Conserved Protein Domain Family
mCpol

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pfam18182: mCpol 
minimal CRISPR polymerase domain
Minimal version of the CRISPR polymerase domain. Predicted to generate cyclic nucleotides, potentially sensed by CARF domains which in turn activate various effector domain including HEPN RNases, CARF sensor and effectors are found in conserved genome contexts. Part of a broader class of conflict systems reliant on the production of second messenger nucleotide or nucleotide derivatives. Implicates CRISPR polymerase of the Type III CRISPR/Cas systems in a nucleotide synthetase functional role.
Statistics
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PSSM-Id: 408011
Aligned: 11 rows
Threshold Bit Score: 118.954
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KPL82627       326 LIQFDGDGIGKKIDYLLa-RDDAENAHRRFSQNIGAFSNAVRGTINPNq--GGFLIYNGGDDVLLLASLer-glQLAIEL 401
jgi:Metho_2186   3 YIAIDGDDIHQKFEKCL--LESDEKNIVRTSKEITNTIDRIIDHLQHE---SLRIVFSAGDCILCKCDA-----VDLIDL 72 
EFE95240         2 YIAIDGDDVGRKITSSY--LSNSEERLKYISNKLNDTTIRISKMLLSN---GFEIIFQAADGVTAKT-------DNEVNL 69 
KFC24821         3 FVTIDGDDIGRRLAACY--LSNDIKALEATRELVDLKTHQISNLLTDL---GYRVLFCAADGVTAHSN------DNIVDD 71 
KJU83610       377 YFGFDGDATGDYLETAFvmSGIDEEEVQMRSNILREAINKLKKLIKKTtkdHKSIIFAEGDNILFKSKFd---nTLLNEI 453
Q8YWV2         365 YYGLDGDDTGKILEELFl-SCSDESSFRKLSKDVANAISKISKFVTDKl-gKNAVVFEAGDDLLFKGNLq---eDMLFEM 439 Nostoc sp. PC...
KZF04499         2 FAIIDGDDIGPTIEALL--LSNDLNGFVERSAEITTSIKLLARKLNEIs--QASLLSLGGDSMLFEVSDva--nREFSEF 75 
KIJ78742         1 MCIGDGDNIGDVIDFYL--LSQNLEEASKFSLQVKAAIEHIAELAKDEi--NASVVYVAGDDICFMVPAnlnimNSLVSY 76 
WP_015209627     7 ICLGDGDNIGDTIEFHL--LSGNIEEASKFSSQVKTAIAKIAELVKDEi--GASLVYVAGDDICFVVSAeknikDYLVKY 82  Cylindrosperm...
WP_015773835     3 FYAIDGDDIGAKLEKFA--LLGDLKSIQMLSEEVCESLVQLKTYFEEN---SATIVFCGGDSLLAYS-------KHEIDL 70  Desulfomicrob...
KPA14932         2 YLAYDGDKVGRTLESLL--IDNNELKIEEYANTVFEALNSLKSALIDI---GCRIIFASGDSILATT-------NKYFDS 69 
KPL82627       402 ARTYQEMVgdgfnGFTATASAGIVIAHHLTPLSKALTL-LRSAERRA 447
jgi:Metho_2186  73 SNYLDKIGn----TNTVSVGIGDTLEKTYIAFKYARSI-GKNSIVKY 114
EFE95240        70 NFVFDKIKsysfdEITFSAGVGANLREAYVALLNSKSN-GKNMISIY 115
KFC24821        72 MRLYQSIEniaglELAFSVGVGETLREAYVALLFAKST-GKARLCNF 117
KJU83610       454 QSVYKKET-----GLSSSIGYGKTLRDVMIALRLAKAK-NGESLVGI 494
Q8YWV2         440 QAMYSQLTp----GLTCSIGYGRSFQEVYLALKLAKTQpGKNAIVGI 482 Nostoc sp. PCC 7120
KZF04499        76 LHYWNANC-----KVKVSAGLGHDLQSAFLALRMAKST-GKQRVITF 116
KIJ78742        77 SEFFLVST-----GKTMSFGVGKTSVEALISLRKAKVS-GKGRVVTF 117
WP_015209627    83 SNFFLKTT-----GKTISFGVGRNSVEALICLRKAKVS-GKGHVVTF 123 Cylindrospermum stagnale
WP_015773835    71 NLERLSLG-----GLTFSAGIGANCCDATLALKKAKGL-GKRRIEVI 111 Desulfomicrobium baculatum
KPA14932        70 ELIKRKYG-----NITFSLGIGNTPLEAMLALKKAKSK-GFAECLFY 110
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