Conserved Protein Domain Family
PLN03237
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PLN03237: PLN03237 
DNA topoisomerase 2; Provisional
Links
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Statistics
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PSSM-Id: 215641
Aligned: 9 rows
Threshold Bit Score: 2272.85
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
225450069    3 VDNKLPLQSS------------------------NNANMPAKP-------AGKTIEETYQKKSQLEHILLRPDTYIGSIE 51  
186510360    1 MATKLPLQNS------------------------NAANVAKAPaksraaaGGKTIEEMYQKKSQLEHILLRPDTYIGSIE 56  
15229538     1 MATKLPLQNS------------------------NAANVAKAPaksraaaGGKTIEEMYQKKSQLEHILLRPDTYIGSIE 56  
255076711    4 VAEIVAINENvaaapkakka----paakkpkaplGEKDVNAAKpasssssDGKAIEDIYQKKTQLEHILLRPDTYVGSCE 79  
224055129    1 ------------------------------------------------mnQGKTIEETYQKKSQLEHILLRPDTYIGSIE 32  
224106109    4 ETKKIPLSTSdsl----------------------------------nmnQEKTIEETYQKKSQLEHILLRPDTYIGSIE 49  
242062820    1 --MAGPLHSS------------------------SGHNAAAGG-------GGKTIEEMYQKKTQLEHILLRPDTYIGSVE 47  
303276424    1 MSEIVEMGENapatkkapaakkaagpakakplgdSSNAVVAPPtasatssPGKSIEDIYQKKTQLEHILLRPDTYVGSCE 80  
297831176    1 MATKLPLQNS------------------------NNANVAKAPrg---aaAGKTIEEMYQKKSQLEHILLRPDTYIGSIE 53  

225450069   52 KHTQALWVF--ENNEMVHRSVSYVPGLYKIFDEILVNAADNKQRDPSMDSVKVVIDVEKNCISVYNNGDGVPVEIHQEEG 129 
186510360   57 KHTQTLWVY--EKDEMVQRPVTYVPGLYKIFDEILVNAADNKQRDAKMDSVQVVIDVEQNLISVCNSGAGVPVEIHQEEG 134 
15229538    57 KHTQTLWVY--EKDEMVQRPVTYVPGLYKIFDEILVNAADNKQRDAKMDSVQVVIDVEQNLISVCNSGAGVPVEIHQEEG 134 
255076711   80 KTEEKAWVYckDTNKLVQRQMSFVPGLYKIFDEILVNATDNKVRDPSMVTLRVDIDQEAGCIRVYNDGNGIPVEMHKEEG 159 
224055129   33 KHAQTLWVY--EGDKIVHRPVTYVPGLYKIFDEILVNAADNKQRDPKMDSLKVVIDGENNLVSVYNNGDGVPVEIHKEEG 110 
224106109   50 KHAQILWVF--ENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPKMDSLKVVIDVENNLVSVYNNGDGVPVDIHKEEG 127 
242062820   48 KHTQPLWVF--EDGAMVNRSVTYVPGLYKIFDEILVNAADNKQRDPKMDALRVQIDVDGCCISVYNNGDGIPVEIHQEER 125 
303276424   81 KTEALTWVYdkETNKLVQRNMSFVPGLYKIFDEILVNATDNKVRDPTMVTLRVDIDSAEGTIKVFNDGNGIPVEMHKEEG 160 
297831176   54 KHTQTLWVY--EKDEMVNRSVTYVPGLYKIFDEILVNAADNKQRDPSMDSVQVVIDVEQNLISVCNSGAGVPVEIHQEEG 131 

