Conserved Protein Domain Family
Saf_2TM

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pfam18303: Saf_2TM 
SAVED-fused 2TM effector domain
Predicted pore-forming effector domain directly fused to predicted SAVED sensor domain. Binding of a ligand via the SAVED sensor is predicted to activate the Saf-2TM and initiate a cell suicide response. Component of a class of conflict systems reliant on the production of second messenger nucleotide or nucleotide derivative.
Statistics
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PSSM-Id: 408111
Aligned: 9 rows
Threshold Bit Score: 137.118
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_044832596             2 KKAISYFIEKAADWFFRKRSPALI--VLRVGGSILLATLVG---SWALTLVYKDA-ERSLELGYQSSS-TAQLFFTIGFF 74  Thala...
Q07GQ9                   3 KRLFESFATKAIDWWFRVSAIERF--LITTAVALLIAIFGG---VPLIAELLRIA-IGAVPEGYLNAQgKIDAVAGWILG 76  Roseo...
KRA05690                 3 KDTLDWALREFVRFLVRPRGFEGR--IAQGCVPILVALLGW---DWFVKFAAPDG----HSLELGSANtIPEWIQLPLIV 73 
WP_055971870             8 WNTLDFVVRSLVSWFVRARHAESW--IFRGAVAALVAIHGA---NWVFKYSGTIG-GESGSIEFGTAGaVPDSILWIITV 81  Amino...
zhongguo:PT7_2196        3 WDTVDFVIRSAARWFFRIRNAENW--IFHGAIAVLIVIHGA---NWIFKYSGPIF-GTPSSVEFGTVGsIPDGILWSVTA 76 
PRJNA277796:VN23_11985   7 LNRILNILQEFGVLYLRRTPAGM---FMKYGVLLMLGGPLL---NISVSSYFKDDkGNFIKASLNSSE-PIWWISAGCFA 79 
WP_005307243             8 MYRLLHWGDLLFKWYTRPKSK-----LFTIGKFLVVSGLSSiglTTALKIAFITPeGYELTASFFEND-----TGIFILL 77  Photo...
GAE36829                10 VILVIGAIIFFRNMVIQKKEQGYAavLFTTGIVLITNAFGTf-fDNVMQILTMLQ-SNSVEDSLRIQE-SFSDVNYTSLF 86 
WP_062061437             2 KKHFDYFIRSWIDFIFLRPLPGMR--LIKWGVTLILATFA----GFALTVGIPTE-NGRIDVSFDSGAgIPAFVLALVLT 74  Sphin...
WP_044832596            75 VGIATIVWGAVWEYQRYRDESKRNAKKKTIVIEQRGLVDTSDSPLGEYVKR-NCSWLVDTIVNDIRERiIDNVITRPDLA 153 Thala...
Q07GQ9                  77 IGFLMIVVGLGLAIARFAGDAKSRSKKRIVVIEGRGLRDDDGAPLEGTVGK-QVEGQVVPVLLDLRRR-MDGKVIEPERA 154 Roseo...
KRA05690                74 LFSTIFTFCMLISWRRLVRDNELRNRKKVIVIEGRGLREDDGSPLTEAVPA-DIVGNRIGVLLDLRQR-RDGIVVDPKEL 151
WP_055971870            82 VCIALMLGSAVWAWIRYANEQKRLARKKVFVIEGRGLRDDDGSSLKSAVPE-SITGTRIDYMLDLRQR-KDGVIVEPEDL 159 Amino...
zhongguo:PT7_2196       77 VCALLMIASPVWAWKRYVNEQKRLSRKKVFIIEGRGLRDDDGSPLKTAVPD-SIVGTQMDYLLDLRQH-KDGRIVEPEDL 154
PRJNA277796:VN23_11985  80 LGFIFTAIGGYLAWQNY----RIQQRKRIIAIEVRGLTQSVDSPLVAAIPI-LILGQREELLIDVRNL-VDGTPAQRQKA 153
WP_005307243            78 ISSCFIIVGFFLIIYDALLTIKDSGKANNILVEHIALFKPLSSSFLSTVTK--AKGKMRCVKIDLSEYyRDGVLSEPSDA 155 Photo...
GAE36829                87 IGVVLLLTG--WLFSRY-----IQNKMFILNINGYYDRRIEGHHNELSLSTfEFKEREVDFVRLFKIN-----KMTPTLA 154
WP_062061437            75 LASLMIIGGALWLIVDL----RRESRKQVLAIELRGLRDMSGQPLISAVPT-GIMDRRVSLLLDIRQG-ADGVLLSPEQA 148 Sphin...
WP_044832596           154 L 154 Thalassomonas actiniarum
Q07GQ9                 155 L 155 Roseobacter denitrificans OCh 114
KRA05690               152 L 152
WP_055971870           160 L 160 Aminobacter sp. DSM 101952
zhongguo:PT7_2196      155 L 155
PRJNA277796:VN23_11985 154 L 154
WP_005307243           156 V 156 Photobacterium damselae
GAE36829               155 A 155
WP_062061437           149 L 149 Sphingobium baderi
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