Conserved Protein Domain Family
PRK13766

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PRK13766: PRK13766 
Hef nuclease; Provisional
Links
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Statistics
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PSSM-Id: 237496
Aligned: 56 rows
Threshold Bit Score: 807.559
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
73668740   11 GFMKHPLIKPNTVEQRLYQLNLAGKALEGSSLVVLPTGLGKTIIALFVIVSRL-QRFGGKALVLSPTKPLVEQHAAFFKK 89  
57640956    1 ----MQYLRRDLIEPRVYQEVIYARCKEANCLVVLPTGLGKTLIAMLIADYRL-SKYGGKVLMLAPTKPLAVQHAESFKK 75  
41615176    1 ----------------------------------MPTGLGKTVIALMLIEYFKqKYPDKKILFLAPTKPLVNQHVEFLRK 46  
14520497    1 --MNTMYLRKELLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRL-NKYGGKVLMLAPTKPLVLQHAETFRK 77  
18978387    1 ----MMLLRRDLIQPRIYQEVIYAKCKETNCLIVLPTGLGKTLIAMMIAEYRL-TKYGGKVLMLAPTKPLVLQHAESFRR 75  
14591755    1 --MNLMYIRKDLLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRL-DKYGGKVLMLAPTKPLVLQHAETFRK 77  
212224218   1 -----MYLRRDLIQPRVYQEVIYARCKESNCLVVLPTGLGKTLIAMLIADYRL-QKYGGKVLMLAPTKPLALQHAESFKK 74  
240103224   1 ----MSYLRRDLIEPRVYQEVIYARCKERNCLVVLPTGLGKTLIAMLIADYRL-SKYGGKVLFLAPTKPLAMQHAESFRR 75  
242398676   1 -----MYLRKDLIQPRVYQEVIYAKCKDKNSLVVLPTGLGKTLIAQLIADYRL-SKYGGKVLMLAPTKPLALQHRESFLK 74  
296109929   1 MYVEHKFIKPNKLEARIYQQLIAASALKDNTLVVLPTGLGKTAIAALVIAGLL-TKKDGKVLIIAPTRPLVEQHYRTFKD 79  
73668740   90 VMALpedKILTFTGSIAPAEREKLWAQGELIVSTPQVIENDLLTKRISLEDVTHITFDEAHRAVGNYAYTFIAEKYFESA 169 
57640956   76 LFNIppeKINVLTGELSPKQRAEVWKNSVVITATPQTVENDILTGRISLEDVVLLVFDEAHRAVGNYSYVFIAKEYLKTA 155 
41615176   47 YSDIdptKIVGISGDIPKEKRVKLY-NADVIVATPQTIKNDLANNLIDLNKFSLIIFDEAHRAVGNYSYTYIARNFNNR- 124 
14520497   78 FFNLppeKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLLTGKINLEDVVLVIFDEAHRAVGNYAYVYIAREYLNQA 157 
18978387   76 LFNLppeKIVALTGEKSPEERSKAWARAKVIVATPQTIENDLLAGRISLEDVSLIVFDEAHRAVGNYAYVFIAREYKRQA 155 
14591755   78 FFTLppeKIVALTGEISPNERVRAWARAKVVIATPQTIENDLLVGRISLEDVTLIIFDEAHRAVGNYAYVYIAKEYLKQA 157 
212224218  75 LFDIppeKINVLTGELSPKTRQEIWEKSVIITATPQTIENDILTGRISLEDVVLLVFDEAHRAVGNYSYVFIAREYLKTA 154 
240103224  76 LFNLppeKINVLTGELSPEKRAELWRKSVVVTATPQTVENDILTGRISLEDVVLLVVDEAHRAVGNYAYVFIAREYLKTA 155 
242398676  75 LFNIpdeRINTLTGEIPPEKRAEIWRKSVVITATPQTIENDLVVGRITLEDVVLLVFDEAHRAVGNYGYVYIAKEYMRQA 154 
296109929  80 ILNId--GIVAITGKIPPAKREKIYREGKIFIATPQVIENDILSGRLKVDDFILLIADEAHHTVGNHAYAFVAKSFKDKC 157 
