Conserved Protein Domain Family
DUF5728

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pfam18999: DUF5728 
Family of unknown function (DUF5728)
This is a highly conserved domain of unknown function found in Platyhelminthes, with many of the sequences annotated as being the small conductance calcium-activated potassium channel protein. However, the location suggests that this domain belongs to the intracellular amino terminus of these transmembrane proteins, immediately next to the calcium-activated SK potassium channel.
Statistics
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PSSM-Id: 408769
Aligned: 3 rows
Threshold Bit Score: 363.584
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
VDN98199  470 GEYEDGMNMLASERSCTEQEATEDQDEDTLTNS-DMTRPKRPYYCQKAQQFRTSWRTQSVDTPSSIMNYGLSQDRALTMV 548 
VDM16732  469 GDADEFINLNISSKNSVEQETIEDQEDDTLMPSvDMTRPKRPYYCQKAQKFRNSWRTQSIANPQSTVEHGLVQDRSLTMV 548 
VDL18565  463 GECEEYMNMFASGKNSTEQENTEDQEEDTLNNT-DMTRPKRPYYCQKAQKFRTSWRTQSVETPSNVIDHGLAQDRSLTMV 541 
VDN98199  549 ESQSDSESMSPgNGIGQDRNAQVKVYLTRGSRNPVKTILVNHNANPM-AANADRLRARRQRTFSNRNQWRSVQLSPSHDT 627 
VDM16732  549 EPQPVSDVKNN-SGIITDRGAQVTVYLTRGSRNPVKTILVNHTASNMtAANAARLRARRQKTFSNRNQWRSVQLSPTHDV 627 
VDL18565  542 ESQSDSESKSTgHGTGQERNAQVKVYLTRGSRNPVKTILVNHNANIV-AANTDRLRARRQRTFLNRNQWRSVQLSPSHDP 620 
VDN98199  628 EIDR---RGDERSYNASLRESRESYVGNRGNIK 657 
VDM16732  628 ETEKqgwKGDDKLHNTSLCSIRESYLNNRIRVR 660 
VDL18565  621 EMDR---RAGERSYNASLCDSRESYVGHRFNRK 650 
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