM_A        80 YLKYKGVTVTdesGAsnVDIPVGKYLSFTLDYVYPFTIIKQnFNKFMQKLLNEACNIEYKSDTAAVVLQEGIAHVCLVTS 159 baker's yeast
CAA54375      80 YLKYKGVTVTdesGAsnVDIPVGKYLSFTLDYVYPFTIIKQnFNKFMQKLLNEACNIEYKSDTAAVVLQEGIAHVCLVTS 159 baker's yeast
WP_010877250  86 RLRATGVIER---GPe-DLVPMGSHHTLEVKLNTPLRIQKEhWSRWTLKRLRMAVRASKNLKAIILVMEDDVAELGLIRQ 161 Methanothermoba...
Q57638        78 RVRILGTIIH---GP--DDVPLGSHHTIEIKPFDELSIEKN-WKKWQIERIKEAIESSKRPKVLVVVMDDEEADIFEVRD 151 Methanocaldococ...
WP_010878340  78 RLRVSGKIVA---GIe-ES----GYHTLNITVGKELSIIKK-WKPEQLERLRRAVEDSNRPEIVMLTIEEGYAVAGVLRQ 148 Archaeoglobus f...

2VGM_A       160 SSTILKQKIEYSMpKKK-RTtdvLKFDEKTEKFYKAIysaMKKDLNFdKLKTIILCSPGFYAKILMDKIFQYAEEEHNKK 238 baker's yeast
CAA54375     160 SSTILKQKIEYSMpKKK-RTtdvLKFDEKTEKFYKAIysaMKKDLNFdKLKTIILCSPGFYAKILMDKIFQYAEEEHNKK 238 baker's yeast
WP_010877250 162 YGVEYRGPITGHIpGKRiQQ---RDRGKLRREFYESI---VESLQKYgDLETIIIAGPGFYKSDFYDYLMERYPEIAKKA 235 Methanothermoba...
Q57638       152 YSIKEICSIKSHT-SKKlDY---KINEELKKEYYHEI---AKVLSEY-DVDNILVAGPGFAKNSFYNFISSQYPELKNKI 223 Methanocaldococ...
WP_010878340 149 WGVEEIFEERMGY-GKG--------MGDSRKEFFGEV---AAKLESF-DFKYLIVAGPGFAKNDFLDFLKERYPEMAKNA 215 Archaeoglobus f...

2VGM_A       239 ILDNkgmffiahCSTGYLQGINEVLKNPLYASKLQDTKYSKEIMVMDEFLLHLNKDDdKAWYGEKEVVKAAEYGAISYLL 318 baker's yeast
CAA54375     239 ILDNkgmffiahCSTGYLQGINEVLKNPLYASKLQDTKYSKEIMVMDEFLLHLNKDDdKAWYGEKEVVKAAEYGAISYLL 318 baker's yeast
WP_010877250 236 VLEN--------TGTGGRAGISEVLRKGTVERVSSEKRIASEIRNVNEFLEKLARDPdSVVYGKVEVMDAINMGAVEKLL 307 Methanothermoba...
Q57638       224 VVES--------ISTTSRAGLNEVIKRGIINRIYAESRVAKETQLIEKLLEEIAKKG-LAVYGIDEVKKALEYSAIDTLL 294 Methanocaldococ...
WP_010878340 216 VVVD--------VSSVGSRGFIEILKRRVVDKIVGEVRLAEEAEYIDRLLEGIAK-GeRVAYGLDEVREAHNYRAIEVLL 286 Archaeoglobus f...

2VGM_A       319 LTDKVlhsdniA---QREEYLKLMDSVESNGGKALVLSTLHSLGEELDQLTGIACILKYPL 376 baker's yeast
CAA54375     319 LTDKVlhsdniA---QREEYLKLMDSVESNGGKALVLSTLHSLGEELDQLTGIACILKYPL 376 baker's yeast
WP_010877250 308 VLDRV------V---SREDIEGYLDMVESMGGSVVLISSEHEGGKQLESLGGLAGILRFKI 359 Methanothermobacter thermautotroph...
Q57638       295 VSDSL------V---RNHEIEKIIDTTEEMGGKVVIVSSEHDAGKQLKALGGIAGLLRFPI 346 Methanocaldococcus jannaschii DSM ...
WP_010878340 287 VADEFl-----LeerEKWDVDGLLREVEESGGKVVIMSTEFEPGKRLMSLGGIAALLRFNV 342 Archaeoglobus fulgidus
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