73668740  170 KNPHVLGITASPGSSDEKISEVCQALHIENVSVKTEKDKDVRPYVQEKKIEWFQVQLPSEMAEIRGYLEKIFDDRLVTVR 249 
57640956  156 KHPLVLGLTASPGSDEEKIREIVRNLGIERIEIRTESSPDVKPYVQKIAFEWVKVDLPGIYKEVRSILREMLKESLKPLA 235 
41615176  125 ----IVGLTASPGSDEEKIKEIIENLKIERIEYRNEDSSDVRPYVKKKVIKYIGVALDKEILTASSLIQEAIEIRKKKLE 200 
14520497  158 KNPHVIGLTASPGSSQEKILEVLRNLGIEHIEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLKPLA 237 
18978387  156 KNPLVIGLTASPGSTPEKIMEVINNLGIEHIEYRSENSPDVRPYVKGIRFEWVRVDLPEIYKEVRKLLREMLRDALKPLA 235 
14591755  158 KNPHVIGLTASPGSTPEKIMEVLRNLGIEHIEYRSENSPDVKPYVQGIKFEWVKVELPELYKEVRKLLRDMLRDSLKPLA 237 
212224218 155 KHPLVLGLTASPGSDEVRIREIINNLGIERIEIRTESSPDVKPYVHRIAFEWVKVDLPGVYKEVRSLLRGMLKESLKPLA 234 
240103224 156 KHPLVLGLTASPGSDEEKIREIVENLGIERIEVRTESSPDVKPYVHRIAFEWVRVELPGIYREVRKILREMLKDSLKPLA 235 
242398676 155 KHPVILGLTASPGSDEAKIRSIVKNLFIEHIEVRNENSPDVRPYVQGIRFEWIKVELPEIYKEIRKLLRKMLRDSLKPLA 234 
296109929 158 H---ILALTASPGHDVDKVMEICENLGIKRIEFRDESDEDVKPYVAKVRMIPIRVELLEEFKKALKLLDDALKERLKFLK 234 
73668740  250 DLGFSVGSRkyVSKKDLLLLQKKLQGEIRI--GGDpAVFTAMSVLAEMLKVNHAVEMIETQGLEPLRKYLEKLDAEAssn 327 
57640956  236 QFKLVSTYSpdISKKEVLQAGSKINQEVAR--GNY-ELGRLRMHQAKAVKLLHALELLETQGLTALRAYLKKLKEDKr-- 310 
41615176  201 ELGILKRKI-----KDIALLMEELKKKQAYslDER--VKDAIIIGSEILILFHALKTLQTQTYRAFLKFCENLFENAq-- 271 
14520497  238 EAGLIESASadLPKKEILRAGQIINEETAK--GNH-DLRKLLLFHAMALKLHHAIELLETQGLSALRVYLKKLYEEAkt- 313 
18978387  236 ETGLLESSSpdIPKKEVLRAGQIINEEMAK--GNH-DLRGLLLYHAMALKLHHAIELLETQGLSALRAYIKKLYEEAka- 311 
14591755  238 EAGLLDSTSadIPKKEILRAGQIINEEMAK--GNH-DLRKLLLFHAMALKLHHAIELLETQGLSALRVYLKRLYEEAka- 313 
212224218 235 QFKLVSSYSpdISKKEVLQAGSKINQEVAR--GNY-EIGRLRMYQAKAVKLQHAIELLETQGLTALRAYLKKLREDKr-- 309 
240103224 236 DAGLVSSPSpdISKKEVLQAGSKINQAMAK--GDY-SAGYLKKHQAKAMKLHHAIELLETQGLTALRNYLKKLREDR--- 309 
242398676 235 EAGLIDDSSpdIPKKDVLKVGQVINAEMAK--GNY-EIGKLMLYQAKALKLHHAIELLETQGLSALRAYLKKLYEESkk- 310 
296109929 235 DHGVIDSIN--VTKTELLELNNKLFSY-----DDE-VKYELIKKCSEALKLMYAKELLESQGKDVFLKYIEKLSLQR--- 303 
73668740  328 saSKASKRLMDDLYMRKALY---RVKECEVEHPKLELARKLVSKQLKgSPDSRVIVFTNYRDTAEIVVNALsEIPEIVPI 404 
57640956  311 --TKSSKELMEDPRMRKVIYllvQAKESGLDHPKMEKLKELVKEQLGkKPSSKIIVFTNYRDTGKKIVEEL-RSMGITAE 387 
41615176  272 --KLSEKNVAEDVRLKKAYLyvkDLVKQGKEHPKINALLEIIKK----NKDKKIIVFAQLTDTVMQITELL-NKNNIKAV 344 
14520497  314 gsTRASKELFLDRRMKKALAlliQAKELGIDHPKMEVLKELVKEQLSkKENSKIIVFTNYRETARKVVEEL-TKEGIKAK 392 
18978387  312 gsTKASKEIFSDKRMKKAISllvQAKEIGLDHPKMDKLKEIIREQLQrKQNSKIIVFTNYRETAKKIVNEL-VKDGIKAK 390 
