Conserved Protein Domain Family
PRK07220

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PRK07220: PRK07220 
DNA topoisomerase I; Validated
Statistics
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PSSM-Id: 180892
Aligned: 10 rows
Threshold Bit Score: 1157.59
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
21229178    1 MHLIVTEKNIAARRIAAILAPKSPKKERVSGVDVYRYEigsgENRQETAVVGLSGHIVGIDFPKEYNNWQKVDARDLIDA 80 
20091341    1 MHLIVTEKNIAARRIAAILAPKSPKKERVSGVDVYRYElgkgKSRQETAVVGLSGHIVGIDFQKEYNNWQKVDARALIDA 80 
73669895    1 MHLIVTEKNIAARRIAAILAPKNPKKDRVSGVDVYRYEivsdEEKQETVVVGLSGHIVGIDFPKEYNNWQKVESKTLINA 80 
108804786   1 MRLIISEKANAARKIAQFLAEGPVKEGKHRSVPYHTFT----WRGEECVSVGLKGHVLNPEYPEEYSNWQKVDPRELIDA 76 
91772172    1 MHLIIAEKHIAAKRIAKILAPKEPKQVRVSGMDTFEYKn--pDAEDRIIVMGLSGHIVQLDFPKAYNNWQKIDANELIDA 78 
116753908   1 MHLIIAEKHDAAKRISEILAGKKPTVTKVSGIDTFRFD--------DRVVIGLSGHIVGLDYPECYNNWHKVDYRDLIRA 72 
147919417   1 MHLIITEKNITAKKIAQILFGKGTKETKVEGVSVY--------SSGDTSIVGLSGHIVNIDFPEQYNNWSVTAPKDLIRA 72 
282165112   1 MHLIVTEKNITARKIAQLLL-GSAKERKVDGVSVY--------EGDDTAVVGLSGHIVNIDFPDEYNNWQSTAPKDLIWA 71 
298674647   1 MHLIIAEKHIAAKRIAAILAPKKPKKVRVSGVDTYEYE----DNEDDKIVMGLSGHIVELDFPKEYNNWQKVNAEDLIDA 76 
294495850   1 MHLIIAEKQIAARRIASILSPKKPQKKRISGIDSYEFG-----NDEKTIVIGLSGHIVQLDFPPAYNNWQKVEAKELVDA 75 
21229178   81 EITTTPINRKIVTALKSLGKEADRVTIATDYDREGELIGVEALNIIKKVNPKI--PFDRVRYSAITPKAIEAAFSNPTNV 158
20091341   81 EITTTPINRKIVTALRTLGKEADRVTIATDYDREGELIGVEALNIIKKVNPEV--PFDRVRYSAITPKAIDAAFTNPTSV 158
73669895   81 DIITTPINRKIVTALKGLGKKASRVTIATDYDREGELIGVEALNIIKQVNPDV--PFDRVRYSAITPKAIEAAFSNATDV 158
108804786  77 RILKSVSEKGVAAAVRSLAKKADRVIIATDFDREGELIGVEALSLAFEANPALmdHVERARFSALTKGEVTRAFENLVEV 156
91772172   79 EVITTPTHVKIVAALRKLGKEATHVTIATDYDREGELIGVEALNIIRKVNPDV--EFDRVFYSAITKTEIEGAFANPASI 156
116753908  73 EIVSRPTQERIVSALRKLGREADRVTIATDYDREGELIGVEALCILQEVNPSI--KADRVRFSAITKSEILRAFAQPEEV 150
147919417  73 ETEMRYTHKKIATALKKLSKDATSVTIATDYDREGELIGVEAYRIISGFKPDI--KFDRAKFSAITKPEIDRAFSNRVPL 150
