3RF9


Conserved Protein Domain Family
rRNA_mod_RlmN
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TIGR00048: rRNA_mod_RlmN 
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23S rRNA (adenine(2503)-C(2))-methyltransferase
Members of this family are RlmN, a 23S rRNA m2A2503 methyltransferase in the radical SAM enzyme family. Closely related is Cfr, a Staphylococcus sciuri plasmid-borne homolog to this family, Cfr, has been identified as essential to transferrable resistance to chloramphenicol and florfenicol. Cfr methylates 23S RNA at a different site. [Protein synthesis, tRNA and rRNA base modification]
Links
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Statistics
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PSSM-Id: 272874
Aligned: 6 rows
Threshold Bit Score: 557.508
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3RF9_A  12 TtKdgKINLLDLNRQQMREFFKDLGEKPFRADQVMKWMYHYCCDNFDEMTD-INKVLRGKLKEVAEIRAPEVVEEQRSSD 90  Escherichia coli K-12
O34617  13 L-RteRPSIYSFELDEIKQWLTDNGEKPFRAAQIFEWLYEKRVSSFEDMTN-LSKDLREKLNTRFVLTTLKTAVKQTSQD 90  Bacillus subtilis sub...
Q55880   1 MaPspAP-LLSLSLPELTDWVQTTGQPAYRGKQIHQWLYQKGARSLTAMTD-LPKVWREK-NVHYPIGRSVIDHCAVAPD 77  Synechocystis sp. PCC...
P36979  12 TtKdgKINLLDLNRQQMREFFKDLGEKPFRADQVMKWMYHYCCDNFDEMTD-INKVLRGKLKEVAEIRAPEVVEEQRSSD 90  Escherichia coli K-12
O25970   1 ----mKASIYDFTLKELSQLLK----PSFRAKQLYLWLYAKYKTSFKDMQNnFSKDFIAYLEREFALRTIEITHVRESVD 72  Helicobacter pylori 2...
P44665  19 PaK--KINLMDLTRQQMREFFKELGEKPFRADQLVKWIYHFGEDNFDNMTN-INKKLREKLKAVAEIKAPEVAVEQRSAD 95  Haemophilus influenza...

3RF9_A  91 GTIKWAIAVGD--QRVETVYIPEDDR--------------ATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWR 154 Escherichia coli K-12
O34617  91 GTMKFLFELHDg-YTIETVLMRHEYG--------------NSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVK 155 Bacillus subtilis sub...
Q55880  78 HTRKYLLRLADg-LIIETVGIPSSKR--------------LTVCVSSQVGCAMDCNFCATGKGGFIRNLESHEIVDQVLT 142 Synechocystis sp. PCC...
P36979  91 GTIKWAIAVGD--QRVETVYIPEDDR--------------ATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWR 154 Escherichia coli K-12
O25970  73 GSKKYLFKSLRdnHTFEAVLLKMKDKkidaetnailerekYTVCVSCQIGCQVGCSFCFTQKGGFVRNLKASEIIQQALL 152 Helicobacter pylori 2...
P44665  96 GTIKWAMQVGE--QQVETVYIPEADR--------------ATLCVSSQVGCALACTFCSTAQQGFNRNLTVSEIIGQVWR 159 Haemophilus influenza...

3RF9_A 155 AAKIV---GaakVTGQRpITNVVMMGMGEPLLNLNNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGD-MIDVAL 230 Escherichia coli K-12
O34617 156 VQKAL---D---ETDER-VSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYEFADqQMQINF 228 Bacillus subtilis sub...
Q55880 143 VQ------E---EFHER-VSNVVFMGMGEPLLNLPQVVKAVECLNQVVG--IGQRALTISTVGLPGKIRQLADrHLQVTF 210 Synechocystis sp. PCC...
P36979 155 AAKIVgaaK---VTGQRpITNVVMMGMGEPLLNLNNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGD-MIDVAL 230 Escherichia coli K-12
O25970 153 IKEDN---N---LPLEK-ALNIVFMGMGEPLNNLDEVCKAIEIFNTGMQ--ISPKRITISTSGVADKIPILAGkNLGVQL 223 Helicobacter pylori 2...
P44665 160 ASKIIgnfG---VTGVRpITNVVMMGMGEPLLNVANVVPAMEIMLDDFAYGLSKRRVTLSTSGVVPALDNLSK-MIDVAL 235 Haemophilus influenza...

3RF9_A 231 AISLHAPNDEIRDEIVPINKKYNIETFLAAVRRYLEKSNAnqgRVTIEYVMLDHVNDGTEHAHQLAELLKDTPCKINLIP 310 Escherichia coli K-12
O34617 229 AISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGR---RISFEYGLFGGVNDQVEHAEELADLLEGVKCHVNLIP 305 Bacillus subtilis sub...
Q55880 211 AVSLHAPNQTLRQSLIPSARHYPLEQLLADCRAYVETTGR---RVTFEYVLLAGVNDQPVHAEELAQKLRGFQTHVNLIP 287 Synechocystis sp. PCC...
P36979 231 AISLHAPNDEIRDEIVPINKKYNIETFLAAVRRYLEKSNAnqgRVTIEYVMLDHVNDGTEHAHQLAELLKDTPCKINLIP 310 Escherichia coli K-12
O25970 224 AISLHAVDDKTRSSLMPLNKKYNIECVLNEVRKWPLEQRK---RVMFEYLLIKDLNDSLDCAKKLLKLLNGIKSKVNLIL 300 Helicobacter pylori 2...
P44665 236 AISLHAPNDELRDEIVPINKKYNIKTLIDSVNRYLNVSNAnhgKVTIEYVMLDHVNDGVEHAHQLAEVLKNTPCKINLIP 315 Haemophilus influenza...

3RF9_A 311 WNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQL-AGDVIDRTK 367 Escherichia coli K-12
O34617 306 VNYVPERDYVRTPRDQIFAFEKTLKSRGVNVTIRREQGHDIDAACGQLrAKERQDETR 363 Bacillus subtilis subsp. subtilis str. 168
Q55880 288 YNPISEVDYQRPTEAQINQFAQVLSDHRIAVSVRYSRGVQADAACGQLrASRKEELAE 345 Synechocystis sp. PCC 6803 substr. Kazusa
P36979 311 WNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQL-AGDVIDRTK 367 Escherichia coli K-12
O25970 301 FNPHEGSKFERPSLENARMFADFLNSKGLLCTIRESKALDIEAACGQLrEKKLSQQI- 357 Helicobacter pylori 26695
P44665 316 WNPFPEAPYAKSSNTRIDRFQKTLMEYDFTVIIRKTRGDDIDAACGQL-AGDVIDRTK 372 Haemophilus influenzae Rd KW20
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