1BDX


Conserved Protein Domain Family
ruvA
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TIGR00084: ruvA 
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Holliday junction DNA helicase, RuvA subunit
RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]
Links
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Statistics
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PSSM-Id: 129193
Aligned: 9 rows
Threshold Bit Score: -1
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1BDX_A         1 MIGRLRGIIIEKQP-----PLVLIEVGGVGYEVHMPMTCFYELPEaG--QEAIVFTHFVVREDA----QLLYGFNNKQER 69  Escherichia col...
P08576         1 MIGRLRGIIIEKQP-----PLVLIEVGGVGYEVHMPMTCFYELPE-Ag-QEAIVFTHFVVREDA----QLLYGFNNKQER 69  Escherichia coli
O05392         1 MIEFVKGTIDYVSP-----QYIVIENGGIGYQIFTPNPFIYKERS-Q----ETIFTYHHIREDA----FSLYGFSTREEK 66  Bacillus subtil...
P73554         1 MIQFLQGQVVTVTKniqnrWFLILSVNGVGYELQVPHSLAQQWTP-PppEPQQVFTHLLVRQDQ----IALFGFGRLAER 75  Synechocystis s...
O25549         1 MIVGLIGVVEKISA-----LEVHIEVQGVVYGVQVSMRTAALLEA-G--QKARLKILQVIKEDA----HLLYGFLEEGEK 68  Helicobacter py...
P70827         1 MINKIHGKVIEKKE-----SSLVLMTTVFEFELLVSAFCLANFNL-S--DKVELFTYLYTRENE----LKLFGFLNSDER 68  Borrelia burgdo...
P75243         1 MIASIFGKITFVGK-----RKIIVEANCISYWFNVKENHSFEKNL-E--KPRQVFCQIIKRMVTnqilEEGFAFNTLEEK 72  Mycoplasma pneu...
WP_010869447   1 MITSIFGKVTFVGK-----RKIIVEHNWISYWFNTKENHKFEKNL-E--KNKQIFCHIIKKIVAnqiiEEAFAFNTLEEK 72  Mycoplasma geni...
P44632         1 MIGRLQGILLEKQP-----PEILLNVQGVGYELLLPMTSFYDLPE-Ig-QETTLFTHLVVREDA----HLLFGFAQKTDR 69  Haemophilus inf...
P08576         1 MIGRLRGIIIEKQP-----PLVLIEVGGVGYEVHMPMTCFYELPE-Ag-QEAIVFTHFVVREDA----QLLYGFNNKQER 69  Escherichia coli
O05392         1 MIEFVKGTIDYVSP-----QYIVIENGGIGYQIFTPNPFIYKERS-Q----ETIFTYHHIREDA----FSLYGFSTREEK 66  Bacillus subtil...
P73554         1 MIQFLQGQVVTVTKniqnrWFLILSVNGVGYELQVPHSLAQQWTP-PppEPQQVFTHLLVRQDQ----IALFGFGRLAER 75  Synechocystis s...
O25549         1 MIVGLIGVVEKISA-----LEVHIEVQGVVYGVQVSMRTAALLEA-G--QKARLKILQVIKEDA----HLLYGFLEEGEK 68  Helicobacter py...
P70827         1 MINKIHGKVIEKKE-----SSLVLMTTVFEFELLVSAFCLANFNL-S--DKVELFTYLYTRENE----LKLFGFLNSDER 68  Borrelia burgdo...
P75243         1 MIASIFGKITFVGK-----RKIIVEANCISYWFNVKENHSFEKNL-E--KPRQVFCQIIKRMVTnqilEEGFAFNTLEEK 72  Mycoplasma pneu...
WP_010869447   1 MITSIFGKVTFVGK-----RKIIVEHNWISYWFNTKENHKFEKNL-E--KNKQIFCHIIKKIVAnqiiEEAFAFNTLEEK 72  Mycoplasma geni...
P44632         1 MIGRLQGILLEKQP-----PEILLNVQGVGYELLLPMTSFYDLPE-Ig-QETTLFTHLVVREDA----HLLFGFAQKTDR 69  Haemophilus inf...

