Conserved Protein Domain Family
dnaE
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PRK06826: dnaE 
DNA polymerase III DnaE; Reviewed
Links
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Statistics
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PSSM-Id: 235868
Aligned: 50 rows
Threshold Bit Score: 1904.62
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
51891797    29 PEFVHLHLHTEYSLLDGANRIEPLARRAAELGMRAMAMTDHGVLFGVLPFYKAMRNHGVKPIIGCELYVAPGSRHVKSG- 107 
114567554    3 GSFVHLHNHSEYSLLDGACRIKDLVNRAVELEMPAVAITDHGVLYGVIDFYREARKRGIKPLIGCELYVAPRSRLDKEAr 82  
258514118    2 PSFVHLHVHTEYSLLDGAARIKEVVKKAKSLGMSALAITDHGVMFGVVDFFKACKKEGIKPILGCEVYVAPRSRHDRTPr 81  
222529253    1 MSFVHLHLHTEYSLLDGACRIDRLFERVKDLNMNAVGITDHGAMYGVIDFYKTAKENGIKPIIGCEVYLAPRTRFDKEPn 80  
146296832    1 MSFVHLHVHTEYSLLDGAVRIESLFERVRQLNMHSIAITDHGAMYGVVDFYKAAKENGIKPIIGCEVYLAPRSRFDKEPn 80  
302871937    1 MSFVHLHLHTEYSLLDGACRIDRLFERVKELNMNAVAITDHGAMYGVIDFYKAAKENGIKPIIGCEVYLAPRTRFDKEPn 80  
83590706     2 KSFVHLHVHSEYSLLDGAGRIKDLVRAAGEMGMPALALTDHGVMYGAVEFYKAAREQGIKPIIGCEVYVAPRSRHDREPh 81  
297617868    2 QGFVHLHTHSEYSLLDGAVRVSSLVKRAKELGMPALAITDHGVLYGVIDFYKQARKAGIKPIIGCEVYVAPRHRFDRTPk 81  
78044608     1 MSFVHLHTHSCYSLLDGAGKIKDLVGRAVELKMPALALTDHGNLFGVIEFYKEAKAQGIKPILGVEVYVAPRTRFDKTPk 80  
147678555   13 NLFVHLHLHSEYSLLDGAARINDAVKRASEMQMPALAITDHGVMFGTVDFYKACKKAGIKPVLGCEVYVAPRSMDDRTPk 92  

51891797   108 -GEKPYHLTVLAENYTGYKNLVKLVSAGYTEGFYYKPRVDLELLNTYREGLIVLSGCLAGEVAQKFLAGQPEEARRAIGR 186 
114567554   83 iDDNLYHLTLLCKNELGYRNLVQLVSRAFLEGFYYKPRVDQELLEKYHEGLIALSGCVVGEIPRLLQNGDYRGAREKALY 162 
258514118   82 vDDNLYHLVLLAKNETGYRNLLNLVSISFTEGFYYKPRVDKEVLAMYSEGLIALSGCIAGEVAEYILKDLPEQARAAAAE 161 
222529253   81 iDNDIHHLVLLAMDNDGYRNLSKIVSIGFVEGFYYKPRVDREVLSKYSKGLIALTSCLAGEIPKLILREQKEKLYDAINF 160 
146296832   81 iDNDIHHLVLLAIDNEGYKNLSKIVSIGFVEGFYYKPRVDREILSKYSKGLIALTSCLAGEIPKFILRDQKEKLMDAIGF 160 
302871937   81 iDNDIHHLVLLAIDNDGYRNLSKIVSIGFVEGFYYKPRVDREVLSKYSKGLVALTSCLAGEIPKLILREQKEKLYDAISF 160 
83590706    82 rDDYQYHLVLLATDATGYRNLTALVSAAFLEGFYYKPRVDRELLSRHSQGLIALSACLAGEVPAHLLKNREDAAYEAATW 161 
297617868   82 vDDALYHLTLLCENQDGYRNLVQMVSKAFLEGFYYKPRVDKELLEQHGRGLIALSGCIAGEVPELLLAGNYEEARAVAGY 161 
78044608    81 iDDQLTHLVLLAKDRTGYQNLLRLVSRSYTEGYYYKPRVDKQLLAENSQGLIALSSCLAGEIPELILSGQREKAREVAGI 160 
147678555   93 iDDNLSHLVLLAENEEGYRNLLNLVSMAFIRGFYYKPRVDKELLSEHSRGLIALSGCIAGEVSARILAGENEKARQAAGD 172 