225450069  130 VYVPEMIFGHLLTSSNYDDDVKKTTGGRNGYGAKLTNIFSTEFVIETADGRRQKKYKQVFSNNMGKKSEPVITKCKEREN 209 
186510360  135 IYVPEMIFGHLLTSSNYDDNVKKTTGGRNGYGAKLTNIFSTEFIIETADGKRLKKYKQVFENNMGKKSEPVITKCNKSEN 214 
15229538   135 IYVPEMIFGHLLTSSNYDDNVKKTTGGRNGYGAKLTNIFSTEFIIETADGKRLKKYKQVFENNMGKKSEPVITKCNKSEN 214 
255076711  160 VYVPELIFGHLLTSSNYNDNEKKVTGGRNGYGAKLANIFSTEFVVETCDGSRERRYRQVFKNNMGEKCEPVVTKCKPTDN 239 
224055129  111 VYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSNNMGKKSEPMITKCKEGEN 190 
224106109  128 VYVPELIFGHLLTSSNYDDTMKKTTGGRNGYGAKLTNIFSTEFVIETADGKRKKKYKQVFSNNMGKRSEPIITKCKESEN 207 
242062820  126 VYVPEMIFGHLLTSSNYNDNEKKTTGGRNGYGAKLTNIFSTEFVIETADGRRQKKYKQVFSENMGKKSEPQITKCKQGEN 205 
303276424  161 VYVPELIFGHLLTSSNYDDNEKKVTGGRNGYGAKLANIFSTEFIIETCDGARERRYRQVFKNNMGEKCEPVVTKCKKSDN 240 
297831176  132 IYVPEMIFGHLLTSSNYDDNVKKTTGGRNGYGAKLTNIFSTEFIIETADGKRLKKYKQVFENNMGKKSEPVITKCNKSEN 211 

225450069  210 WTKVSFKPDLAKFNMTHLEDDVVALMKKRVVDIAGCLGKTVKVELNGQRIPVKSFNDYVNLYLQSAAKSRP--ESLPRIA 287 
186510360  215 WTKVTFKPDLKKFNMTELEDDVVALMSKRVFDIAGCLGKSVKVELNGKQIPVKSFTDYVDLYLSAANKSRTe-DPLPRLT 293 
15229538   215 WTKVTFKPDLKKFNMTELEDDVVALMSKRVFDIAGCLGKSVKVELNGKQIPVKSFTDYVDLYLSAANKSRTe-DPLPRLT 293 
255076711  240 WTCITFKPDLAKFNMTELEDDTVALMCKRVYDAAGNIGKNTKVFLNGERLKVKGFSDYVDLYLEGR-------ENAPKVY 312 
224055129  191 WTKVTFKADLAKFSMTHLEEDVVALMKKRVVDIAGCLGKTVKVELNGSRVPVKSFQDYVYMYLNSASEPGSe-RPKRFFY 269 
224106109  208 WTKVTFKPDLAKFSMTHLEEDVVALMKKRVVDMAGCLGKTVKVELNGSRVPVKSFQDYVNMYLNSAAESGS--ERPKCFY 285 
242062820  206 WTRVTFKPDLAKFNMAHLEEDVVALMRKRVVDMAGTLGKTVKVELDGQRVPIKSFSDYVNLYMKSANCDRP--DNFKTIY 283 
303276424  241 WTCITFKPDLSKFNMTHLEDDTVALMCKRVYDAAGNIGKNTKIFLNGDRLKVKGFSDYVDLYLEGR-------ENAPKVF 313 
297831176  212 WTKVTFKPDLNKFSMTELEDDVVALMSKRVFDIAGCLGKSVKVELNGKQIPVKSFTDYVDLYLKAANKLRAdpDPLPRIT 291 

225450069  288 EKVNERWEICVSLSE-GQFQQVSFVNSIATIKGGTHVDYVTNQIANFVMSIVNKKNKNA-NIKAHTVKNHLWVFVNALID 365 
186510360  294 EKVNDRWEVCVSLSE-GQFQQVSFVNSIATIKGGTHVDYVTSQITNHIVAAVNKKNKNA-NVKAHNVKNHLWVFVNALID 371 
15229538   294 EKVNDRWEVCVSLSE-GQFQQVSFVNSIATIKGGTHVDYVTSQITNHIVAAVNKKNKNA-NVKAHNVKNHLWVFVNALID 371 
255076711  313 EKVNDRWEVCVTISDsGNFQQVSFVNGICTMKGGTHVNQVADEVAGKLLEKIKKKEKSCkNLKAAHVKNHLWVFVNALIE 392 
224055129  270 EKVGERWEVCVSLTE-GQFQQVSFVNSIATIKGGTHVDYVTNQITNYVMNAVNKKHKNS-NIKAHNVKNYLWVFVNCLID 347 
224106109  286 DKVGERWEVCVSLTE-GQFQQASFVNSIATIKGGTHVDYVTNQITNYVMNAVNKKHKNG-NIKAHNVKNYLWVFVNCLID 363 
242062820  284 EN-NDRWEVCVCQSE-GQFQQVSFVNRIATIRGGTHVDYITNQIANHVMTVVNKKNKNA-NMKLHNVKSHLWVFVNALID 360 
303276424  314 EKVNDRWEVCVTISDtGNFQQCSFVNGICTMKGGTHVNAVADDVATKLLEKIKKKEKSCkNLKSTHVKNHLWVFVNALIE 393 
297831176  292 EKVNDRWEVCVSLSE-GQFQQVSFVNSIATIKGGTHVDYVTSQITNYIVGVVNKKNKNA-NVKAHNVKNHLWVFVNALID 369 

