Conserved Protein Domain Family
Mtu_PIN_fam
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TIGR00028: Mtu_PIN_fam 
toxin-antitoxin system PIN domain toxin
Members of this protein consist almost entirely of a PIN (PilT N terminus) domain (see pfam01850). This family was originally defined a set of twelve closely related paralogs found in Mycobacterium tuberculosis, but additional members are found now Synechococcus sp. WH8102, etc. Inspection of genomic regions suggests these represent toxin components of toxin-antitoxin regions, potentially important to creating dormant persister cells.
Links
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Statistics
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PSSM-Id: 272863
Aligned: 11 rows
Threshold Bit Score: 124.802
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q10800         1 MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPdSVLAGFIRVVTNRRVFTE----PTSPQDAWQAVDALLAA 76  Mycobacterium t...
WP_003403837   1 MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPnLVWASFLRLATNRRIFEI----PSPRAEAFAFVEAVTAQ 76  Mycobacterium t...
WP_003899644   2 SETFDVDVLVHATHRASPFHDKAKTLVERFLAGPGLVYLLwPVALGYLRVVTHPTLLGA----PLAPEVAVENIEQFTSR 77  Mycobacterium t...
WP_003406304   1 MIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTyPALFGFLRIATSARVLAA----PLPTADAIAYVREWLSQ 76  Mycobacterium t...
WP_010924491   2 MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAwVPLLAFVRLATKVGLFPR----PLPREAAITQVADWLAA 77  Mycobacterium t...
WP_015345137  18 MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCR-ATQQSLLRLLTNRTVLGAygspPLTNREAWAAYAAFLDD 96  Mycobacterium t...
WP_003900837   1 MLSIDTNILLYAQNRDCPEHDAAAAFLVECAGRADVAVCE-LVLMELYQLLRNPTVVTR----PLEGPEAAEVCQTFRRN 75  Mycobacterium t...
WP_003417282   2 RALLDVNVLLALLDRDHVDHERARAWITGQIERG-WASCA-ITQNGFVRVISQPR-YPS----PISVAHAIDLLARATHT 74  Mycobacterium t...
WP_003900860   1 MALLDVNALVALAWDSHIHHARIREWFTANATLG-WATCP-LTEAGFVRVSTNPKVLPS----AIGIADARPVLVALRAV 74  Mycobacterium t...
WP_003403218   2 TVLLDANVLIALVVAEHVHHDAAADWLM--ASDTGFATCP-MTQGSLVRFLVRSG---------QSAAAARDVVSAVQCT 69  Mycobacterium t...
WP_003412970   2 TALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNG-WATTP-ITEAGYVRISSNRSVMQV----STTPAIAIAQLAAMTSL 75  Mycobacterium t...

Q10800        77 PAAMRLRPGE-RHWMAFRQLASDVDANGNDIADAHLAAYALENN-ATWLSADR--G---FARFRRLRWRHPL 141 Mycobacterium tuberculosis
WP_003403837  77 PHHLPTNPGP-RHLMLLRKLCDEADASGDLIPDAVLAAIAVGHH-CAVVSLDR--D---FARFASVRHIRPP 141 Mycobacterium tuberculo...
WP_003899644  78 PHVRQVGEAN-GFWPVYRRVADPVKPRGNLVPDAHLVALMRHHGiATIWSHDR--D---FRKFEGIRIRDPF 143 Mycobacterium tuberculo...
WP_003406304  77 PNVDLLTAGP-RHLDIALGLLDKLGTASHLTTDVQLAAYGIEYD-AEIHSSDT--D---FARFADLKWTDPL 141 Mycobacterium tuberculo...
WP_010924491  78 PSAVLVNPTV-RHADILARMLTYVGTGANLVNDAHLAALAVEHR-ASIVSYDS--D---FGRFEGVRWDQPP 142 Mycobacterium tuberculosis
WP_015345137  97 DRIVLAGAEPdGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGG-FELVTTDT--A---FTQYGGIELRLLA 162 Mycobacterium tuberculosis
WP_003900837  76 RRWALLENAP-VMNEVWVLAATPRIAR-RRLFDARLALTLRHHGvDEFATRNIn-G---FTDFGFSRVWDPI 141 Mycobacterium tuberculo...
WP_003417282  75 RYHE-FWSCT-VSILDSKVIDRSRLHSPKQVTDAYLLALAVAHD-GRFVTFDQsiA---LTAVPGATKQHLA 140 Mycobacterium tuberculo...
WP_003900860  75 GGHRFL-----ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRG-VRLVTFDA--GvftLAQQRPKTPVELL 138 Mycobacterium tuberculo...
WP_003403218  70 SRHE-FWPDA-LSFA---GVEVAGVVGHRQVTDAYLAQLARSHD-GQLATLDS--G---LAHLHGDVAVLIP 130 Mycobacterium tuberculo...
WP_003412970  76 AGHT-FWPDD-VPLIVGSAGDRDAVSNHRRVTDCHLIALAARYG-GRLVTFDA--A---LADSASAGLVEVL 139 Mycobacterium tuberculo...
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