5TIH


Conserved Protein Domain Family
CyRPA
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pfam18638: CyRPA 
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Cysteine-Rich Protective Antigen 6 bladed domain
Plasmodium falciparum Cysteine-Rich Protective Antigen (PfCyRPA) is a 42.8 kDa protein of 362 residues with a predicted N-terminal secretion signal. It is part of a multi-protein complex including the PfRH5-interacting protein PfRipr and the reticulocyte binding-like homologous protein PfRH5, which binds to the erythrocyte receptor basigin. PfRH5, PfCyRPA, and PfRipr colocalize during parasite invasion at the junction between merozoites and erythrocytes. The complex seems to be required both for triggering Ca2+ release and establishment of tight junctions. PfCyRPA adopts a 6-bladed beta-propeller structure with similarity to the classic sialidase fold, but it has no sialidase activity and fulfills a purely non-enzymatic function. Each blade of the propeller is constructed by a four-stranded anti-parallel beta-sheet.
Links
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Statistics
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PSSM-Id: 408420
Aligned: 4 rows
Threshold Bit Score: 432.307
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5TIH_A        12 LSFIKNNVPCIRDMFFIYKRELYNICLDDLKGEEDETHIYVQKKVKDS--WITLNDLFKETDLTGRPHIFAYVDVEEIII 89  Plasmodium falc...
EDL45413      37 ITTIKSPIHCITDIYFLFRNELYKTCIQHVIKGRTEIHVLVQKKINST--WETQTTLFKDHMWFELPSVFNFIHNDEIII 114
XP_002258289  36 ITTITSPVHCIADTYFIFRNELYKICIQHVNKGRTEIHVIVQKKAKNK--WETKQKLFEDKMWFHLPFVFNFVQNDEIII 113
CAQ40450      33 ISKDTNMKQCYSEHFVNFKGEIVQVCLDKVPYGSLNKYNILISSYGEDkkWTMQSKALDNYTTKLLKYFYSFTNNEQLVV 112

5TIH_A        90 LLCEDEEFSnRKKDMTCHRFYSNDGKEYNNAEITISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKDDNKKDDI 169 Plasmodium falc...
EDL45413     115 VICRYKQRS-KREGTICKRWNSVTGTIYQKEDVQIDKEAFANKNLESYQSVPLTVKNKKFLLICGILSYEYKTANKDNFI 193
XP_002258289 114 LVCRYKGMT-KGEGVACDRWSSTTGTNYNKGNINIDAQALTKMNLDSYASFPIPIKDKAIIHICGVHSYEYQNVNQNNFI 192
CAQ40450     113 VFCFNKNLS--NPPYECYRSITNDLKTLKTEKIQIDLRMFEPSSFNDYALNSFDLFGVGHFLICGINNKRNSKPNVGLLV 190

5TIH_A       170 LCMASHDKGETWG-TKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGD-NINNVKNVNFIECTHE------KDLEFVC 241 Plasmodium falc...
EDL45413     194 SCVASEDKGRTWG-TKILINYEELQKGVPYFYLRPIIFGDEFGFYFYSRIsTNNTARGGNYMTCTLDvtnegkKEYKFKC 272
XP_002258289 193 SCLASEDKGTTWGdIKIHIYYDQFQEGVPYFYLRPLVFNDEFGFYLYSRIsSNNADRGGKYMKCILNptnsrnKEYTFKC 272
CAQ40450     191 ICHASADGGFTWK-KKLNFYHPNMDKNTTYESLVPKISGNEIGFQYLASKvSLTK-----YFKCYYK------KDHDFEC 258

5TIH_A       242 SNRDFLKDNKVLQDVSTLNDEYIVSYGNDNNFAECYIFFNNENSILIKPEKYGNTAAGCYGGTFVKIDENRALFIYSSSQ 321 Plasmodium falc...
EDL45413     273 KHVSLIKPDKSLQNVTKLNGYYITSYVKKDNFNECYLYYTEQNAIVVKPKVQNDDLNGCYGGSFVKLDESKALFIYSTGY 352
XP_002258289 273 TNVNLIKEDKSLQNITKLNGYYVTSYAKKNNFNECYLYYTENNAIVVKPKVQNYELNGCYGGSFVKFNESKALFIYSTGH 352
CAQ40450     259 QDVNMVREQSYIWDIAKIRGYYVSPIS-DGKAPPTQLYYMYKNTYLMPIEVPKSIGTEYNRGKVFQLDNQKLIYSYANEK 337

5TIH_A       322 GIYNI 326 Plasmodium falciparum 3D7
EDL45413     353 GVQNI 357
XP_002258289 353 GVQNI 357
CAQ40450     338 EAYTY 342
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