225450069  366 NPAFDSQTKETLTIRQSSFGSKCELSQEFLKKVSKSGVVESLLSWADYKQNKDLKKTDGTKRQRLTgITKLEDANDAGGR 445 
186510360  372 NPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVGKSGVVENLLSWADFKQNKDLKKSDGAKTGRVL-VEKLDDAAEAGGK 450 
15229538   372 NPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVGKSGVVENLLSWADFKQNKDLKKSDGAKTGRVL-VEKLDDAAEAGGK 450 
255076711  393 NPAFDSQTKETLNTRASNFGSKYEASDKVIKQMMNSGIVEQILSWASFKQSKEMKKSDGKKATRLTgIPKLDDANDAGGR 472 
224055129  348 NPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVAKSDIVDNLLSWAKFKESKELKKTDGTKTAKVN-VPKLEDANEAGGR 426 
224106109  364 NPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVAKSDIVDNLLSWAKFKENKELKKTDGTKTAKVN-VPKLEDANEAGGR 442 
242062820  361 NPAFDSQTKETLTTRQGSFGSKFELSIDFLKKVEKSSIIENVLSWADFKLSKELKKTDGSKKSRISgIPKLEDANEAGGK 440 
303276424  394 NPAFDSQTKETLNTRAANFGSKFSASDAVIKKMMSSGIVEQILSWASFKQSKELKKNDGAKKTRLTgIPKLDDANDAGGK 473 
297831176  370 NPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVGKSGVVENLLSWADFKKSKDLKKSDGAKTGRVE-VEKLEDAAEAGGK 448 

225450069  446 NSEKCTLILTEGDSAKALAMA---GISVVGRNHYGVFPLRGKLLNVRDAQKKQILENAEIQNIKQILGLQQGKEYDSIKS 522 
186510360  451 NSRLCTLILTEGDSAKSLALA---GRSVLGNNYCGVFPLRGKLLNVREASTTQITNNKEIENLKKILGLKQNMKYENVNS 527 
15229538   451 NSRLCTLILTEGDSAKSLALA---GRSVLGNNYCGVFPLRGKLLNVREASTTQITNNKEIENLKKILGLKQNMKYENVNS 527 
255076711  473 NSEHCTLILTEGDSAKALAVS---GLSVVGRDRYGVFPLRGKLLNVRDASHDQIMNNAEINHIKQILGLRHGTTYESAKS 549 
224055129  427 YSEKCTLILTEGDSAKALAVTgvaGLTQTERSFYGVFPLRGKLLNVREATPKQLKENKEIECIKKILGLQHHKQYSNVKS 506 
224106109  443 YSEKCTLILTEGDSAKALAIAgvaGLSQMERNFYGVFPLRGKLLNVREATSKQLKENKEIESIKKILGLQHDKQYINVKS 522 
242062820  441 DSEKCTLILTEGDSAKALAMS---GIAVVGRDYYGVFPLRGKLLNVREANHKQIMENAEIQNIKQILGLQHGKQYASAKG 517 
303276424  474 NSEHCTLILTEGDSAKALAVS---GLSVVGRDRYGVFPLRGKLLNVRDASHEQIMNNAEISYIKQILGLKHGIQYESAKS 550 
297831176  449 NSRLCTLILTEGDSAKPLALA---GRTVLGENYYGVFPLRGKLLNVREASTTQITNNKEIENIKKILGLKQNMKYDNVSS 525 

