2KDX


Conserved Protein Domain Family
hypA
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TIGR00100: hypA 
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hydrogenase nickel insertion protein HypA
CXXC-~12X-CXXC and genetically seems a regulatory protein. In Hpylori, hypA mutant abolished hydrogenase activity and decrease in urease activity. Nickel supplementation in media restored urease activity and partial hydrogenase activity. HypA probably involved in inserting Ni in enzymes. [Protein fate, Protein modification and repair]
Links
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Statistics
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PSSM-Id: 272906
Aligned: 9 rows
Threshold Bit Score: 126.335
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2KDX_A         3 MHEYSVVSSLIA-----LCEEHAKKNQAHKIERVVVGIGERSAMDKSLFVSAFETFREESLVCKdAILDIVDEKVELECK 77  Helicobacter py...
P24189         1 MHEITLCQRALE-----LIEQQAAKHGAKRVTGVWLKIGAFSCVETSSLAFCFDLVCRGSVAEG-CKLHLEEQEAECWCE 74  Escherichia coli
P37184         1 MHELSLCQSAVE-----IIQRQAEQHDVKRVTAVWLEIGALSCVEESAVRFSFEIVCHGTVAQG-CDLHIVYKPAQAWCW 74  Escherichia coli
P74263         1 MHEVSLMEQTLA-----IAIAQAEDHGASQIHRLTLRVGQQSGVVADALRFAFEVVRQNTMAAE-ARLEIEEIPVTCRCQ 74  Synechocystis s...
P73269         1 MHETD----MTKalimtIQDWFDQQVEKPQITKIHLLVGQFTCVEPVSLQFAFEVQTKQTFLNG-AELVIKDVPLVAYCH 75  Synechocystis s...
O28904         1 MHEMSFAEAIIR-----NVLRFAEEKQAKTVTSVRVRVGELLLINPEQLQFCFSVASKGTIAEG-AKLEISVERADIRCL 74  Archaeoglobus f...
O25539         1 MHEYSVVSSLIA-----LCEEHAKKNQAHKIERVVVGIGERSAMDKSLFVSAFETFREESLVCKdAILDIVDEKVELECK 75  Helicobacter py...
WP_010876420   4 VHELSMADAIVR-----TVIDAAEKNDAVEVLEVTVEIGQLTLLNPEQIEFMLDVLSEGTILEG-ARFNLEVVPVEIECE 77  Methanothermoba...
Q57667         1 MHELSYANAMLEailnsIKKEEEKGKKIKKVTEINLEVGELTFINVEQLKFAFEVIAEGTVCEG-AKINVEFIKPKCKCL 79  Methanocaldococ...

2KDX_A        78 DCSHVFKPNAldYG------VCEKCHSKNVIITQGNEMRLLSLEMLAE 119 Helicobacter pylori 26695
P24189        75 TCQQYVTLLTqrVR------RCPQCHGDMLQIVADDGLQIRRIEIDQE 116 Escherichia coli
P37184        75 DCSQVVEIHq-hDA------QCPLCHGERLRVDTGDSLIVKSIEVE-- 113 Escherichia coli
P74263        75 HCHENFQPEd-wIY------RCPHCDQISQTVMDGKQLELASLELS-- 113 Synechocystis sp. PCC 6803 substr. Kazusa
P73269        76 TCQTEYSPEIglQY------SCPTCRSPMDDIRSGRELKIDRIEHHQC 117 Synechocystis sp. PCC 6803 substr. Kazusa
O28904        75 LCGRELSKDe-mLC------EC---GGFA-QVKGGKDFILESVVVEV- 110 Archaeoglobus fulgidus DSM 4304
O25539        76 DCSHVFKPNAldYG------VCEKCHSKNVIITQGNEMRLLSLEMLAE 117 Helicobacter pylori
WP_010876420  78 CGYEGVVEAd-eLDhfapviKCPACGGHEFHVRAGRECNVKNIKIEKK 124 Methanothermobacter thermautotrophicus
Q57667        80 DCGYEGEPEI--LDef--evYCPKCKSIRLKLSGGKEFNIKNATVEYE 123 Methanocaldococcus jannaschii DSM 2661
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