51891797   187 YREIFGPDHYFLELQDLGLPEQQGLNRFLL----EQGLPVVATNDAHYLRPQDARTQDVLICIGTNKTIDDPNRMRMGTS 262 
114567554  163 YQELFGSGNFYLELQDHGLQEEKASLPGLLrlsrEDSIPLAASNDCHYLRKKDAQVHDVLLCIQTGSVVNDEKRLRFSGS 242 
258514118  162 YLKIFGEDNYYLEIQDHSFPEQKKANRELVkiseELNIPLVATNDVHYVAKENAEMQDVLLCIQTGKTVDDPKRMKFQSQ 241 
222529253  161 YKEVF-GENFYFELQYHYIDEQRFVNNELMrlskKYQIPLVATNDVHYLRREDRNLHDILLCIQTGKTISDSNRMEFPTD 239 
146296832  161 YKDVF-GCNFYFELQYHGIDEQRFVNSELIrlskKYQIPVVATNDVHYLKREDREIHDILLCIQTGKTIHDSNRMEFPTS 239 
302871937  161 YKEVF-GENFYFELQYHYIDEQRFVNNELMrlskKYQIPLVATNDVHYLKKEDRNLHDILLCIQTGKTINDSDRMEFPTD 239 
83590706   162 LREVFGPENFYLELQDQGLPEQRQLNRRLVdlaaRLKIPLVATNDVHYIRQDQARAHDVLLCIQTGKTLDDPNRLRFPTA 241 
297617868  162 FREVFGENNFFLEVQDHGLSEQRVVNEAMChlsrELDVPLVATNDVHYLNRDDAFIHDVLLCIQTGKVLTDESRMRFPCP 241 
78044608   161 YRDIFGKENFYLELQYHGISEQKVVNRELIalskQLNIPLVATNDVHYILKEHAKTHDVLLAIQTGKSINDPGRMKFPTE 240 
147678555  173 YRDIFGPENFFLELQDHGFAEQRKVNREMLkihkEMNIPLVVTNDVHYVRRGDAETQDVLLAIQTGKSVDDPGRMKFQSE 252 

51891797   263 ELYVKSAEEMYWRFGHVPGALENSLAIAERCNVELPLGQIHLPHYALPPGY-DAPGYLRKLCYERIGPRYggRPPE--GA 339 
114567554  243 EFYMKSREEMAALFPDYPEALENTLKIAGECNLDFTFGEYHLPVFELPPGH-SAESFLSEMVHEKFRRKY--PDAQe-KI 318 
258514118  242 EFYLKSPEEMAELFPELPQALQNTVSIADKCEISMEFGQLHLPFYQVPEGH-TVESYLRELCEKGLLDRY--GAAPeeSV 318 
222529253  240 EFYLKSPEEMQQLFGYIPEALKNTLEIAEKCNVEFEFGKINLPKFQLPEGKsDAFEYLKELALEGFKKRY--KNDDk-AA 316 
146296832  240 EFYLKSAQEMEEVFGYIPESLKNTLEIAEKCNVEFEFGKINLPKFQLPEGKsDAFEYLKELAFAGFEKRY--SKENk-AA 316 
302871937  240 EFYLKSSEEMHQLFGYIPEALKNTLEIAEKCNVEFEFGKINLPKFQLPEGKnDSFEYLKELALEGFKKRY--SKNNk-TA 316 
83590706   242 QFYLKSPAEMDNLFREVPSALANTLAIAERCHFDFTFGRLHLPAYQVPAGE-DAASYLRRLSYEGLKRRYphDDg---TA 317 
297617868  242 EFYFKSGEEMSSLFAHIPEAVTNTVTIAERCSVDFGFDSFCLPEFPLPEGA-TAESYLEDLAWKKLRERF--AHPGt-KV 317 
78044608   241 EFYLKTPYEMELIFGELPDALKNTLNIAEQCNLEFEFGRYLLPDFPVPEGK-TPAQYLKELCFQGLYKRY--PNPGe-EV 316 
147678555  253 ELYLKSPEEMNLLFGELSGALRNTVEIAGRCNVEIEFGKYYLPHYPVPEGY-DADTYLAELCYQGARRIY--GELSd-GV 328 