225450069  523 LRYGHLMIMTD-------------QDHDGSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHR-NGRVLSFYSMPE 588 
186510360  528 LRYGQMMIMTD-------------QDHDGSHIKGLLINFIHSFWPSLLQVPSFLVEFITPIVKATRKgTKKVLSFYSMPE 594 
15229538   528 LRYGQMMIMTD-------------QDHDGSHIKGLLINFIHSFWPSLLQVPSFLVEFITPIVKATRKgTKKVLSFYSMPE 594 
255076711  550 LRYGHIMIMTD-------------QDHDGSHIKGLLINFLHAHFPSLLKIPGFLVEFITPIIKATK--GKQSKVFYTLPE 614 
224055129  507 LRYGHLMIMTDqakerfanflcfkQDHDGSHIKGLLINFLHSFWPSLLKVPSFLVEFITPIVKATHR-NGTVLSFYSMPE 585 
224106109  523 LRYGHLMIMTD-------------QDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHR-NGTVLSFYSMPE 588 
242062820  518 LRYGHLMIMTD-------------QDHDGSHIKGLLINFIHSFWPSLLKVESFLVEFVTPIIKATR--GKTTISFYTMPE 582 
303276424  551 LRYGHIMIMTD-------------QDHDGSHIKGLLINFLHAHFPSLLKIPGFLVEFITPIIKATK--GKKSEVFYTMPE 615 
297831176  526 LRYGHMMIMTD-------------QDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKAKNKaKKKVLSFYSMPE 592 

225450069  589 YESWKESLGGNAS--GWSIKYYKGLGTSTSKEGKEYFKDLGKHKKDFMWVDEKDGDAIELAFSKKKIEERKNWLRQFQPG 666 
186510360  595 YEEWKESLKGNAT--GWDIKYYKGLGTSTAEEGKEYFSNLGLHKKDFVWEDEQDGEAIELAFSKKKIEARKNWLSSYVPG 672 
15229538   595 YEEWKESLKGNAT--GWDIKYYKGLGTSTAEEGKEYFSNLGLHKKDFVWEDEQDGEAIELAFSKKKIEARKNWLSSYVPG 672 
255076711  615 YDNWKEHAEETGTgrGWNIKYYKGLGTSTAKEAKEYFAALDHHKKTFAWTTDGDGNLIDMAFSKKRVEDRKAWLNAYEPG 694 
224055129  586 YESWKGSLAGNAS--GWSIKYYKGLGTSTSKEGKAYFQSLDKHKKDFIWMDEQDGDAIELAFSKKKIEARKNWLRQYEPG 663 
224106109  589 YESWKESLSGNAS--GWSIKYYKGLGTSTSKEGKDYFKNLHKHKKDFLWMDELDGDAIELAFSKKKIEARKNWLRQHEPG 666 
242062820  583 YEEWRTNLGASAS--SWTIKYYKGLGTSTAKEGREYFKDITDHKKDFVWEDDQDGNHIELAFSKKRIADRKLWLTNFQPG 660 
303276424  616 YENFKESLGDAGTk-GWSIKYYKGLGTSTSKEAKEYFAALAHHRKTFTWSDDNSGDLIDMAFSKKRVDDRKQWLTAYEPG 694 
297831176  593 YEDWKESMKGNAT--GWEIKYYKGLGTSTTEEAKEYFKNLGLHKKDFVWEDEQDGEAIELAFSKKKIEARKNWLSNYVPG 670 

225450069  667 TYLDQKEKLIKYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKIAQFSGYVSEHSAYHHGEQS 746 
186510360  673 NHLDQRQPKVTYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFVAFKKIARKEMKVAQLVGYVSLLSAYHHGEQS 752 
15229538   673 NHLDQRQPKVTYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFVAFKKIARKEMKVAQLVGYVSLLSAYHHGEQS 752 
255076711  695 TYLDMTGDDVRYDDFINKELILFSRADLMRSIPSVVDGFKPSQRKVLFSCFKRKLKSDIKVAQLSGYVSEHSAYHHGEAS 774 
224055129  664 THLDQNQKLIKYSDFINKELILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFVKEAKISQFSGYVSEHSAYHHGEQS 743 
224106109  667 THLDHNQKIIKYSDFINKELILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFVKEAKVSQFSGYVSEHSAYHHGEQS 746 
242062820  661 TYIDQQEKRVRYSDFINKELILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFVKEAKVAQFSGYVSEHSAYHHGEQS 740 
303276424  695 TFLDMTGDDVGYDDFVNKELILFSRADLMRSIPSVVDGFKPSQRKVLFSCFKRKLKSDIKVAQLSGYVSEHSAYHHGEAS 774 
297831176  671 THLDQREPKVTYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFTAFKKIVVKEMKVAQLVGYVSSMSAYHHGEQS 750 