282165112  72 NTEMRYTQKKIATALKKLAKEATHVTIATDFDREGELIGVEAYHIIKDAAPAA--KFDRARYSAITRQEIEHAFANTVPI 149
298674647  77 ELITKPTQVKIVAALKKLGKKASKVTIATDYDGEGELIGVEALDIIKKVNQDI--QFDRVKYSAITEKEIKNAFSNPVNV 154
294495850  76 ELIITPTHAKIVSALKKLGKKATKVTIATDYDREGELIGVEALNIVKGVNESI--EYERAVYSAITPAAIKEAFENTTKI 153
21229178  159 DFNLADAGHSRQVIDLVWGAALTRYISLAAGRLGKMFLSVGRVQSPTLSLIVDREKERNIFVPTPYWEIHVELEDaAGET 238
20091341  159 DFDLADAGHSRQVIDLVWGAALTRYISLAAGRLGKMFLSVGRVQSPTLSLVVDREKERNIFVPTPYWEIHVELETkAGET 238
73669895  159 DFNLADAGHSRQVIDLVWGAALTRYISLAAGRLGKMFLSVGRVQSPTLSLIVDREKERNVFVPTPYWEIYAELQNtEGKT 238
108804786 157 SRELADAGEARQDIDLIWGATLTRWVSRAVKRYGSAFLSVGRVQSPTLVLIAERELERRAFVPEPYWEVEARLQN-GGGP 235
91772172  157 DFDLADAGHSRQVIDLVWGASLTRYLSISAGRLGKLFLSVGRVQSPTLALIVDKEKERQAFVSKPYWEVNATLKDnDDAL 236
116753908 151 DFNLAASGEARQIIDLVWGAALTRFISITSGRLGKEFLSVGRVQSPTLALIVDREKEIESFQPKPYWEIYADLEK----G 226
147919417 151 DFNLAAAGEARQKIDLVWGAALTRYISLTCGRLGKSFLSVGRVQTPLLALLVDREKEIKAFVSTPYWEIYATLGN--GTD 228
282165112 150 DFDLAAAGEARQKIDLVWGAALTRYISLTCGRLGNSFLSVGRVQTPLLALIVDREKDIKAFTPTPYWEIYATFTN--GEE 227
298674647 155 DFNLADAGHSRQVIDLVWGASLTRYISLSAGRLGKMFLSVGRVQSPTLALIVDREKEREAFVPDPYWEVYATLANsNGEE 234
294495850 154 DFNLADAGHSRQVIDLVWGASLTRFISLASRRLGKQFLSVGRVQSPTLALIVDREKEREAFVPTPYWEIYVDLSK-NGEI 232
21229178  239 FSAQHSTRRFLDKEEASKVFRKL--GKKAELKEIEKGTKTDQPPTPFNTTGFISAANSIGLSPANAMRIAESLYTNGYIS 316
20091341  239 FSAQHSTRRFLDKEEATAVFKKL--GKKAELKEIEKGTKSDLPPTPFNTTGFISAANSIGLSPANAMRIAESLYTNGYIS 316
73669895  239 FSAQHSTRRFLDKKEATKAFKKL--GKKAELKGIEKGKKTDQPPAPFNTTGFISAANSIGLSPANAMRIAEALYTNGYIS 316
108804786 236 FVARHARGRFKEEAEARRALENL--SETAVVTEVRQREATRPAPAPFNTTAFLTAAANIGVSPSRAARIAEDLYTEGYIS 313
91772172  237 VNVQHKNSKFWEKEEADAVMEVI--GDKASVSSVDSSKKTDKVPTPFNTTEFIGAASSIGFTASNAMRIAESLYTNGFIS 314
116753908 227 IRVRHSKSRIWTRDEVDRILNSL--SDVARVRSISKGERRDRPPTPFDTTSFISAASSIGFTAANAMRIAESLYTNGYIS 304
