Conserved Protein Domain Family
PRK14868

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PRK14868: PRK14868 
DNA topoisomerase VI subunit B; Provisional
Statistics
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PSSM-Id: 237842
Aligned: 11 rows
Threshold Bit Score: 1370.26
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
289580320   1 MTSFQSTLGEESG---IAEELAESQQAISIAEFFEKNKHMLGFDSGARGLVTAVKEAVDNALDAAEEAGILPDIYVEIQE 77 
169235746   1 MTSFQSTLDDDEDg--IAEELAASQREISVAEFFEKNKHMLGFDSGARGLVTAVKEAVDNALDATEEAGILPDIYVEISE 78 
55377343    1 MTSYQSQLGEGEG---IAEELAESQRAISIAEFFEKNKHMLGFDSEARALVTAVKEAVDNALDACEEAGILPDIYVEIQE 77 
15790023    1 MTSFQSTLDDDEDg--IAEELAASQREISVAEFFEKNKHMLGFDSGARGLVTAVKEAVDNALDATEEAGILPDIYVEISE 78 
76802379    1 MTSYQSQLGDGGGgepIAEELAESQQSISIAEFFEKNKQMLGFDSDAKALVTAVKEAVDNALDAAEEAGILPDIYVEIED 80 
257388768   1 MTSYQSRLGEGEG---IADELAESQRSISIAEFFEKNRQMLGFDSGAKALVTAVKEAVDNALDACEEAGITPDIYVEIQE 77 
257051218   1 ---MQSTLGE-EG---IAEELAESQRQISIAEFFEKNKHMLGFDSGARALVTAVKEGVDNSLDACEEADIFPDVYVEIED 73 
222479739   1 MTSFQSTIGDEEG---IAEELAEGQREISIAEFFEKNKHMLGFDSGARGLVTAVKEAVDNALDATEEAGVLPDIYIEIEE 77 
284165558   1 MTSFQSTLGDEAG---IAEELAENQQAISIAEFFEKNKHMLGFDSGARGLVTAVKEAVDNALDAAEESGILPDIYVEIEE 77 
292655721   1 MTSFQSTLGDEPG---IAEELAKGQREISIAEFFEKNKHMLGFDSGARGLVTAVKEAVDNALDATEEAGIQPDIYVEIAE 77 
300711733   1 MTSLQSTLGEETG---IADELAANQREISIAEFFEKNKHMLGFDSGARGLVTAVKEAVDNALDATEEAGILPDIYVEIEE 77 
289580320  78 EGDYYRLIVEDNGPGLTKESLPKVFGKLLYGSRFHAREQSRGQQGIGISAAVLYSQLTSGKPAKITSRTEGTDEAQYFEL 157
169235746  79 GRDYYTLIVEDNGPGITNAQIPKIFGKLLYGSRFHAREQSRGQQGIGISAAVLYSQLTSGKPVRIESRTQDSETANVYEL 158
55377343   78 SGDYYKLVVEDNGPGITKEQAPKIFGKLLYGSRFHAREQNRGQQGIGISAAVLYSQLTSGKPAKITSRPKGQDEAQYFEL 157
15790023   79 GRDYYTLIVEDNGPGITNAQIPKIFGKLLYGSRFHAREQSRGQQGIGISAAVLYSQLTSGKPVRIESRTQDSETANVYEL 158
76802379   81 RGDYYRLTVEDNGPGITKEQIPKVFGKLLYGSRFHAREQTRGQQGIGISAAVLYSQLTSGKPAKITSKTDSHSSAQYFEL 160
257388768  78 AGDYYRLIVEDNGPGITREQIPNIFGKLLYGSRFHKREQNRGQQGIGISAAVLHSQKTSGKPAKITSRTEQHADAQYFEL 157