225450069  747 LASTIIGMAQDFVGSNNINLLLPNGQFGTRHQGGKDHASARYIYTRLSPITRFLFPKDDDILLDYLNEDGQSIEPTWYVP 826 
186510360  753 LASAIIGMAQDYVGSNNINLLLPNGQFGTRTSGGKDSASARYIFTKLSPVTRILFPKDDDLLLDYLNEDGQRIEPTWYMP 832 
15229538   753 LASAIIGMAQDYVGSNNINLLLPNGQFGTRTSGGKDSASARYIFTKLSPVTRILFPKDDDLLLDYLNEDGQRIEPTWYMP 832 
255076711  775 LASTIVGLAQDFVGSNNVNLLVPSGQFGTRLQGGKDHASPRYIFTRLAPICRVIFPECDDALLDYLDEDGQVIEPEHYLP 854 
224055129  744 LASTIIGMAQDFVGSNNINLLLPNGQFGTRSVGGKDHASARYIYTQLSPITRFLFPKDDDGLLDYLDEDGQTIEPNWYMP 823 
224106109  747 LAGTIIGMAQDFVGSNNINLLQPNGQFGTRSVGGKDHASARYIYTQLSPITRFLFPKDDDGLLDYLDEDGQTIEPTWYMP 826 
242062820  741 LASTIIGMAQNFVGSNNINLMFPGGQFGTRAQGGKDAASPRYIFTKLSHITRSIFPKDDDILLNYLNEDGQSIEPTWYMP 820 
303276424  775 LASTIVGLAQDFVGSNNVNLLVPSGQFGTRLQGGKDHASPRYIFTRLAPICRAIFPEADDALLDYINEDGQVIEPDYYLP 854 
297831176  751 LASAIIGMAQDYVGSNNINLLQPNGQFGTRNSGGKDAASARYIFTILSPVTRILFPKDDHILLDYLNEDGQSIEPTWYMP 830 

225450069  827 TIPMVLVNGSEGIGTGWSSSIPNYNPRDIIANVRRLLNGEMMEPMDPWYRGFRGTIEKTDPTKqESVGYTVKGIIEEVNE 906 
186510360  833 IIPTVLVNGAEGIGTGWSTFIPNYNPREIVANVRRLLNGESMVPMDPWYRGFKGTIEKTASKE-GGCTYTITGLYEEVDE 911 
15229538   833 IIPTVLVNGAEGIGTGWSTFIPNYNPREIVANVRRLLNGESMVPMDPWYRGFKGTIEKTASKE-GGCTYTITGLYEEVDE 911 
255076711  855 ILPLVLVNGADGIGTGWSTSIPNFNPRDIVANIRRILDDECTERMHPWYRNFKGTIEEEIVK--GEIRYNITGKYEIVDE 932 
224055129  824 IIPMVLVNGCEGIGTGWSTFIPNYNPRDIVANIRRLLNGEMMEPMNPWYRGFKGTIEKGASKE-AGCSYTVNGVINEVNE 902 
224106109  827 IIPTVLVNGCEGIGTGWSTFIPNYNPRDVVANIRRLLNGEMMEPMNPWYRGFKGTIEKGASKEgGCSSYTVNGVINEVNE 906 
242062820  821 ILPMVLVNGSEGIGTGWSTFIPNYNPRDIVANLRRLLNEESTVPMHPWYRGFKGSIEKTVNTKvVGSTYTVTGIIEVVDN 900 
303276424  855 ILPLVLVNGADGIGTGWSTSIPNYNPRDLTDNIRRLLNDEEPERMHPWYRNFNGSLTEEIVK--GEIRYHISGAYEIVNE 932 
297831176  831 IIPTVLVNGSEGIGTGWSTFIPNYNPREIVANVRCRLNGESMVPMDPWYRGFKGTIEKTASKE-GGCTYTITGLYEEVDD 909 