147919417 229 FTAKHECNRFEDKKKADSVRAKL--GSTGTVVEYKKDARSDAAPIPFSTTEFIRAASSIGFSAANAMRIAENLYVNGWIS 306
282165112 228 FVAGHTGNRFTEKAKAEGIMARL--GRTGKVADYKKEPRVEYPPIPFSTTEFIRAAASIGFSAANAMRIAENLYVNGWIS 305
298674647 235 FVTQHKTQRFWDKNQVNSVVDKLkdCKTAEVTSVEKSTKQDKPPSPFNTTEFISAANSVGFTASNAMRIAETLYTNGYIS 314
294495850 233 FKIRHKNTRFWEKEEANRVFRLI--GNEALVSSLETSTKEDKPPTPFNTTEFIRAANSIGFTPANAMRIAESLYTNGYIS 310
21229178  317 YPRTDNTVYPDTLDLKAQIEIFKE-GPFKEYANTLLEKPELVPTRGKKETTDHPPIFPASLAKESDLKEDEWKVYELVVR 395
20091341  317 YPRTDNTVYPETLDLRAQIEIFTE-GPFKEFADALLEKAELVPTRGKKETTDHPPIYPASLAKESELKEEEWKVYELVVR 395
73669895  317 YPRTDNTVYPETLDLRAQIEIFKE-GPFKEYADALLEKAELIPTRGKKETTDHPPIFPASLAKESDLKEDEWKVYELVVR 395
108804786 314 YPRTDNTVYPESLDLREVLGFLAEvEGVGDYAGRLLGAGRLTPTRGRRQTTDHPPIYPTGRASRAELREDQWKIYQLVVR 393
91772172  315 YPRTDNTVYPASIDLRAQIEIFSK-GPFREYAQKLLAKDELVPTRGKKETTDHPPIYPASLAKKSELNEQDWKLYELVVR 393
116753908 305 YPRTDNTVYPPSIDLRSLLEMLSS-GPFREDALELM-KGSITPTKGKRSTTDHPPIYPTSVADKDDLKEDQWKIYELVVR 382
147919417 307 YPRTDNTVYPSSLNLRDVLQNFAA-GEFGEYARKLLAMKTLVPTRGKKETTDHPPIYPVSSAKKSDMADDEWRVYELVVR 385
282165112 306 YPRTDNTVYPASLNLKEIVAQFAG-GEFGKYAQRLLEQSSFKPTRGKKETTDHPPIYPVASARKSEIKADEWRVYELVVS 384
298674647 315 YPRTDNTVYPDSLDLRNLIAMFKS-GQFKQYAQYLLNKSNLVPTRGKKETQDHPPIYPTSAAKKSELNEDEWKIYEMVVR 393
294495850 311 YPRTDNTVYPSTIDLREQIEMFSK-GHFSEYAKKLLAKKELKPTKGKKETTDHPPIFPASVAKKAQLKEDEWKLYELVVR 389
21229178  396 RFFATFAGPSIWETMRLKLDIEGEEFRANGARLLEPGWRWYYPYNAPEDRLLPELKESDLLKVIKKEMLDKETQPPGRYG 475
20091341  396 RFFATFAGPSTWETMRLRLEINAEEFRANGARLLEPGWRWYYPYNVPEDRLFPELSEGEILKVIKKEMLDKETQPPGRYG 475
73669895  396 RFFATFAGPSEWETMRLKLDINGEEFKANGARLVEQGWRWYYPYNAPEDRLFPELHEGDSLKVIKKDMQDKETQPPGRYG 475
108804786 394 RFLATLSGPAKTLRTTLRFESGGEPLVAGGTVVTEEGWLAVYHYGRRRDEELPRLSEGDEVRVAEAELLAKETQPPGRYG 473
91772172  394 RFFATFADEAEWETMKVRFDISGEEFKANGARLVHQGWRWYYPYNAPQDRLLPALSEGDILDVTGKEMLDKETQPPGRYG 473
116753908 383 RFFATLSGECVWETTSISFDIGDEVFRANGSRILDLGWRRYYPYSRAEENVLPPLREGEGLKVLSHEVLSKETQPPARFG 462