1BDX_A        70 TLFKELIKTNGVGPKLALAILSGMSAQQFVNAVEREEVGALVKLPGIGKKTAERLI-VEMKDRFKGLHG-DLFT------ 141 Escherichia col...
P08576        70 TLFKELIKTNGVGPKLALAILSGMSAQQFVNAVEREEVGALVKLPGIGKKTAERLI-VEMKDRFKGLHG-DLFTpaadlv 147 Escherichia coli
O05392        67 ALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENEDEAFLVKFPGVGKKTARQII-LDLKGKLADVVP-EMIEnlfnhe 144 Bacillus subtil...
P73554        76 DLFGQLMGVTGIGAQLAIALIETLGLEGLVQAVVTGNVKQLCQTPGVGKKGAERLA-LELKTKLSQWHKlQMGTgetd-- 152 Synechocystis s...
O25549        69 ILFERLLKINGVGGRIALAILSSFSPNEFESIIATKEVKRLQQVPGIGKKLADKIM-VDLIGFFIQDEN----------- 136 Helicobacter py...
P70827        69 EIFKELIGVSGVGPRAALRVLSNIRYNEFKEAIDKEDIELVSKIKGIGKKMAGKMF-LHLQGKLLINSElESTG------ 141 Borrelia burgdo...
P75243        73 EWFSKFIELNGIGSKTALNLLNNNLEEMRDYIKN-SNYHALTKLTGSNSKVARALLaLELYDRDDGGKRiKPNT------ 145 Mycoplasma pneu...
WP_010869447  73 EWFCRLIELNGIGSKTALNLLNNDLEEIKQYILE-NNYSALCGINGVNNKIARALLsLEIFEKSENNKNiKG-------- 143 Mycoplasma geni...
P44632        70 TLFRELIKTNGVGPKLALAILSAMSVEQFAYAIEREELSKLTKIPGVGKKTAERLL-VELKGKFKGVKQsDFFVesthip 148 Haemophilus inf...
P08576        70 TLFKELIKTNGVGPKLALAILSGMSAQQFVNAVEREEVGALVKLPGIGKKTAERLI-VEMKDRFKGLHG-DLFTpaadlv 147 Escherichia coli
O05392        67 ALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENEDEAFLVKFPGVGKKTARQII-LDLKGKLADVVP-EMIEnlfnhe 144 Bacillus subtil...
P73554        76 DLFGQLMGVTGIGAQLAIALIETLGLEGLVQAVVTGNVKQLCQTPGVGKKGAERLA-LELKTKLSQWHKlQMGTgetd-- 152 Synechocystis s...
O25549        69 ILFERLLKINGVGGRIALAILSSFSPNEFESIIATKEVKRLQQVPGIGKKLADKIM-VDLIGFFIQDEN----------- 136 Helicobacter py...
P70827        69 EIFKELIGVSGVGPRAALRVLSNIRYNEFKEAIDKEDIELVSKIKGIGKKMAGKMF-LHLQGKLLINSElESTG------ 141 Borrelia burgdo...
P75243        73 EWFSKFIELNGIGSKTALNLLNNNLEEMRDYIKN-SNYHALTKLTGSNSKVARALLaLELYDRDDGGKRiKPNT------ 145 Mycoplasma pneu...
WP_010869447  73 EWFCRLIELNGIGSKTALNLLNNDLEEIKQYILE-NNYSALCGINGVNNKIARALLsLEIFEKSENNKNiKG-------- 143 Mycoplasma geni...
P44632        70 TLFRELIKTNGVGPKLALAILSAMSVEQFAYAIEREELSKLTKIPGVGKKTAERLL-VELKGKFKGVKQsDFFVesthip 148 Haemophilus inf...

1BDX_A       142 -------PaadlvltspaspaTDDAE-QEAVAALVALGYKPQEASRMVSKIAR-PdASSETLIREALRAAL 203 Escherichia coli BW2952
P08576       148 ltspaspA-------------TDDAE-QEAVAALVALGYKPQEASRMVSKIARpD-ASSETLIREALRAAL 203 Escherichia coli
O05392       145 -erlekqT-------------AETAL-EEALEALRVLGYAEKEIKKVLPHLKEeIgLTTDQYVKKALQKLL 200 Bacillus subtilis subsp....
P73554       153 ----stlP-------------TTALL-EDLEMTLLALGYTQTEIQQAIAMVSQvPdVAQSEDPEVWIRQAI 205 Synechocystis sp. PCC 68...
O25549       137 ----------------------RPAR-NEVFLALESLGFKSAEINQVLKTLKP-N-LSIEAAIKEALQQLR 182 Helicobacter pylori 26695
P70827       142 -----------------------LFRfKELEESIVSMGFDRKIVNSKIREAFNlAeFANLKDSEK--EQFL 187 Borrelia burgdorferi B31
P75243       146 ---------------------AMANDyDEMFDTLKSLGYKPQDIQNALSKIEIkPnFDVSEVIAEVIK-LM 194 Mycoplasma pneumoniae M129
WP_010869447 144 -------V-------------QVADGyDELFETLKSLGYKQQEIQDALKMIEVkPdFDISQLVAEVIK-LM 193 Mycoplasma genitalium
P44632       149 lspsiesH-------------SESSS-DEAISALIALGYKPVEAEKMVKRVAKpE-LTSEQVIREALKVAL 204 Haemophilus influenzae R...
P08576       148 ltspaspA-------------TDDAE-QEAVAALVALGYKPQEASRMVSKIARpD-ASSETLIREALRAAL 203 Escherichia coli
O05392       145 -erlekqT-------------AETAL-EEALEALRVLGYAEKEIKKVLPHLKEeIgLTTDQYVKKALQKLL 200 Bacillus subtilis subsp....
P73554       153 ----stlP-------------TTALL-EDLEMTLLALGYTQTEIQQAIAMVSQvPdVAQSEDPEVWIRQAI 205 Synechocystis sp. PCC 68...
O25549       137 ----------------------RPAR-NEVFLALESLGFKSAEINQVLKTLKP-N-LSIEAAIKEALQQLR 182 Helicobacter pylori 26695
P70827       142 -----------------------LFRfKELEESIVSMGFDRKIVNSKIREAFNlAeFANLKDSEK--EQFL 187 Borrelia burgdorferi B31
P75243       146 ---------------------AMANDyDEMFDTLKSLGYKPQDIQNALSKIEIkPnFDVSEVIAEVIK-LM 194 Mycoplasma pneumoniae M129
WP_010869447 144 -------V-------------QVADGyDELFETLKSLGYKQQEIQDALKMIEVkPdFDISQLVAEVIK-LM 193 Mycoplasma genitalium
P44632       149 lspsiesH-------------SESSS-DEAISALIALGYKPVEAEKMVKRVAKpE-LTSEQVIREALKVAL 204 Haemophilus influenzae R...
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