225450069  907 TTLRISELPVRKWTQDYKEFLESIMTGNdk-----iKDPFIKDYKEHNDDTTVHFEVIMSEENLLMAKQEGLLQKFKLTT 981 
186510360  912 TTIRITELPIRRWNDDYKNFLQSLKTDN--------GAPFFQDVKAYNDEKSVDFDLILSEENMLAARQEGFLKKFKLTT 983 
15229538   912 TTIRITELPIRRWNDDYKNFLQSLKTDN--------GAPFFQDVKAYNDEKSVDFDLILSEENMLAARQEGFLKKFKLTT 983 
255076711  933 TTLVITELPLRSWTTDYKDFLENMLSPKek-----nAQPFITDYKEHHTDTTVHFIVTMTPENMAKAQKDGIEKKFKLCA 1007
224055129  903 TTLRITELPIRRWTDDYKAFLNSVTEGNrdengnlpKDPFIKDFRKYGDDATVVFEVLLSEENMMIAKQEGLLKKFKLTT 982 
224106109  907 TTLRITELPIRRWTDDYKAFLNSVTEGTrdengnlpKDPFVKDFRKYGDDAAVHFEVQLSEENMLVAKQEGLLKKFKLTT 986 
242062820  901 SRLRITELPIRRWTGDYKEFLESLGPDKnk-----dKVPFIEDVTAQGDNEDIYIEIQLSEGNMNIAKEEGLVKKFKLTT 975 
303276424  933 TTLMISELPIRSWTTDYKEFLENMMNPKek-----nATPFITDYKEHHTDTTVHFVVTMTPEKMAQAQKEGIEKKFKLSS 1007
297831176  910 TTIRITELPIRRWNDDYKQFLQSLKTDN--------GAPFFQDVKAYNDDKSVDFDLILSEENMLAARQEGFLKKFKLTT 981 

225450069  982 KISTSNMHLFDSNGTIKKYETPEQILEEFFHLRLEFYEKRKRVLLDNLELELLKLENKVRFILGVVRGEIIVSNRKRADL 1061
186510360  984 TIATSNMHLFDKKGVIKKYVTPEQILEEFFDLRFEYYEKRKETVVKNMEIELLKLENKARFILAVLSGEIIVNKRKKADI 1063
15229538   984 TIATSNMHLFDKKGVIKKYVTPEQILEEFFDLRFEYYEKRKETVVKNMEIELLKLENKARFILAVLSGEIIVNKRKKADI 1063
255076711 1008 KVSTSNMHAFDEKGGITKYSSPEAIMEAFVPLRLDAYARRRAMLIRQAEFELKRMSNKVRFILAVVDGEMTIGRKKKSVL 1087
224055129  983 TISTSNMHLFDSAGVIKKYDNPEQILEEFFHLRLEYYERRKKVLLENLEFELLKLENKVRFILGVVRGEIIVNNRKRADL 1062
224106109  987 TISTSNMHLFDSAGVIKKYDNPEQILENFFHLRLEYYETRKKVLLENLEFELLKLENKVRFILGVVRGEIIVNNRKRADL 1066
242062820  976 TIGTSNMHLFDSNGKIRKYDTPEQILEEFFQLRLEFYVKRKEALLKNIKLELKKLENKVRFIRCVVDNEIIVNNRKRADL 1055
303276424 1008 KVSTSNMHCFDANGGIQKYSNPEEIMKAFVPLRLKAYEKRRTMLIRQAESELKRLANKTRFILAVVDEKLSIGRKKKSAL 1087
297831176  982 TIATSNMHLFDRKGVIKKYATPEQILEEFFELRLEYYEKRKETMLKNLEIELLKLENKVRFILGVLSGEIIVNNRKKADI 1061

225450069 1062 FHELHQKGFTPFPKKSKSVEIAVAGATDD-TEEAEENTDA---VSKGGVRATDYEYLLSMAIGTLTLEKVQELCADRDKL 1137
186510360 1064 VEDLRQKGFTPFPRKAESVEAAIAGAVDDdAAEEPEEILVdpeSSSSYIPGSEYDYLLAMAIASLTIEKVEELLADRDKM 1143
15229538  1064 VEDLRQKGFTPFPRKAESVEAAIAGAVDDdAAEEPEEILVdpeSSSSYIPGSEYDYLLAMAIASLTIEKVEELLADRDKM 1143
255076711 1088 IEELEAAGYDKMPKTAK-----AAAAADA-EPAESGLSDIseeGAPAPADGASYDYLLSMPLWNLTQEKVDELVEEQRVK 1161
224055129 1063 FLELHQKGFTPIPKKSKAV---VAGATDD-KDEAEDSLEV------SGVRASDYDYLLSMAIGTLTLEKVQQLCADHDKL 1132
224106109 1067 LLELHQKGFNPIPKKSKAV---VAGATDD-TEEAEDSPDV------SGVRASDYDYLLSMAIGTLTLERVQQLCADRDKL 1136
242062820 1056 FLELRQKNFDPFPKKKKRAEPAAAGALEE-ENEENPEAEA--------AEPSDYEYLLAMPIGTLTLEKIQELIAEKQKL 1126
303276424 1088 VEELESLGFDKMTKTQK-----VSAAIDE-IAEGDEe------AADAVESGANYDYLLSMPLWNLTQEKVDELVTEKESK 1155
297831176 1062 VEDLRQRGFTPFPKKAESVEAAVAGAVDD-AAEESEEILVdpeSSSTYIPGSEYDYLLAMAIGSLTIEKVQELLADRDKM 1140

