1P9P


Conserved Protein Domain Family
trmD
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TIGR00088: trmD 
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tRNA (guanine-N1)-methyltransferase
This model is specfic for the tRNA modification enzyme tRNA (guanine-N1)-methyltransferase (trmD). This enzyme methylates guanosime-37 in a number of tRNAs.The enzyme's catalytic activity is as follows: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine. [Protein synthesis, tRNA and rRNA base modification]
Links
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Statistics
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PSSM-Id: 129196
Aligned: 9 rows
Threshold Bit Score: -1
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1P9P_A         7 MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAG- 85 
P43912         1 MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGe 80  Haemophilus inf...
O31741         1 MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDNKHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAa 80  Bacillus subtil...
P72828         1 MQFDVLTLFPDFFTSPLQSGLLGKALEKAIASVNLINPRDFTTDKHRRVDDEPYGGGVGMVIKPEPIFAAVESLPVLSKr 80  Synechocystis s...
O51641         1 MKFTVLSLFPAIIKPFFENSIMKKAINKGIVSFELVDVRDFSKDKHKRCDDLPYGGGAGMVLKAEPISFALEHVESAKK- 79  Borrelia burgdo...
P47683         1 MKITVLTLFENTIWPYLNSSIMLQAQKANLVQFEVVNWRNFCNDKHKTVDDMAYGGGSGMVLKAEPIINCLNFYKAPNS- 79  Mycoplasma geni...
O25766         1 MKFSVLTLFPQLVWPYFEDSILKRALEKNLFELEVLNLRDFSANKYQKADHTLIGGGAGQILDPEMVENALHSVKNPKH- 79  Helicobacter py...
WP_017532956   1 mkitvltlfeqvvwpylnasiMAQAQKAKLVEFEVINWRQYCKDKHQTVDDMAYGGGGGMVLKAEPILKALKACRTPQS- 79  Mycoplasma pneu...
P07020         1 MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGe 80  Escherichia coli
P43912         1 MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGe 80  Haemophilus inf...
O31741         1 MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDNKHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAa 80  Bacillus subtil...
P72828         1 MQFDVLTLFPDFFTSPLQSGLLGKALEKAIASVNLINPRDFTTDKHRRVDDEPYGGGVGMVIKPEPIFAAVESLPVLSKr 80  Synechocystis s...
O51641         1 MKFTVLSLFPAIIKPFFENSIMKKAINKGIVSFELVDVRDFSKDKHKRCDDLPYGGGAGMVLKAEPISFALEHVESAKK- 79  Borrelia burgdo...
P47683         1 MKITVLTLFENTIWPYLNSSIMLQAQKANLVQFEVVNWRNFCNDKHKTVDDMAYGGGSGMVLKAEPIINCLNFYKAPNS- 79  Mycoplasma geni...
O25766         1 MKFSVLTLFPQLVWPYFEDSILKRALEKNLFELEVLNLRDFSANKYQKADHTLIGGGAGQILDPEMVENALHSVKNPKH- 79  Helicobacter py...
WP_017532956   1 mkitvltlfeqvvwpylnasiMAQAQKAKLVEFEVINWRQYCKDKHQTVDDMAYGGGGGMVLKAEPILKALKACRTPQS- 79  Mycoplasma pneu...
P07020         1 MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGe 80  Escherichia coli

1P9P_A        86 --EgakVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIP 163
P43912        81 gaK---VIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIP 157 Haemophilus inf...
O31741        81 apR---IILVCPQGERFTQKKAEQLAKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLP 157 Bacillus subtil...
P72828        81 --E---VILMTPQGQPMDQALFRELTNYDQLVLICGHYEGVDERVCQ-LVTREVSLGDFVLTCGEIPALTLINGVIRLLP 154 Synechocystis s...
O51641        80 --T---TIFLSPSGIKYSQELAYSLSKREEIVIICGRYEGIDQRIIDLYVDFEISIGDYVLSSGEIAALVLIDSVYRLLD 154 Borrelia burgdo...
P47683        80 --H---VVLLSPEGEQFSQNCAKKLTKYEHLILLSGHYEGFDQRIYK-YIDQIVSLGDFVLSGGELVALSVIDATVRLIK 153 Mycoplasma geni...
O25766        80 --T---IFLSAVGKPFKQTDAMR-LAQKKHVVLVCGRYEGFDERSIELGADEVFCIGDFILTGGELGALCLIDSIARHIQ 153 Helicobacter py...
WP_017532956  80 --K---VVLLSPEGQQFSQPMAQALTQTEHLILICGHYEGFDYRLYK-HVDQIISLGDFVLSGGELVALSVIDATVRLIK 153 Mycoplasma pneu...
P07020        81 gaK---VIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIP 157 Escherichia coli
P43912        81 gaK---VIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIP 157 Haemophilus inf...
O31741        81 apR---IILVCPQGERFTQKKAEQLAKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLP 157 Bacillus subtil...
P72828        81 --E---VILMTPQGQPMDQALFRELTNYDQLVLICGHYEGVDERVCQ-LVTREVSLGDFVLTCGEIPALTLINGVIRLLP 154 Synechocystis s...
O51641        80 --T---TIFLSPSGIKYSQELAYSLSKREEIVIICGRYEGIDQRIIDLYVDFEISIGDYVLSSGEIAALVLIDSVYRLLD 154 Borrelia burgdo...
P47683        80 --H---VVLLSPEGEQFSQNCAKKLTKYEHLILLSGHYEGFDQRIYK-YIDQIVSLGDFVLSGGELVALSVIDATVRLIK 153 Mycoplasma geni...
O25766        80 --T---IFLSAVGKPFKQTDAMR-LAQKKHVVLVCGRYEGFDERSIELGADEVFCIGDFILTGGELGALCLIDSIARHIQ 153 Helicobacter py...
WP_017532956  80 --K---VVLLSPEGQQFSQPMAQALTQTEHLILICGHYEGFDYRLYK-HVDQIISLGDFVLSGGELVALSVIDATVRLIK 153 Mycoplasma pneu...
P07020        81 gaK---VIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIP 157 Escherichia coli