51891797   340 MERLEHELNVIISMGFAGYFLIVWDFVEFARSRGIPVGPGRGSGASSLVAYVLGITDVDPLRYGLLFERFLNPERVDMPD 419 
114567554  319 IERLEYELRVINEMGFAAYFLIVQDLVNWSRQNGIPVGPGRGSAAGSLVSYVLDITTIDPLRYDLLFERFLNPERVSMPD 398 
258514118  319 RQRMEFELSVIEQMGYSAYFLIVWDFIDYARQNGVPVGPGRGSAAGSLVSYVLGITNLDPLKYDLLFERFLNPERVSMPD 398 
222529253  317 YDRLMMELQVIKDMGFVEYFLIVQDFINYAKQNNIMVGPGRGSAAGSIVAYCLGITNVDPIKYDLLFERFLNPERVSMPD 396 
146296832  317 YDRLLMELNVIKDMGFTEYFLIVHDFINYAKQNNIMVGPGRGSAAGSIVAYCLGITNVDPIKYNLLFERFLNPERVSMPD 396 
302871937  317 YDRLMMELQVIKDMGFVEYFLIVQDFINYAKQNNIMVGPGRGSAAGSVVAYCLGITNVDPIKYDLLFERFLNPERVSMPD 396 
83590706   318 RQRLEYELGIIEQMGYPGYFLIVWDMVNFARRRGIPVGPGRGSAAGSLVAYCLGITSIDPLRYNLLFERFLNPERVSMPD 397 
297617868  318 IDRLRLELDVINRMGFAGYFLIVQDLVHWAKNRGIRVGPGRGSAAGSLVSYVLGITDINPLEYGLLFERFLNPERITMPD 397 
78044608   317 KTRLLHELKIIEQMGFSGYFLIVWDFIRYAREKGIMVGPGRGSAAGSLVAYTLEITDIDPLKYGLLFERFLNPERVSMPD 396 
147678555  329 KKRLEYELGVIKQMGYSAYFLIVWDFIHYARQNGIPVGPGRGSAAGSLVAYSLGITSIDPLKYGLLFERFLNPERVSMPD 408 