14591755  314 gsTRASKELFLDKRMKKALAlliQAKELGIDHPKMEVLKGLIREQLKrKENSKIIVFTNYRETAKKVVEEL-MKDGIKAR 392 
212224218 310 --TKSSRELMEDPRMRKVIYllvQAKELGIDHPKMEKLKELVKAQLEkKPNSKIIVFTNYRDTGKKIVEEL-RAMSVSAE 386 
240103224 310 --SKSSRELMEDPRMRKVIYllvQAKELGLDHPKMEKLKDLIKKQLErKPDSKIIVFTNYRDTGKKIVEEL-RNLGVSAE 386 
242398676 311 grAKSTKELIQDPRMKKAVAllvQAKELGLDHPKLDKLKELIRSQLKkKPSSKIIVFTNYRETAKKIVKEL-LEDHIKAV 389 
296109929 304 --SKSAKNVVCDERVKKAVN---LLKSLNVEHPKYPKLLELIKSILEkNKDERIIVFAQYRDTVDKIVSLL-EKNGIKAI 377 
73668740  405 RFVGQASRRKDKGLTQKQQVEVLDKFRAGEYNVLVATSVAEEGLDIPSTDLVLFYEPIPSEIRSIQRKGRTGRQHKGRVI 484 
57640956  388 RFIGQASRKDDRGMSQREQKEVLDRFSRGEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSIQRRGRTGRHRPGRVV 467 
41615176  345 AFTGK------KLMTQKKQIETLDKFRANIYNVLVASSVAEEGLDIPKVDLVIFYEPIPSAIRAIQRKGRTGRLNYGEVI 418 
14520497  393 RFVGQATKENDRGMSQREQKLILDSFARGEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVV 472 
18978387  391 RFVGQASKENDRGLSQREQKLILDEFARGEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSIQRRGRTGRHMPGRVI 470 
14591755  393 RFVGQASRENDRGMSQKEQKLILDAFARSEFNVLVATSVGEEGLDVPEVDLVIFYEPVPSAIRSVQRRGRTGRQKPGRVV 472 
212224218 387 RFIGQASRSNDRGMSQKQQKETLERFSRGEFSVLVATSVGEEGLDVPEVDLVIFYEPVPSAIRSIQRRGRTGRHRPGRVV 466 
240103224 387 RFIGQASRGTDRGMSQKEQKEVLDRFSRGEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSIQRRGRTGRHRPGKVV 466 
242398676 390 RFVGQASKENDKGLSQKKQKQVLNLFSQGEFNVLVATSVGEEGLDVPEVDLVIFYEPVPSAIRSIQRKGRTGRHKPGRVV 469 
296109929 378 KFIGQSCRD-GKGMSQKQQVEAIERFKRE-GQVLVSTSVSEEGIDIPAVNYVIFFEPVPSEIRTIQRRGRAMRGEGGTCY 455 
73668740  485 ILVTKGTRDEAYYWSSKSKEKRMLNSMHglealldpkdskqglklsdfeskafipadtqneagnetkinnrfenanitqe 564 
57640956  468 ILMAKGTRDEAYYWASRRKEKGMFDAIKkiareleklqrarikaqg-----------------------eegkihagvek 524 
41615176  419 ILYSKNTLDEKALWASIRKEKKMYEILEklskevkpkk------------------------------------------ 456 
14520497  473 ILIAQGTRDEAYYWSSKHKERQMRETIRmvs------------------------------------------------- 503 
18978387  471 ILMAKGTRDEAYYWSSRQKEKIMQETIAkvsqaikkqk---------------------------------------qts 511 
14591755  473 ILMAQGTRDEAYYWSSRQKEKIMRETIRmvs------------------------------------------------- 503 
212224218 467 ILMAKGTRDEAYYWSSRRKERGMFEAIRkiarelea-------------------------------------------e 503 
240103224 467 ILMAKGTRDEAYYWSSRRKEKGMFDAIKrvarelekaqqkrg--------------------------------kirert 514 
242398676 470 ILMAKGTRDEIYYWSSRHKEKQMISILEkve------------------------------------------------- 500 