225450069 1138 NKGVDDLKKATPKALWITDLDALERELDEQDKNDARAEETRKQLK-SRVMSEAG--MKVSRQAPKN--PRKNNKKANNAE 1212
186510360 1144 IIAVADMKKTTPKSLWLSDLESLDKELEKLDLKDAQVQQAIEAAQ-KKIRAKSGaaVKVKRQAPKKpaPKKTTKKASESE 1222
15229538  1144 IIAVADMKKTTPKSLWLSDLESLDKELEKLDLKDAQVQQAIEAAQ-KKIRAKSGaaVKVKRQAPKKpaPKKTTKKASESE 1222
255076711 1162 TAEVEELHGTTDKQLWIRDLDAFDAAMDVFDAEDAKAAEELAKQQrAAARNQTKggKKALAKKKKAarAMDSDEDSEEDE 1241
224055129 1133 NGEVDNLRKTTPIVLWVKDLEALEMQLDVLDKYDAEAEEARKKLK-GDANGEAG--FKVSKQAPKN--PRKYTKKAINEE 1207
224106109 1137 NGEVDSLRKTTPKVLWVKDLEALEMQLDMLDEYDAEAEEARRKLKgGGAKGEAG--FKVSKQAPKY--PRKNTKKAINEE 1212
242062820 1127 VDDVEELKNTSPKSLWLKDLDAFEKELDLLDQMDLSEEEQREKRIkDGKKGRSKaaPKKQQRGKKAgsKAAVKKEKSDTE 1206
303276424 1156 EEEVAALHATTDKELWIKDLDAFEEALMAFDIEDAKQAADLAKQQrAAARNATKagKKALAAKKKKgkKKQWDSEDESSE 1235
297831176 1141 IIAVEDMKKHTPKSLWLRDLESLDKELDKLDRKDAKAEEERKAAQ-EKIRKKSGapVKVKRQAPKKpaPKKTTKKASESE 1219

225450069 1213 PAAETMdvs------------------------------asSAMEM---ESVPEVVKPKGRAAP-RKAPAKKKEMptsvl 1258
186510360 1223 TTEASY-----------------------------------SAMDTd--NNVAEVVKPKGRQGAkKKAPAAAKEV----- 1260
15229538  1223 TTEASYsamdtdnnvaevvkpkarqgakkkasesetteashSAMDTd--NNVAEVVKPKGRQGAkKKAPAAAKEV----- 1295
255076711 1242 d------------------------------------------------FSDDEFVPTKAKAKKaAAAPAA--------- 1264
224055129 1208 VSVETMgka------------------------------ssSAMET---ENAAEVVKPKGRAGS-RKAPAKKQEKpsp-- 1251
224106109 1213 VSVETTgts------------------------------ssFAIETassENAAAVVKPKGRAGS-KKAPAKMEKLspvld 1261
242062820 1207 d------------------------------------------------DDAAEPVVPK-RGGQqKKAPKKAPVDe---- 1233
303276424 1236 EEEEDDws----------------------------------------dDDDFVEVKPRKRAPVkLAVVKAAAEKpavak 1275
297831176 1220 TTESSY-----------------------------------SAMDTd--NNVAEVVKPKGRQPAkKKAPAAKEV------ 1256

225450069 1259 kdeDDDEVHELKERLAAYNL-ESSPDGSAAMEAEVPQVPAarkkepsrraaaqkkplasfteisddDED---DEDFEVEE 1334
186510360 1261 ---EEDEMLDLAQRLAQYNF-GSAPADSSKTAETSKAIAV--------------------------DDD---DDDVVVEV 1307
15229538  1296 ---EEDEMLDLAQRLAQYNF-GSAPADSSKTAETSKAIAV--------------------------DDD---DDDVVVEV 1342
255076711 1265 ---------------------KKAPSARAKKPTAAPASSAtsevseavsaqvseavsapppapepeSDD---EFEVAPKL 1320
224055129 1252 isdEDDEIESLKDRLKAYRL-DSSPEQSADMETDVLRVPAgrnaarkkpl-------aavsvisdsEDEpdlDDDFDVQV 1323
224106109 1262 dfdEDDEIESLKDRLNAYRL-DSSPEQSADMETDVLQVPArrgaarkkpl-------anvsvisdsEDEpnlDDDADVEV 1333
242062820 1234 ---EEFDIPALKDRLADFNInDSSPDYSAMETEITEEQNEklatkgpskrgggkkavssslvmiqsDDE---DDDFTLEE 1307
303276424 1276 aaaAAVKPADIAAA-------TAAPAPPAAIPEPVEDV----------------------------DSD---EDEFAPKL 1317
297831176 1257 ---EEDDMLDLAQRLAQYNF-GSAPAESSKTTETSKAIDV---------------------------DD---DDDEVVEV 1302