51891797   420 FDIDFCYERRGEVIEYVHNKYGAECVAQVITFNTMAARAAVRDVGRALGMSYGEVDRVAKLLP--WGQSLDAALEKTEEL 497 
114567554  399 IDIDFCFEKRDRVIDYIISKYGADRVAQIITFGTMAARAAIRDVGRALDVPYGQVDRIAKMVPaeLGVSLERALEISPDL 478 
258514118  399 IDIDICYERRNKVIEYVVRKYGAERVAQIATFGTMAAKGAIRDVGRALAMSYGEVDRVAKLVPaeLHMTIEKALSENQDL 478 
222529253  397 IDIDFCYQRRQEVIDYVTRKYGEDRVSQIITFGTMAARASIRDVGRVLGVPYSQVDEIAKMIPfsPGMTIDKALEINHDL 476 
146296832  397 IDIDFCYQRRQEVIDYVTNKYGKDKVSQIITFGTMAARASIRDVGRVLGVPYAQVDEIAKMVPfsPGMTIDKALEVNHDL 476 
302871937  397 IDIDFCYQRRQEVIDYVTRKYGEDRVSQIITFGTMAARASIRDVGRVLGIPYSQVDEIAKMIPfsPGMTIDKALEINHEL 476 
83590706   398 IDMDFCFERRDEVIQYVLEKYGRDHVAQIITFGTMAARAAVRDVGRVLGLPLGEVDRIAKMVPmeLGITLERALATSPDL 477 
297617868  398 IDIDFCFEKRDQVINYVIEKYGSDRVAQIITFGTMAARAAIRDVGRVLEYPYSEVDRIAKMVPaeLGISLDRALEVSGDL 477 
78044608   397 IDVDFCFERRQEVIDYLYQKYGEDRVAQIITFGTMAAKAAVRDVGRALDWPYSEVDKIAKLIPnvLGITLEEAIETTPEL 476 
147678555  409 IDVDFCFERRGEIIDYVVRRYGADRVAQIITFGTMAARAAIRDVGRALNMPYGEVDRVAKLVPmeLHMTIEKALNESPEL 488 

51891797   498 RTLYEEREEIRTLIDTARAVEGMPRNPSVHAAGVVITADPLVEHVPLYKmGDDSIVTQFDMDQLKEIGLLKMDFLGLRTL 577 
114567554  479 FTAYQSDYNTRNILDIAQAIEGMPRHASIHAAGVVIGRQSLSEILPLQKtPEGHVLTQFTKETVEDIGLLKMDILGLRTL 558 
258514118  479 LEAYNNEPEVRRLIDTAKGLEGMPRHASTHAAGVVITKQPLTHYLPLYKsTDGPVTTQFAKEPVEELGLLKMDLLGLRTL 558 
222529253  477 KKIYEQNDTVRRIIDTARNLEGMPRHASVHAAGVVISSCPITDLVPLAR-TDDAIVTQFPMTTLEELGLLKMDFLGLRTL 555 
146296832  477 KKIYEQNETVKRIIDTARSIEGMPRHTSVHAAGVVISSCPITDLVPLAR-TEDAIVTQFPMTTLEELGLLKMDFLGLRTL 555 
302871937  477 KRIYERNDTVRKIIDTARNLEGMPRHASVHAAGVVISNSPITDLVPLAR-TDDAIVTQFPMTTLEELGLLKMDFLGLRTL 555 
83590706   478 KESYEGNREVRELLDTARAIEGMPRHASIHAAGIVITREPLIHYLPLQK-TGDAVTTQYPMQAVEELGLLKMDLLGLRTL 556 
297617868  478 AEAYKNDFRVRRLVDTARALEGFPRHASVHAAGVVIGRESLSRVLPLQRtADGHVVTQFTKETVEEIGLLKMDILGLRTL 557 
78044608   477 KTLYQNNPKVRELLDLARQIEGMPRHASVHAAGLVIAPEEIDKHIPLFKtSEGVVTTQFEKDTVEELGLLKIDLLGLRTL 556 
147678555  489 RELYDQRPEVRKLIDTAAALEGMPRHASTHAAGVVITPEPLTNYLPLYKaTDGPVTTQFAMGTVEELGLLKMDLLGLRTL 568 