257051218  74 VGEYYRLVIEDNGPGITREQLPKVFGKLLYGSRFHKREQNRGQQGIGISAAVLYSQLTSGKPAKITSRTKGSEEAHYFEL 153
222479739  78 VGDYYRLVIEDNGPGITKEQLPKVFGKLLYGSRFHAREQSRGQQGIGISAAVLYSQLTSGQPAKITSRPKGQSRAQYFEL 157
284165558  78 AGDYYRLIVEDNGPGITKESLPKVFGKLLYGSRFHAREQSRGQQGIGISAAVLYSQLTSGKPAKITSRTQGSSEAEYFEL 157
292655721  78 AGDYYRLVIEDNGPGITKEQVPKVFGKLLYGSRFHAREQSRGQQGIGISAAVLYSQLTSGKPAKVTSRTQGSEDAEYFEL 157
300711733  78 VGNYYRLVVEDNGPGITREQIPKVFGKLLYGSRFHAREQSRGQQGIGISAAVLYSQLTSGKPAKITSRTQGADEAQYFEL 157
289580320 158 IVDTDDNEPEISVEETTTWDRP-----HGTRIELEMEANMRARQQLHNYIKHTAVVNPHARLELREP--KAHFKFERAT- 229
169235746 159 IIDTDTNEPEISAETEVSAAKSdlrgtHGTRIEMALDANMRARGQLHDYIKHTAVVNPHARIELQEP--GGELKSERAEe 236
55377343  158 IVDTDTNEPEISVDETTTWERP-----HGTRIELEMEANMRARSTLRDYIQDTAVVNPHARVEFDEPglDESLKFERAEr 232
15790023  159 IIDTDTNEPEISAETEVSAAKSdlrgtHGTRIEMALDANMRARGQLHDYIKHTAVVNPHARIELQEP--GGELKSERAEe 236
76802379  161 TIDTDTNEPEIDHEREATWERP-----HGTRIELEMEGNMRARKQLHDYIKYTAVVNPHARVEFHEP--EDSFKSERAT- 232
257388768 158 IVDTDANEPEISVEDTTTWERP-----HGTRIELEMEANMRARQQLHDYIKHTAVVNPHARIELVEP--KEHLKYERTT- 229
257051218 154 IIDTDTNEPEIDVDETTTWDRP-----HGTRIEVELEANLRARQQLHDYIKHTAVVNPHARIEFHEPnmAEPAKFERVEg 228
222479739 158 IIDTDTNEPEIKADEETTWDRP-----HGTRIELEMEANMRARNQLHDYVKHTAVVNPHARFELREPglDEPLKFERAT- 231
284165558 158 IVDTDSNEPEISVEETTSWDRP-----HGTRIELEMEANMRARQQLHDYIKHTAVVNPHARLELREP--QEHFKFERAT- 229
292655721 158 VINTDQNEPEIRTEKTTSWDRP-----HGTRIELEMEANMRARQQLHDYILHTAVVNPHARIELREPglDEPMKFERAT- 231
300711733 158 IIDTDTNEPEISSAETTSWDRP-----HGTRIELEMEANMRARGQLRDYIKHTAVVNPHARIELHEP--NDSFKAERAT- 229
289580320 230 DQLPEETEEIRPHPHGVELGTVIKMLAATDSQTVSGFLQEEFTRVGKKTAESVIDAFRDRHYGREMRWRPPASHes---- 305
169235746 237 ASLPAETDEILPHPHGVELGTLIKMLAETDSHSVSGFLQSEFTRVGSKTATGIIDAFRDEHFGREMRWRPPADA------ 310
55377343  233 AELPDETEEIRPHPHGVELGTLLKMLEATDSYSVSGFMQEEFTRVGGKTADSVIANFNDRHYGRGMAWQPPKVNed---- 308
15790023  237 ASLPAETDEILPHPHGVELGTLIKMLAETDSHSVSGFLQSEFTRVGSKTATGIIDAFRDEHFGREMRWRPPADA------ 310