225450069 1335 VSAsdvkKKGG-RKPAANakAAAAKPAAAaaknKRGAANKQQPqllgqtllTEIFkpaeTLGISPEKKVRKMRASPFNKK 1413
186510360 1308 APV----KKGG-RKPAAT--KAAKPPAAP----RKRGKQTVAS--------TEVL----AIGVSPEKKVRKMRSSPFNKK 1364
15229538  1343 APV----KKGG-RKPAAT--KAAKPPAAP----RKRGKQTVAS--------TEVL----AIGVSPEKKVRKMRSSPFNKK 1399
255076711 1321 SLAerllQRAGaPSAAAAkvKPAAKPAAA----KKPAAAKAKP--------AAAKdefdFSGSEDDSEPAPVVKKPAPAK 1388
224055129 1324 KAVpetkKKGG-RKAAAAndKAAKPPAAT----KRRGPASKQSqglgqqllTEMLkpaeESGISPEKKVRKMRASPFNKK 1398
224106109 1334 KALpetkKKGG-RKAAAAndKAAKPPAAT----KRRGPASQQSqglgqkllTEMLkpaeGAGISPEKKVRKVRASPFNKK 1408
242062820 1308 VSEvqaqKKGRgKKPAAAvkPKAPAP-------RKRAPAQGKAtqk---kiDEMLqgieDNNTSPEKKVRKMRPSPFNKK 1377
303276424 1318 SLAerllRRAGeNGAAAArpVAAPAPAKA----KPAPVATKPPpadgafdfTEE-----ENDTPPKKKPAAAAKKPAAKK 1388
297831176 1303 APA----KKGG-RKPAAS--KAAKPPAAP----RKRGKQTVTS--------TEVV----AIGVSPEKKVRKMRSSPFNKK 1359

225450069 1414 ----SGSVLGSTGEEDETaeteenSGSASTSNSSGGESNEVVMPARTRPQRENRVQTRYVVSDSESD--QPtDDSDFDGE 1487
186510360 1365 ----SSSVMSRLADNKEE------ESSENVAGNSSSEKSGGDVSAISRPQRANRRKMTYVLSDSESE--SA-NDSEFDDI 1431
15229538  1400 ----SSSVMSRLADNKEE------ESSENVAGNSSSEKSGGDVSAISRPQRANRRKMTYVLSDSESE--SA-NDSEFDDI 1466
255076711 1389 ----KPAPAKKAAA-----------NSDDEFGSDAESDVEAIADVAPRAASSRRGGAARKVYKEESSdeES-DEDDFEDD 1452
224055129 1399 ----SGSLLGGIHKGDDT-------GIETMPASTSENADVIDVPAKARPQRANRKQTTYVLSDSES------EDSDFEQA 1461
224106109 1409 ----SGSVLGRIHKEDDT-------GSEPMSASSSENTDVIDVPARARPQRANRKQTRYVLSDSESE--K--EDSDFEQA 1473
242062820 1378 ----SGSILQRGSTAASS------ETTAEASPPSGSSAEPVGAAQPRRTARATKKPVYVTDSDPEDEvvELtDDSDFDVD 1447
303276424 1389 qtlaAAATKAKADTPKAKkskkaaDSDDESDFGSSDEEDEIVASVKPRSVAARRGGAARVVYAEDSE--SEeDEDEDAED 1466
297831176 1360 ----SSSVMSRLANNKEE------ESSENVAGNSSSEKSG-DVAAKSRPQRANRRKMTYVLSDSESE--SA-NDSEFDDI 1425

225450069 1488 DD 1489
186510360 1432 ED 1433
15229538  1467 ED 1468
255076711 1453 GD 1454
224055129 1462 SE 1463
224106109 1474 ND 1475
242062820 1448 GD 1449
303276424 1467 ED 1468
297831176 1426 ED 1427
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