4TMK,2TMK


Conserved Protein Domain Family
DTMP_kinase

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TIGR00041: DTMP_kinase 
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dTMP kinase
Function: phosphorylation of DTMP to form DTDP in both de novo and salvage pathways of DTTP synthesis. Catalytic activity: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]
Statistics
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PSSM-Id: 161676
View PSSM: TIGR00041
Aligned: 14 rows
Threshold Bit Score: 192.193
Threshold Setting Gi: 6016459
Created: 7-Oct-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4TMK_A   1 MR-SKYIVIEGLEGAGKTTARNVVVETLEQ--LGiRDMVFTREPGGTQLAEKLRSL----LLdikSVGDEVITDKAEVLM 73  Escherichia coli
P75106   1 MKqGVFVAIEGVDGAGKTVLLEAFKQRFPQsfLG-FKTLFSREPGGTPLAEKIRAL----LL---HEAMEPLT---EAYL 69  Mycoplasma pneumoniae...
P47252   1 MNkGVFVVIEGVDGAGKTALIEGFKKLYPTkfLN-YQLTYTREPGGTLLAEKIRQL----LL---NETMEPLT---EAYL 69  Mycoplasma genitalium...
P37537   1 Ms-GLFITFEGPEGAGKTTVLQEIKNILTA--EG-LQVMATREPGGIDIAEQIREV----IL---NENNILMDPKTEALL 69  Bacillus subtilis sub...
O30175   1 ----MLIAVEGIDGAGKTTIAAYIAELLKE--KG-YKVKVLKEPGDSKFGKKIKSS---------EERLSPEE---ELEL 61  Archaeoglobus fulgidu...
Q57741   1 MVdNMFIVFEGIDGSGKTTQSKLLAKKMDA--------FWTYEPSNSLVGKIIREI---------LSGKTEVDNKTLALL 63  Methanocaldococcus ja...
O27793   1 ----MYICFEGIDGSGKTTHAALTASWLRE--NG-YMVHEVREPTDSNIGSLIRSMl---sS---PDARTPDVQRMLALL 67  Methanothermobacter t...
P00572   2 MGrGKLILIEGLDRTGKTTQCNILYKKLQP--N---CKLLKFPERSTRIGGLINEY-----L---TDDSFQLSDQAIHLL 68  Saccharomyces cerevis...
Q55593   1 MA-ALFIVLEGIDGSGKTTQGDLLLAHFQR--QG-LAAVLSPEPTNGPVGRLIRQAlqgdLF---TYNDARQFEAQMGYL 73  Synechocystis sp. PCC...
2TMK_A   3 gR-GKLILIEGLDRTGKTTQCNILYKKLQP--N---CKLLKFPERSTRIGGLINEY-----L---TDDSFQLSDQAIHLL 68  baker's yeast
4TMK_A  74 FYAARV---QLVETVIKPALANGTWVIGDRHDLSTQAYQGGGrGIDQHMLATLRDAVLGdfrPDLTLYLDVTPEVGLKRA 150 Escherichia coli
P75106  70 FAASRT---EHVRQLIQPALQQKQLVIVDRFVWSSYAYQGLIkKVGLDVVKKLNADAVGdsmPDFTFIVDCDFETALNRM 146 Mycoplasma pneumoniae...
P47252  70 FAAART---EHISKLIKPAIEKEQLVISDRFVFSSFAYQGLSkKIGIDTVKQINHHALRnmmPNFTFILDCNFKEALQRM 146 Mycoplasma genitalium...
P37537  70 YAAARR---QHLVEKVKPALEQGFIVLCDRFIDSSLAYQGYArGLGIDEVLSINEFAIGdmmPHVTVYFSIDPEEGLKRI 146 Bacillus subtilis sub...
O30175  62 FLKDRE---IDARENILPALQSGYAVVMDRYYFSNIAYQS-ArGIDARLIREMNEKIAPk--PDLTILLDVEPEIALERV 135 Archaeoglobus fulgidu...
Q57741  64 FAADRI---EHTKLIKEELKKRD--VVCDRYLYSSIAYQS-VaGVDENFIKSINRYALK---PDIVFLLIVDIETALKRV 134 Methanocaldococcus ja...
O27793  68 FAADR----LTLRSKIEGDWAED-VVVSDRCYYSSMVYQG-----PEEWVCEINRFAPR---PDVVILLDIDVEVAMERC 134 Methanothermobacter t...
P00572  69 FSANR----WEIVDKIKKDLLEGKNIVMDRYVYSGVAYSAAKgTNGMDLDWCLQPDVGLl-kPDLTLFLSTQDVDNNAEK 143 Saccharomyces cerevis...
Q55593  74 FAADRHyhlYHPGDGVEAKLAQQCHVITTRYYFSSLAYNCHT-EADWEFVQRLNQSFPQ---PDWVIYLDLPVDLALQRL 149 Synechocystis sp. PCC...
2TMK_A  69 FSANR----WEIVDKIKKDLLEGKNIVMDRYVYSGVAYSAAKgTNGMDLDWCLQPDVGLl-kPDLTLFLSTQDVDNNAEK 143 baker's yeast
4TMK_A 151 RARGE---LD----RIEQESFDFFNRTRARYLELAAQ-D-----KSIHTIDATQP-LEAVMDAI 200 Escherichia coli
P75106 147 AKRGQdnlLD----NTVKKQAD-FNTMRQYYHSLVD--N-----KRVFLLDGQNQ-TGCLEQFI 197 Mycoplasma pneumoniae M129
P47252 147 QKRGNdnlLD----EFIKGKND-FDTVRSYYLSLVD--K-----KNCFLINGDNK-QEHLEKFI 197 Mycoplasma genitalium G37
P37537 147 YANGSr-eKN----RLDLEKLDFHTKVQEGYQELMKRfP-----ERFHSVDAGQS-KDLVVQDV 199 Bacillus subtilis subsp. subtilis str...
O30175 136 RKRGK---------LSPFEKLDYLRKVRKCFLENAD--------ETTVVVDASKP-LEEVKEEV 181 Archaeoglobus fulgidus DSM 4304
Q57741 135 KTKDI------------FEKKDFLKKVQDKYLELAE--E-----YNFIVIDTTKKsVEEVHNEI 179 Methanocaldococcus jannaschii DSM 2661
O27793 135 GGTDE------------FEDPLYLAGVRERYLELAD--K-----NGFYTVNAERG-VNLIQRDI 178 Methanothermobacter thermautotrophicu...
P00572 144 SGFGD----------ERYETVKFQEKVKQTFMKLLDKeIrk-gdESITIVDVTNKgIQEVEALI 196 Saccharomyces cerevisiae S288c
Q55593 150 GDRQQ---LEdqapRECYEQREKLISVHRNYDRIFAHyQ-----GQLCRLDASLP-VEQLHQAI 204 Synechocystis sp. PCC 6803 substr. Ka...
2TMK_A 144 SGFGD----------ERYETVKFQEKVKQTFMKLLDK-EirkgdESITIVDVTNKgIQEVEALI 196 baker's yeast
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