76802379  233 EELPPETEEIRPHPHGVELGTLLKMLDATDSYSLSGFLQAEFTRVGNKTADGVIDSFRDRHFGREMAWSPPQPHed---- 308
257388768 230 DQLPDETEEIRPHPHGVELGTLLKMLESTDSYSVSGFMQGEFTRVGQKTSDDVIANFNDRHYGREMSWYGPQSHedsvvp 309
257051218 229 ADLPAETKEIRPHPHGVELGTLLKMLEATDSYSVSGFLQGEFTRVGGKTSDKVLDNFRDRHFGREMAWRPPQVHe----- 303
222479739 232 DELPAETEEIRPHPHGVELGALIKMLEATESYSVSGFLQEEFTRVGKKTADSVIDNFRDVYYGRELAWSPPRAHdd---- 307
284165558 230 DQLPEETEEIRPHPHGVELGTVMKMLTSTDSQTVSGFLQEEFTRVGKKTADSIIDEFRDRHYGREMRWRPPTAHed---- 305
292655721 232 DQLPKQTKEIRPHPHGVELGTLLKMLSATESYSVSGFLQEEFTRVGAKTSDKIHDAFRDRHFGREMTWRTPDASea---- 307
300711733 230 DQLPAETEEIRPHPHGVELGTVIKMLGATDSHTLSGFLQEEFTRVGKKTARKVLDNFRNRHFGREMAWELPEPD------ 303
289580320 306 ------------vDLDAAVTDATANKGADATAAFAGAIEDEVADFDRIAHYELRDVVDSAADDVEDEHGTTFGDTVRENA 373
169235746 311 -------------DLEATVADAVANKDATHTAVFARTVADAVRDADSIAPAELGALVADAAADAQDDTGTSFGETVQANV 377
55377343  309 ------------aDIERAVEDAVANKGAETTATFAAAVSDAIHDRDRVAYHEVESIVDSAAEDAEADGDTTFGATVRENA 376
15790023  311 -------------DLEATVADAVANKDATHTAVFARTVADAVRDADSIAPAELGALVADAAADAQDDTGTSFGETVQANV 377
76802379  309 ------------vDIETAVSDAVANKSAEATAAFARAVADEVTDMAALSHAELSAVVASVADDIEAEHDETFGETVRENA 376
257388768 310 tgqrdgdgeavemDVARAVQQAVSNKGKDATAEFADAVASAVSEAGRVSHGRLEAIVDDHADRIEDDYEKTFGDTVREAA 389
257051218 304 ------------gDVEVAVRAAVANKGKDATKSFAREVADAIDDRERVAHHELRAIVDEAAEAAAEGFGTTFGSTVREKA 371
222479739 308 ------------rDVAAAVAGAVANKGKAATTDFADGIAETVAGNDRLSRSELATIVDNVAETVEDDTGKTFGGTVRENA 375
284165558 306 ------------vDLEAAVSDATSNKGADATAAFAAAIAAGVDETDRIAHHELLEVVDSAADEVEAEHGTTFGDTVQENA 373
292655721 308 ------------dDLVAVVEDAVANKGKEATAAFADELVDIVVGKDRIAHGELVTVVENAAETVGEDTDTSFGETVRENV 375
300711733 304 -------------EVESAVREATTNKAADAIEAFATGVAERVAQRERIAHHELEAFVAEVADEIAAEHG-TFGQTARETA 369
289580320 374 VEAVWLELIDAVPvdddeaadpaaddaiesesrlvADLYDLADDATSTRKDDEVIQAFAVRLAGTFEDEtd---dDPRHR 450
169235746 378 VAAVRDALTSDRV----------------------ADVLGPVDEATTVQKDDATVRGLAERIAAKFESG------GDTDR 429
55377343  377 VDAAWNAVSDNLS----------------------SDLYALVDDVTTKRKDDAAVEGLASRLADKFDDD-------GRHR 427