51891797   578 TVIDHAVKFVRQYQpD-FDIERIPMDDPETYAMIARGETLGLFQIEAGWVADVLRQMKPTRFEDIIATISLCRPGPMEH- 655 
114567554  559 TVIDRALEIIRKTRdEdIDISSIPLDDEAVYKLLSAGDTAGVFQLESDGLRRLLCEMKPDRFEDIIAVIALYRPGPLGSg 638 
258514118  559 TVIADAVAEVNKRAgSpLDIDKITLEDKNTFDLLSRGEGIGVFQLESSGMRAILRDLKPEVFEDIVALVALYRPGPLGSg 638 
222529253  556 TVIQNTLELVKKNRgIeIDLDRIDYNDKNVYEFISEGNTNGVFQLESSGMKQFMKELKPENLEDIIAGISLFRPGPMDQ- 634 
146296832  556 TVIQNTLELIKKHRkIeIDLDKIDYNDRSVYQFISEGNTNGVFQLESSGMKQFMKELKPENLEDIIAGISLFRPGPMDQ- 634 
302871937  556 TVIQNTLELVKKNRgIeIDLDRIDYNDKNVYEFISEGNTNGVFQLESSGMKQFMKELKPENLEDIIAGISLFRPGPMDQ- 634 
83590706   557 TVIGHAREAIRRNHgReLDLESLPLDDRPTYQLLASGETSGIFQLESSGMRAILKELKPERFEDIIALVALYRPGPLGSg 636 
297617868  558 TVIDRCLDIIRKTRgYeIDIDHISLDDPDTYRLLSEGDTVGVFQLESEGLRRLLQEVRPSSFEDLIAIIALYRPGPLGSg 637 
78044608   557 TVIEKALDFIKKQTgKeINLKDIPLDDEKTYKLLGEGDTVGVFQLESQGMRQILKELKPTSIEDLIALVALYRPGPLGSg 636 
147678555  569 TVISDALRLIKESTgEeLDIERIPVDDQKTYQMLARGETAGVFQLESSGMRSILRDLRPEVFEDIVALVALYRPGPLGSg 648 

51891797   656 -IPDYIAGKQNPAGVKYLHPDLEPILSETYGVMVYQEQIIQIAHLLAGLSLGQADLLRRAIAKKKREDMEKYGRLFMEal 734 
114567554  639 mVEDFINRKNGRQEIEYIDPLLEDILKETYGVILYQEQVMRVASELADFTMGEADVLRRAMGKKKAEELMAQRDKFiaga 718 
258514118  639 mVDDFIKNKHGLQKVSYLHPILEPILKDTYGVILYQEQVMRISSDLAGFSLGEADLLRRAMGKKKPEVIAGLRSQFmega 718 
222529253  635 -IPVYIQNKNNREKIEYLHPSLEPILNVTYGCIVYQEQVMQIFRTLAGYSLGRADLVRRAMAKKKADILMEEKDRFIEga 713 
146296832  635 -IPVYIQNKNNKEKIEYLHPKLEPILNVTYGCIVYQEQVMQIFRELAGYSLGRADLVRRAMAKKKADILMEERDRFiega 713 
302871937  635 -IPVYIQNKNNREKIEYLHPSLEPILNVTYGCIVYQEQVMQIFRTLAGYSLGRADLVRRAMAKKKADILMEEKDRFiega 713 
83590706   637 mVEDFIKRKHGVTPISYLHPALEPILKDTYGVILYQEQVMRIASELAGFTLGQADLLRRAMGKKKPEVLAAQRDRFlaga 716 
297617868  638 mVEDFVNRKHGRQPIEYLHPKLEPILRETYGVILYQEQVMRIASELADFSMGEADVLRRAMGKKKPDELAAQRNKFvega 717 
78044608   637 mVEDFINRRHGRVPVEYPHPDLEPILRETYGVIVYQEQVMLIASVLAGFSLGEADLLRRAMGKKKPEIIAALKNDFIErs 716 
147678555  649 mVDDFIKNKHGFKKTKYLHPRLEPILKDTYGVILYQEQVMRIASDLAGFSLGEADLLRRAMGKKKPEIIAGLRSQFiega 728 