147919417 386 RFFATLAPAATWETRNTTVDISGEKFKASGSKLTEAGWRYYYPYGMPKEEVLPALEVGETLKVKKIEMPEKMTQPPTRYG 465
282165112 385 RFFATLAPPAEYEVRNVCVDVNGERFKATGSMLSTPGYRLYYPYGMAKEELLPELSVGQELAVKNAAMDEKLTKPPVRYG 464
298674647 394 RFFATFADPAKWETMKVKFDIGSEEFRAKGARLISPGWRWFYPYNSPEDKILPPLKKGEVLTVKSSKVADKETQPPGRYG 473
294495850 390 RFFATFAENAEWETMKVRFDINEEEFRANGSRLVKPGWRWYYPYNAPEDRLIPALEEGEILPVNDKEILDKETNPPGRYG 469
21229178  476 QGRLINIMEELGLGTKATRHEIISKLYSRAYIHGNPVQPTNTSFAVMDTLEKYSPTITKPDMTKLLEENMDKIAEGKIKE 555
20091341  476 QGRLINIMEELGLGTKATRHEIISKLYSRAYIHGNPVQPTNTSFAVVETLEKYSPTITKPDMTKLLEENMDLIAEGKIKE 555
73669895  476 QGRLINIMEELGLGTKATRHEIISKLYSRAYIHGNPVQPTNTSFAVMDTLEKYSPTITKPDMTKLLEENMDRIAEGKIKE 555
108804786 474 QGRLIRLMEDLGLGTKATRPGIIQNLYDRGYIHGDPIVPTETGMAVAKALKDFASEIASHEMTARLEKSMDAISEGRVSK 553
91772172  474 QGRLIKLMEDLGLGTKATRHEIISKLYSRAYVHGNPLQPTKTSFAVIEALEKYAPTITKHDMTSQLEEDMDSIAEGKVKE 553
116753908 463 QGRLVKLMDELGLGTKSTRHDIISKLYARAYIHGNPIRPTKTAYAVVDTLQRHAPAITKPEMTRTLENDMLKIAERKITK 542
147919417 466 QGRLVKMMEDLGLGTKSTRHEAIQKLYARNYVHGNPPQPTNTAIAVVDALERYADLITKPDMTSKLEQDMDLIADGKIKE 545
282165112 465 QGKLVKMMEDLGLGTKSTRHEAIQKLYARNYVHGNPPVPTNTAFAVVGALEKYADLITKPDMTSRLESDMDSIAEGKIKE 544
298674647 474 QGRLVRIMEELGLGTKATRHEIISKLFSRAYVHSNPLQPTKTAFAVIDALENYAPTITKHEMTSKLEEDMEKISEGKIKE 553
294495850 470 QGRLIKMMEDMALGTKATRHEIISKLYSRAYVHGNPLQPTQTAYAVVEGLENYAPTITRPDMTSSLEEDMDRIAEGNTSE 549
21229178  556 EAVLEESREMLKQVFSELDKNRDNIIESLQAGLREDKIIGDCSLCGNELMIRRSKRG-SRFIGCSNYPNCTFSLPLPKSG 634
20091341  556 DTVLEESREMLQQVFSELDKNRDKIIESLQAGLREDKIIGNCSLCGNELMIRRSKRG-SRFIGCSNYPNCTFSLPLPKSG 634
73669895  556 AAVLEESRDMLKQVFSELDKNREKIVESLQAGLREDKIIGTCSSCGNELIIRRSKRG-GRFIGCNNYPNCTFSLPLPRSG 634
108804786 554 DSVVEESRELLRRVYDHLESSEEKFADIVWNGIRGDETLGPCPNCGRNLVVRRNRRNrKRFAGCEGYPECRTTFPLPQKG 633
91772172  554 DNVLKESRTMLHEVFTELANNSENISESLRAGLREDKVIGECSECGSKLMVRRSKRG-SRFIGCNGYPDCNFSLPLPKSG 632
116753908 543 GEVIEESRQMLEAVFDELLAHRKEIEDSLREGLRVDRIVGKCRLCGSDLIIRRGRRG-ARFVGCSGYPECRFTLPLPRGG 621