15790023  378 VAAVRDALTSDRV----------------------ADVLGPVDEATTVQKDDATVRGLAERIAAKFESG------GDTDR 429
76802379  377 VEAAWKSVTDDVS----------------------ADCYALVDGATTTRKDDAAVEGLSRRLAEKFTDQe-----DARNR 429
257388768 390 IEAAWSEITADRT----------------------PDVYELVDEVTTTRKDDAAVQGIAERIADKFDDG--------SNR 439
257051218 372 TAAAWAQLIGNTDegdvr-------------etlaSDLYGLVDAATSKRKDDATIEGLADRIAAKFVDE------DDRHR 432
222479739 376 VDAAWQAISGAGDddgagdsedge-nvdpsesslvADAYALVDDATSTRKDDAAVRAMAEALARRFENLd-----GDAFR 449
284165558 374 VDVVWRALIDAREdgaddaergd--ddapaesrlvADCYDLADEATSTRKDDEVIHAFADRLAAKFDDElegeeeNHRHR 451
292655721 376 VEALWPALTDDRE----------------------GDAYAIVDDVTTTQKDDAGKLSMARSIATQFAETt-----GPADR 428
300711733 370 VGAAWSAIVEDRE----------------------AECYRLVDAATSTRKDEATIEALSQRLAAKFDDD-------GRHR 420
289580320 451 LTHKTLREYVDRAAELTEEYDDVAFGDTARENVVEAIWDVMATVPDDPPLVRELEGDRDATSDLVDGMRATDIMAPPTRC 530
169235746 430 VTRDTLDEYVFRAAENTAEYADATIGETARENVADALWARMATVPDDPPNTSALADDRDAASDLLAAMASVNVMAPPTSC 509
55377343  428 LTRDELRGYIDRAADMTEEQDDATFGETARENVLEALWTAAEGVREEPPKVSDIADDRDTASQLLSAMRETDIIAPPTDC 507
15790023  430 VTRDTLDEYVFRAAENTAEYADATIGETARENVADALWARMATVPDDPPNTSALADDRDAASDLLAAMASVNVMAPPTSC 509
76802379  430 FRRSTLREFVDRAADATEEYDDATFGETARENVVEAVWERAVTVPDEPPTVTEVADNRDAAARLLEAMRSTDILSPPTDC 509
257388768 440 VTYAALEDYVDRAAEMTEDMDDATFGETAREKIVDALWEVAARVSDDPPNVSEIADDRDTTSDLLEAMREADIIAPPTDC 519
257051218 433 CTRDQLAEYVERAAENTEEYDDATIGETARENVTTEIWAIMETVPDDVPNVTEIADNRDVAADLLEAMRETDIISPPTDC 512
222479739 450 ITRDDLERLVADAASFVTEQHDVTFGETARENVVETFWSRARTVPDDPPKVTAIAGDRDASADLLEAMRTTDILAPPTDC 529
284165558 452 LTRKRLRAHVDRAADLTEEYDDVSFGDTARENITEAIWDVMATVPDDPPLVRELAGDRDAASDLVDGMRATDIMAPPTRC 531
292655721 429 ATRDDVAEFVSWAADRTKEREDETYGETAQENIADAIWSRMRTVSDEVPKVREVADDRDVARDLLDAMRETDILAPPTDC 508
300711733 421 LSHSALTEYVDRAADMTQERDDVAVGETARENIVTEFWSVMKTVPDDVPLAREVANDRNTARDLVDAMRETDIIAPPTDC 500
289580320 531 LSPISDDLIQAGLEKEFDAEFYASATRDAEVHGGDPFVVEAGIAYGGELPAEGSANVMRFANRVPLVYQRGACATTDVVK 610