51891797   735 eQRGYSHEVATALYDQMIRFANYGFNKCHATPYAKVAYQTAYLKRHHPVAFMAALMNSVMGQEAKLALYIEECRRLGIQV 814 
114567554  719 aRNGIGLATASHLFDLMESFAGYGFNKSHSAAYALISYQTAYLKAHYPVEYLCAFLSSVIDNQDKVVSYIKECRRLGIKV 798 
258514118  719 aKKDVDPEVAGKVFDLMEFFAGYGFNKSHSAAYALVSYQTAYLKANYPAEFMAALLTSVRDNSDKVAVYIEECRRMGIVV 798 
222529253  714 mANGIDKETAEKIFAIIEDFASYAFNKSHAAAYAILAYQTAYLKKYYTIEFMASLITSVMNSNEKVGMYIEECRKFGISI 793 
146296832  714 vANGVDRQTAEKIFEIIEDFASYAFNKSHAAAYAILAYQTAYLKKYFTIEFMTSLITSVMNSNEKVGMYIEECRRFGISI 793 
302871937  714 vANGVKKETAERIFAIIEDFASYAFNKSHAAAYAILAYQTAYLKKYYTIEFMTSLITSVMNSNEKVGMYIEECRKFGITI 793 
83590706   717 eAKAIPRDVAQKIFELMEYFAGYGFNASHSAAYALVAYQTAYLKAHYPAELMGALLSSVAEHLDKMEPYLAECQRLGIAV 796 
297617868  718 yRNGIDRETASSLFELMEHFAGYGFNKSHSAAYALVSYQTAYLKAHYPVEYMCAFLTSVIDNQDRVVYYLKECRRMGMDI 797 
78044608   717 vARGYPREKAEEIFNLIEYFAGYGFNKSHSAAYAFVAYYTAWLKANFPVAFLAALLISVKDNLDKVTVYAEDCQRRGIKV 796 
147678555  729 aRNGVDGETAGQIFDLMEYFAGYGFNKSHSAAYALVSYQTAYLKANYPLQFMAALLTSVKDNTDKVAAYIEECRRLGIEV 808 

51891797   815 LPPDVNTSFARFVPDGRTIRFGLGAVKNIGWNAVDAIVAAREEGGPFTSLRDLCERVDLRPLNRRALESLIMAGAFDRVA 894 
114567554  799 LPPDINESYENFSVARDAIRFGLGAIKNVGQNAVKNIVEARKQ-GFYTSLFDFCRRVDLGQLNKRMLENLILAGCFDSLG 877 
258514118  799 LPPDVNESRDGFTVVGDKIRFGLAAMKNVGLAAVYSIISMREQGGPFKNYADFCNRLDTRVVNRRVLESLIKGGAFDSLG 878 
222529253  794 LPPDINKSSYDFTIEGNSIRFGLRAIKSLGENVIAHILKEREKKGEFKDLYDFIMRVDTNTVNKRIIENLIRSGAFDFTG 873 
146296832  794 LPPDINKSSYDFTIEGNSIRFGLRAIKSLGENVISHILKEREQNGEFKDLYDFVMRVDTNTVNKRIIENLIKSGAFDFTK 873 
302871937  794 LPPDINKSSYDFTIEGNSIRFGLRAIKSLGENVIAHILKEREEKGEFKDLYDFIMRVDTNTVNKRIIENLIRSGAFDFTR 873 
83590706   797 LPPDVNESGVDFTVTGRQIRFGLAAVKNAGRAAALAIIAAREAGGPFTSLLDFCRRVDSRQANKRVVESLIRCGAFNSIN 876 
297617868  798 LPPDINESFENFTVAGGRIRFGLGAIKNVGINAVRSIIEARKE-GRFSSLLEFCLRVDLRQLNKRVMENLILAGAFDSLG 876 
78044608   797 LPPDINLSEVDFTISGQEIRFGLAAVKNVGEAAAAKIIEERQK-GPFRDFNDFLHRIDKKTVNKRVIESLIKAGAFASFG 875 
147678555  809 LPPDVNESRESFTVAGNKIRFGLAAVKNVGMGAVDSIIRAREKDGPFSDYADFCRRLDTRVVNKRVLESLIKCGAFDSLG 888 