147919417 546 DAVVDESQNMLETIFGVLDKNHDEIREVLFDGLREDKILGKCQTCGSDLMVRKSKKG-GRFIGCTGYPNCTFSLPLPPSG 624
282165112 545 EAVVQESQGMLETIFDDLDKNHNDIREVLYEGLREDRRIGKCPSCGKDLYVRKSKKG-GRFIGCEGYPECNFILPLPRMG 623
298674647 554 DEVLKESRDMLKSMFSELESNRDNITQSLRNGLREDKVIGTCPECESRLMVRRSKRG-SRFIGCDGYPDCTFSLPLPKSG 632
294495850 550 ENVLQQSRDMLTDVFKELEDNREKISESLREGLRKDKIIGKCPDCGCDLIVRRSRRG-SRFIGCEGYPDCTFSLPLPKSG 628
21229178  635 QIIVTDKLCEAHGLHHIRIINQGKRAW----DLGCPQCNFIEWQKTQKEEQAQQPKKEKPKSIKDLEGVGKATAGKLEEA 710
20091341  635 QIVVTDKQCETHGLHHIRIINAGKRPW----DLGCPQCNFIEWQKTQKEKQAQQPKKEKPKTIKDIEGVGKATAGKLEEA 710
73669895  635 QIIVTDKVCEVHGLHHIRIINSGKRPW----DLGCPQCNFIEWQKTQQEEQAQQPKKEKPKSIKDLEGVGKATAGKLEEA 710
108804786 634 DIIPLGTACEACGLPEIKVL-GGRRPWvtciNMDCPKKQ----EQRRSREETQAGGEEPSEGQRDRKRLEKSTT------ 702
91772172  633 QIIVTEKTCEEHGINHVKIINPGKRPW----ELGCPQCNFIEWKKTQEEEKAKQPKVPIPDKITDVPGIGKVTAEKLKNA 708
116753908 622 MIVVTERRCETHDMNHIRIINRGKRPW----DLGCPYCNFNNWQAKKGSKTQRMPE------LDDISGIGPKSRERLESA 691
147919417 625 TIVATNKVCERHGLSHIKITTGGKKPW----ELGCPQCNFEEWQKKKKEAAAAPGEATTGTATAPKKSAPKKVMAKTGGS 700
282165112 624 TIIVTEKNCDKHGISHIRIVNGGSKPW----DLGCPQCNYEEWQKKNAAEKVTPVRKSSEPAKKPARKTTKKKAADDKGA 699
298674647 633 QIIVTDKVCEDHGINHIRVNIPGKRPW----NLGCPHCNFIEWQKEQENNKNKQ-KDTTPKSITEINGIGKVTAEKLENA 707
294495850 629 HILVTDKTCDKHSLYHIKVKGQKKRAW----DLGCPYCNYLEWKEEQKKEKAATPR---PEKISDIPGIGKVTEEKLNSA 701
21229178  711 GITSVEALAEADPVELAKTIKTSVKKIKNWQTSCN 745
20091341  711 GITSVEALAEADPIELAKTIKTSVKKVKTWQISCN 745
73669895  711 GITSVEALAEADPVELAKAIKTSVKRVKSWQVSCN 745
108804786     -----------------------------------    
91772172  709 EINTIDELRQANAIELSKATSLPAGKIMKWQELVT 743
116753908 692 GIKTLEALVSTDPASISESTGISIKKIISWQESAR 726
147919417 701 DENTAEPKKPAARKAAPKKKVIEKAPEA------- 728
282165112 700 PLVKS------------------------------ 704
298674647 708 GVSSVEELANADAVELSKQTNLSVKKIKNWQEYVA 742
294495850 702 GISTVDELENSDANEISKTTNIPLGKIIRWQEAVA 736
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