169235746 510 LSPIEADQLEAGLRTEFDADFYAAATRDADVHGGDPFIVEAGIAYGGDIDSEGGVQLMRFANRVPLVYQRGACATTDVLG 589
55377343  508 LSPISAELVEEGLRKEFDADFYAASTRDASVHGGDPFIVEAGIAYGGELESEGTVDVMRFANRVPLVYQRGACATTDVVK 587
15790023  510 LSPIEADQLEAGLRTEFDADFYAAATRDADVHGGDPFIVEAGIAYGGDIDSEGGVQLMRFANRVPLVYQRGACATTDVLG 589
76802379  510 LAPISEDLVKAGLKKEYDAEFYTSVTRDASVHGGDPFVVEVGIAHGGDIAVDGSVETLRFANRVPLVYQRGACATVDVLK 589
257388768 520 LAPITAELVEAGLKKEFDADFFAASTRDASVHGGDPFIVEAGIAYGGDIEHD-QAQVMRFANRVPLVYQRGACATTDVVK 598
257051218 513 LAPISERLVEEGLRKEFDADFYAASTRDASVHGGDPFIVEAGIAYGGELDEGGPVDVMRFANRVPLVYQRGACATTDVVK 592
222479739 530 LAPITAELVEAGLRKEYDADFYAAATRDAEVHGGDPFIVEAGIAYGGEIPAEGSVELLRFANRVPLVYQRGACATTDVIK 609
284165558 532 LSPISEELISAGLEKEFDADFYASATRDAEVHGGDPFIVEAGIAYGGDLESEGSVNVMRFANRVPLVYQRGACATTDVVK 611
292655721 509 LSPISAELVEAGLKKEFDADFYAAATRDAEVHGGDPFIVEAGIAYGGELKSEGKIDLLRFANRVPLVYQQGACTITHVVK 588
300711733 501 LAPITDELVEAGLRKEFDAEFYAAATRDAEVHGGDPFIVEAGIAYGGEISAEGSIDVMRFANRVPLVYQRGACATTDVVK 580
289580320 611 SIGWRNYGLDQPGGSGLPNGPVVIMIHVASTNVPFTSESKDAVANVPEIEDEIELAIREAARDLKSFLNKRRSMQKRRKK 690
169235746 590 DIGWRNYNLSQPGGSGLPQGPAVIMVHVASTNVPFTSESKDAIANVPEIEAEIELAVREAARELKSFLQKRQSMRKRQQK 669
55377343  588 SIRWRNYNLDQPGGSGIPKGPAVIMVHVASTNVPFTSESKDAIANVPEMEDEIELAIREAARELKSYLNKRRSMQQRREK 667
15790023  590 DIGWRNYNLSQPGGSGLPQGPAVIMVHVASTNVPFTSESKDAIANVPEIEAEIELAVREAARELKSFLQKRQSMRKRQQK 669
76802379  590 GVNWRNYGLDQPGGSGMPSGPAVIMVHVASTSVPFTSESKDAVANIPEIEDELRLALQQAGRDLQSHLKKQRSLEKRRRK 669
257388768 599 SINWRNYGLDQPGGSGIPNDAAVVMVHIASTNVPFTSESKDAVANIPEIESEIELAIREAARELKSYLNKRRSMQKRRKK 678
257051218 593 TINWRNYGLDQPGGSGIPKGPAVVMIHVASTNVPFTSESKDAIANIPEIEDEIELAIREAARELKSFLNERRSRRQRREK 672
222479739 610 SIGWRNYGLDQPGGSGLPNGPAVISIHIASTNVPFTSESKDALANVPAIEDEIELAVREAARELKSYLNKRRSMQQRREK 689
284165558 612 SIGWRNYGLDQPGGSGLPKGPAVIMVHVASTNVPFTSESKDAVANVPEIEDEIELAIREAARELKSYLNKRRSMQQRRKK 691
292655721 589 DIGWRNYGLDQPGGSGMPNGPAVLMVHVASTNVPFTSESKDALADVPAIQDEVELAIREAARDLKSYLSKRRSLQKRREK 668
300711733 581 SIGWRNYGLDQPGDTGLPNGPAVVMVHVASTNVPFTSESKDAIANVPAIEDEIELAIREAARELKSYLNKQRSIAKRRKK 660