51891797   895 ppggrpARRSQMLEALDKILDDAQKLQRHRQAGQISLFDLGVAgpgtagEEP----------LPDIPEFPPQRLLAMEKE 964 
114567554  878 ------FSRKGALSIMEECVNISLAIKQNECSQQGSLFGDememv-------------eepiIKLKGEYESRERLLKEKE 938 
258514118  879 ------HRRAQLMAVVDTGLSIAQQAQRDRNSGQMSLFEFLEE------EEEynl----sfvLPDIAEYLYSEMLALEKE 942 
222529253  874 ------LNRNSLLASVEDIL--AIKQTKKKNANQFSFFEI---------SGNene----sfvYKNMPQPTAQELMKMEKD 932 
146296832  874 ------INRNSLLASVEDIL--TIKQSQKKNANQITFFEI---------SDDqtk----ifsYKDLPEPTTEELLQMEKD 932 
302871937  874 ------INRNSLLASVEDIL--VLKQAKKKNANQFSFFEI---------SGNene----sfeYKSLPQPTAQELMKMEKD 932 
83590706   877 ------PNRRQLLAGLDECLEVAARRQEDRRSGQVSLMDLVPEe----vNDPp---------LPQVTDFSRADILAMEKE 937 
297617868  877 ------LKRKEALSLLDECLALAVEVRAAMDSAQPSLF-----------VDDaaatvvqdpvPRSKGEFSVQEKLKKEKE 939 
78044608   876 ------FNRKTLLNNLDDALEFYSKKSNGV---QLTLGDFLPE------ADRynl--------rleEEFSKLELLRMEKE 932 
147678555  889 ------YRRAQLMAAVDSGLALAQQSQRERENGQLSLLDFFGG------STDsvs-----isFPEVGEYPEDELLAMEKE 951 

51891797   965 VLGFYVSGHPLRQYQAALAAHGCLPVAALPE-----QRDGARVAVGGMVAGLKQVTTRSGANMAFLTLEDQTGQVEVVVF 1039
114567554  939 VLGFFVSESPLDEFRSLLPLISTHCLEDINL-----WEEESYVRVAGIVVNLSRRVSRKGESYARFVLEDLGGRIEVLVF 1013
258514118  943 SLGLYISGHPLAEYREVLRQNDTVNAGELPD-----FTEGETVALGGLIINYKQITTKKGDAMAFVNLEDLTGVVEVVIF 1017
222529253  933 TIGVYISSHPLEKYTEEISKYNITPLSEIsamseedeyKFEQILVCGILKEVKVKLTKNNLTMAFAKLEDLTDSVEVLFF 1012
146296832  933 TIGIYISGHPLEKYGDLISKYNVVSLAELsnmteddeyKYQQILVCGILKEVKIKLTKNNQTMAFAKIEDLTDTLEVLFF 1012
302871937  933 TIGIYISSHPLERYTEEISRYNVTPLSEIstmseedeyKFEQILVCGILKEVKVKLTKSNQTMAFAKLEDLTDSVEILFF 1012
83590706   938 LLGFYLSGHPLEPYAPVLKKLTSHSLADLAE-----IADGSQVTIGGLVSGLRRLVTRKGDPMAVLTLEDFSGQVEAVLF 1012
297617868  940 VLGFYVSQNPLEEYREVIPYLMSHEISELSK-----LDEGQVVRIVATVTAMKRSRSKKGEPWARLVLEDFTGKVEAVVF 1014
78044608   933 SLGLYLTGHPLAGLRSFIQKHCNLK------------ENKEKIYYPAILAEIKRTVTRRGEPMAFALLEGLNQTVEAVIF 1000
147678555  952 TLGLYISGHPLSRYREALNRLTTVKTVEITD-----LPDNSEVVLGGLITDVKKINTRRGEVMAFLTLEDLTGTVEVVVF 1026