296109929 456 ILISKGTSDEAYYWSALKKEREMKRTLRaickaiekklkek----------------------------------ygedp 501 
73668740  565 nqnpmqkSNDLDVNLSGFVNSRGkavdsnvfadnkdeavdsssfadigdratdvrylaadcgdltvgsrdmgtgsdynka 644 
57640956  525 skgsvdvSKGKIAPLDAFLKPKKventeireskavgkaapqaseek---------------------------------- 570 
41615176      --------------------------------------------------------------------------------     
14520497  504 ----qaiKREKQLSLESYVKKDTekemeree------------------------------------------------- 530 
18978387  512 lvdfvreKESEKTSLDKWLKKEKeeateke-------------------------------------------------- 541 
14591755  504 ----qmvRKERQLSLESYVKREVneeike--------------------------------------------------- 528 
212224218 504 mkeredmKRGKITSLDAFLKPKKkpaeekaegieeaekpsegkveky--------------------------------- 550 
240103224 515 kervempSRSKITSLDAFLKVGKakkaggevketkesekknesqtpq--------------------------------- 561 
242398676 501 ----dmvKKEKQASLLGFVKSKEkekgkikeikekieekvev-------------------------------------- 538 
296109929 502 ikkeyleEKEDKEEKIETKEEKKeeekkeepkeekrkltlldf------------------------------------- 544 
73668740  645 neeineencgvgkeeerkknrswkesekgkeqkneekskeenvkerqktfvyfetlsgkkteltpetaaevskietnsES 724 
57640956  571 --------------------------------------------------------saekpketteelpikpifvrkpKG 594 
41615176  457 ---------------------------------------------------------------------eqtlnevlgFR 467 
14520497  531 ----------------------------------------------------------------------keerkgerEG 540 
18978387  542 -----------------------------------------------------------------------ekkvkaqEG 550 
14591755  529 -------------------------------------------------------------------------ekketGG 535 
212224218 551 ------------------------------------------------------ekaepskeelyeklpikpvfvrrpKG 576 
240103224 562 ------------------------------------------------------iqekrtaenrdkeipikpifvkkpKG 587 
242398676 539 -----------------------------------------------------------pkeevyeklpikpifvrrpHG 559 
296109929 545 -----------------------------------------------------------lkssgkeekreeekketgkKK 565 
73668740  725 PKIVVDFREAKSGVANVLDKLGVEVIFTTLEIGDYVVSDRLAVERKRTDDFVNSLVDgkRNLFAQLSDLTRVYQKPVLII 804 
57640956  595 IVVYVDSRELRSGVPKHLRELGAEVEVRTLDVADYVVSEEVGIERKSANDFIQSIID--GRLFDQVERLKRAYEKPVIII 672 
41615176  468 YKIIADQREQNSLVVDALKKLGIGVKIENLEVGDYIVGD-VVIERKTIRDFVDSIID--NRIWDQMNKLSQ-LDKKLLIL 543 
14520497  541 VKVVVDSRELRSEVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIID--GRLFDQVKRLKDSYPRPVVIV 618 