289580320 691 QNVLGTILPEMATKVAEVTGRDEPDIDDAIARIMNNVLVERELEQNgdgqAVSVIVENNSSTNETLEITDIVSAEPRSL- 769
169235746 670 QDVIMDILPTMAEKVGELTGRGGVDVSDSLARIMNNVLVERARSDDg--qTVTLRVENHGTGSVDVDVTDIVSAEPDGV- 746
55377343  668 QDKLATILPEMAEKLTEVTDNDELHIDDSLARIMNNVLVEREVEDD----TVRVRIENNDDTNADVELTDIVTAEPQVT- 742
15790023  670 QDVIMDILPTMAEKVGELTGRGGVDVSDSLARIMNNVLVERARSDDg--qTVTLRVENHGTGSVDVDVTDIVSAEPDGV- 746
76802379  670 QDVIADILPDMAAKLSEVTDREPLDVEDSLARIMNNVLVERTVEES----TVQLSVHNYGDTNVGPEVTDIVSQEPDGA- 744
257388768 679 ENKLATILPEMAEKLATVTGNERLDIDDSMARIMNNVLVEREVEGD----TVRVVVENNDDTNADIDLTDIVTAEPQAT- 753
257051218 673 QDKLGTILPEMATKLTAVTGRAELNIDDSLARIMNNVLLEREREDG----TVSLVVENNDSTNADVEITDIVTAEPANVe 748
222479739 690 QDVLGRILPEMADKVSEVTGRPRPDIDSALARIMNNVSVEREVNDE----TVTLVVENHSDVNEQLEITDIVSAEPTDL- 764
284165558 692 QNVLGTILPEMASKVAEVTGRDEPDIDDAIARIMNNVLVERSVKENgdgqAVSVTVENNSGTNESLEITDIVSAEPTSL- 770
292655721 669 QDVLGRILPQMATKLSEVTGRPEPNIDGALGRIMNNLTVERAVDDG----EVTLTVTNHSNTNESPDITDIVSAEPGGL- 743
300711733 661 QDVLATILPEMATKVAEVTDREPPDIDAALARIMNNVQVSRVVENG----SVVLAVENHSNTAEDLEITDIVSIEPNDL- 735
289580320 770 --SDGATVVEMDGEWFVKWEADVSSGDDAVLEYEVADDASFDLDVKGVETEKLTVKQ 824
169235746 747 --GDDASVVAMDDEYFVKWTPAVAGDDAAELTYSVDADADCELSVSGVADARLTVSE 801
55377343  743 ---NGATVVEMDGEWFVKWSPTVGAGETAVLEYSVTDEAEFTVSVDGIEEEKLTVNA 796
15790023  747 --GDDASVVAMDDEYFVKWTPAVAGDDAAELTYSVDADADCELSVSGVADARLTVSE 801
76802379  745 ---ESATVVEMDGEWFLKWSPTVGGGETATLEYEVDGDAEFDISVEGIEAEKLTVDA 798
257388768 754 ---NGANVVEMDGEWFVKWQTTVAAGDDAVLEYRIDGDAEFDIAVDGVEDEKLTVNA 807
257051218 749 adGDDARVVEMEGEWFIKWSPTVSSGDEAALSYEVSDDAEFDISVEGIAEEKLTVDG 805
222479739 765 ---SDGTVVDMDGEWFVQWKPEVPSGDERELTYAIDGDADFEVSVGGVETEKLTVNA 818
284165558 771 --PDDATVVEMDGEWFVKWEPEVSSDDEATLEYEVADGAEYDLDVKGVETEKLTVKQ 825
292655721 744 --DGEATVVGLDGEWFVKWNPEVPSGETATLTYSVAQDASFDINVDGVETEKLTVNV 798
300711733 736 ---SAGTVIEMDGEWFVKWSPTVPGGETATLEYSVDEEATFDLDVSGVETAKLTVER 789
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