51891797  1040 PRVLQACARVLREEQPLLVRGRLQVQEDE-VKLLADEVSLLRddekprrpepperievgaaqprglepgpgrmsgdmgsd 1118
114567554 1014 PSAYRKNGDRLEADRAVIVEGYFD-RREEqPKIALRKTGPIP-------------------------------------- 1054
258514118 1018 PRIFKQYRQLLQPDRVVLVKGRVN-QAGEeIKIIAEEVSSLVk------------------------------------- 1059
222529253 1013 PNVYEKYSHLIKEDMVVIMEAKATFREDEgVKVIAQKVDRLGekhqegq------------------------------- 1061
146296832 1013 PSVYEKYSHLIKENTIALIEAKATFREDEgVKIVAQKIDRLGekvqt--------------------------------- 1059
302871937 1013 PSVYEKYSHLIKEDMIVLIEAKATFREDEgVKVIAKKVDRLGsdrpe--------------------------------- 1059
83590706  1013 PRMYSQVRSWLAPDRAVLVQGQVD-KQEEgVQVLANLVRPLAp------------------------------------- 1054
297617868 1015 PAVYRQHYRQIKLDTALVIEGKV-IHRDDsVEVAVNQVYPVS-------------------------------------- 1055
78044608  1001 PDCWLTYRDLLQEENILWFYGAVE-EDEEgLKMIVERVYELDm------------------------------------- 1042
147678555 1027 PRTYTQNRLALRVDEVVLVKGKTS-GGGEeTKIIGEEISTVEs------------------------------------- 1068

51891797  1119 phatvrgpgaapepaaargKQaapasarqpgpppasepapgparATAaeaaretplgpqpqfVYLRVPARDENSPMMRRV 1198
114567554 1055 -------------------ES-----------------------LRE---------------MHLRLAGNGDGEMDRNKL 1077
258514118 1060 -------------------TT-----------------------QGD---------------LYLQFIKR-DMQT-VKQV 1080
222529253 1062 --------------------------------------------------------gsgekaIAIRVSDDTILKS--KKF 1083
146296832 1060 --------------lssqrNS-----------------------NKA---------------IAIKTDEDSILKS--KKF 1085
302871937 1060 ---------------etqnSR-----------------------EKA---------------IAIRVSDDTILKS--KKF 1084
83590706  1055 -------------------EAgggdrtlpppagthgtlpearqgGGR---------------LYLKLSSEGQLTA----L 1096
297617868 1056 -------------------HE-----------------------LKE---------------LHIQVSNAAGTGNSKSEL 1078
78044608  1043 -------------------SN-----------------------ALE---------------VYLKV----SPGN-IPLV 1060
147678555 1069 -------------------CL-----------------------GGE---------------LHIKIDSV-SSPL-LDQI 1089

51891797  1199 EQVLRAHPGPTRVRIKMEPEGKWIEVHEHLRVTVTPSLVNALARIVGE-QSVVVR 1252
114567554 1078 VKLLQKYPGDIEVFLH-LPGRRLLVLNEKFNVSPSQDLKQELAAVYGP-QNVWFN 1130
258514118 1081 QLILQTYPGNNHVYLYFPQEKKLAKTSENYWVNLDSEVVKELEQVLGV-SNVRIK 1134
222529253 1084 LAFIKFFSGKSKIVLY--YNQKRLISKSNLCIEINPTVIEQLKEWFGD-ENVWIE 1135
146296832 1086 TSFVRFFTGSSKIILY--YKQKRLVSKSNMGIDINPTVIQQLKEWFGE-ENVWLE 1137
302871937 1085 LAFLKFFAGKSKIVLY--YNQKRLISKSSLCIEINPTVIEQLKEWFGE-ENVWIE 1136
83590706  1097 RDTLAAHPGPCQVYLYLADSRRTIALHRRYWIEPVPELMASLAGLLGGyDKIKLV 1151
297617868 1079 VRILGGYSGEIPVYLR-LSANKVIRLDKNLWVQPSLALKQQLSSLYGR-GNVWFR 1131
78044608  1061 QGILRKYPGPAPVYLY-PGGKKLIKLSQEYWIDLKSPVLWEIKKLLGD-ENVKTK 1113
147678555 1090 QLILSSFKGESPVFLHFEKERRIIKAGENFWVDLSGPVVSRLEDLLGH-ARVKIK 1143
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