18978387  551 VKVVVDSRELRSEVVKRLKLLGVKLEVKTLDVGDYIISEDVAIERKSANDFIQSIID--GRLFDQVKRLKEAYSRPIMIV 628 
14591755  536 IKVVIDSRELRSEVVKKLKTLGIKIEVRTLDVGDYIVSEDVAIERKSANDFIQSIID--GRLFDQVKRLKEAYPRPVIII 613 
212224218 577 IVVYVDSRELRSGVPKHLRGLGAEVEVKTLDVADYVVSEEVGIERKSANDFIQSIID--GRLFDQVERLKKAYEKPVIII 654 
240103224 588 IVIYVDSRELRSGVPKILKELGAEIEVKTLDVADYVVSEEVGIERKSANDFIQSIID--GRLFDQVERLKRAYEKPVIII 665 
242398676 560 IVIYVDSRELKSQVPKILKELGAHLEVKTLDIGDYIVSEDVVVERKAANDFIQSIID--GRLFDQARRLKEAYLKPIIII 637 
296109929 566 IKIIVDVRE--KGMAKLL-SEKAEVELKTLELGDYIVSDRVVIERKTDEDFVNSIID--KRLFNQLKDLKK-VERPILII 639 
73668740  805 EGtE--LFTSRQINPNAIYGSLISIAIDFGVSLLYSRDEEETAAILKMLAKREQIGNKREVNPHGKKSASTLPEQQEYLV 882 
57640956  673 EG-E--LYGIRNVHPNAIRGAIAAVTLDWGVPILFSSGPEETAQFIYLMAKREQEERKKEVRLRSEKKALTLAERQRLIV 749 
41615176  544 EG-EedPYFIRDVNPNVIRSVILTLSLK-GIPIIRTKNPIDTAYYIKVLSEKQN---KLPQIPKIKKKELTPKE----VL 614 
14520497  619 EG-Q--LYGIRNVHPNAIRGAIASIVIDFGVPIIFSSNPEETANYIFFMARREQEERRREVRVRGEKKALTLAERQRLIV 695 
18978387  629 EG-S--LYGIRNVHPNAIRGAIAAVTVDFGVPIIFSSTPEETAQYIFLIAKREQEEREKPVRIRSEKKALTLAERQRLIV 705 
14591755  614 EG-Q--LYGIRNVHPNAIRGAIASIVLDFGVPVIFSSSSDXTAHYIFFMAKREQEERKREVRIRGEKKALTLAERQRMIV 690 
212224218 655 EG-Q--LYGIRNVHPNAIRGAIAAVTLDWGVPILFSSGPEETAQFIYLMAKREQEERKKEVRLRSEKKALTLAERQRLIV 731 
240103224 666 EG-E--LYGIRNVHPNAIRGAIASVTVDWGVPVLFSSGKEETAQFIYLLAKREQEERKKEVRLRSEKKALTLAERQRLIV 742 
242398676 638 EG-E--LYGIRNIHPNAIRGALTALSVDWDIPVLFAKDAAEVANYIYLIAKREQEERKKEVAVRSEKKALTLADRQRLIV 714 
296109929 640 EG-N----NFSRIHENAIKGAILSIILDYRIPIIFTKDREETADYIIKIAEREQLKEKRPVSIRYGKRAMTLQERQKFIV 714 
73668740  883 SAIADIGPKAARNLLLHFGSVEAIMKADAKELKKVNLIGPKRATKIRELIEAPYKG 938 
57640956  750 EGLPNVSATLAKRLLKHFGNVERVFTATEEELKEVEGIGPKKAREIRRVITGTLR- 804 
41615176  615 ASFPGIGEKSAEELLKRYKTIKNVVNASLSGLSII--LGEKRAKKLKEFLEKEYQ- 667 
14520497  696 ESLPHVSATLAKRLLKHFGSVERVFTASVPELMKVEGIGEKIAREIRRVITSPYTE 751 
18978387  706 EGLPHVSATLARRLLKHFGSVERVFTASVAELMKVEGIGEKIAKEIRRVITAPYIE 761 
14591755  691 ESLPNVSTTLARRLLRHFGSVEKVFTASVPELMKVEGIGEKIAREIRRVITSPYIE 746 
212224218 732 EGLPNVSATLAKRLLKHFGNVERVFTATEEELQEVEGIGPKKAREIRKVITAPYVE 787 
240103224 743 EGLPNVSSTLAKRLLRHFGNVEKVFTATEEELKEVEGIGEKKAREIRKVITAPYVE 798 
242398676 715 EGLPNVSAVLARRLLKHFGNVERVFTAKESELIQVEGIGEKIAKEIRRVITSPYEE 770 
296109929 715 ESLPDVGGALAERLLEHFKTVENVFTASERELMRVEGVGEERAKKIREVLTTEYKK 770 
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