1P9P_A       164 GVLGHEASATEDSF--AEGLLDCPHYTRPE----VLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENl-ALT 236
P43912       158 GVLGKQASAEEDSF--ADGLLDCPHYTRPE----VLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGl-ALT 230 Haemophilus inf...
O31741       158 GVLGKEASHIEDSF--STGLLEHPHYTRPA----DYKGLKVPETLLSGNHAKIEEWRNKESIRRTYLRRPDLLKDh-PLT 230 Bacillus subtil...
P72828       155 GTVGKEASLIAESF--STDLLDYPHYTRPP----VFRGLAVPPVLLSGNHQAIAQWRLEQQEERTQQRRPDLWQKwqDRQ 228 Synechocystis s...
O51641       155 GVINPN-SLLEESFgvKNGLLEYPHYTRPY----DFKGIKVPEVLLSGHHANIKNWRLVKAREKTKKNRYDLYLKylEII 229 Borrelia burgdo...
P47683       154 GVINDQ-SLICESF--NDNLLDFPVYTRPY----DLKGDKVPEVLLSGDHQKIESFRKEQQILKTAKYRPDLYKKylENK 226 Mycoplasma geni...
O25766       154 GVLGNAQSLENESF--ENHYLEAPNFANAVfkskEINKIPAPLEYSKGNHAKIKQLKLDLSKLRTKFYRLDLFKQhkS-- 229 Helicobacter py...
WP_017532956 154 GVINDQ-SLIHESF--NNYLLDFPAYTRPY----DLDGDKVPEILLSGDHKKIEAYRKEQQLLRTAQYRPDLYKQylAKK 226 Mycoplasma pneu...
P07020       158 GVLGHEASATEDSF--AEGLLDCPHYTRPE----VLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENl-ALT 230 Escherichia coli
P43912       158 GVLGKQASAEEDSF--ADGLLDCPHYTRPE----VLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGl-ALT 230 Haemophilus inf...
O31741       158 GVLGKEASHIEDSF--STGLLEHPHYTRPA----DYKGLKVPETLLSGNHAKIEEWRNKESIRRTYLRRPDLLKDh-PLT 230 Bacillus subtil...
P72828       155 GTVGKEASLIAESF--STDLLDYPHYTRPP----VFRGLAVPPVLLSGNHQAIAQWRLEQQEERTQQRRPDLWQKwqDRQ 228 Synechocystis s...
O51641       155 GVINPN-SLLEESFgvKNGLLEYPHYTRPY----DFKGIKVPEVLLSGHHANIKNWRLVKAREKTKKNRYDLYLKylEII 229 Borrelia burgdo...
P47683       154 GVINDQ-SLICESF--NDNLLDFPVYTRPY----DLKGDKVPEVLLSGDHQKIESFRKEQQILKTAKYRPDLYKKylENK 226 Mycoplasma geni...
O25766       154 GVLGNAQSLENESF--ENHYLEAPNFANAVfkskEINKIPAPLEYSKGNHAKIKQLKLDLSKLRTKFYRLDLFKQhkS-- 229 Helicobacter py...
WP_017532956 154 GVINDQ-SLIHESF--NNYLLDFPAYTRPY----DLDGDKVPEILLSGDHKKIEAYRKEQQLLRTAQYRPDLYKQylAKK 226 Mycoplasma pneu...
P07020       158 GVLGHEASATEDSF--AEGLLDCPHYTRPE----VLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENl-ALT 230 Escherichia coli

1P9P_A       237 EEQAR 241
P43912       231 DEQRK 235 Haemophilus influenzae Rd KW20
O31741       231 EQQRK 235 Bacillus subtilis subsp. subtilis str. 168
P72828       229 PSP-- 231 Synechocystis sp. PCC 6803 substr. Kazusa
O51641       230 GEDNG 234 Borrelia burgdorferi B31
P47683       227 NEKNK 231 Mycoplasma genitalium G37
O25766           -----     Helicobacter pylori 26695
WP_017532956 227 DEKNK 231 Mycoplasma pneumoniae
P07020       231 EEQAR 235 Escherichia coli
P43912       231 DEQRK 235 Haemophilus influenzae Rd KW20
O31741       231 EQQRK 235 Bacillus subtilis subsp. subtilis str. 168
P72828       229 PSP-- 231 Synechocystis sp. PCC 6803 substr. Kazusa
O51641       230 GEDNG 234 Borrelia burgdorferi B31
P47683       227 NEKNK 231 Mycoplasma genitalium G37
O25766           -----     Helicobacter pylori 26695
WP_017532956 227 DEKNK 231 Mycoplasma pneumoniae
P07020       231 EEQAR 235 Escherichia coli
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