Conserved Protein Domain Family
IES5
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pfam17335: IES5 
Ino80 complex subunit 5
The INO80 chromatin remodeling complex is known to be related to DNA repair in yeast, mammals, and plants. In yeast, the INO80 complex is recruited to the DSBs (DNA double-strand breaks) through the direct interaction of its Nhp10 (non-histone protein 10) or Arp4 (Actin-Related Protein) subunits with phosphorylated histone H2A. However, the ortholog of yeast Nhp10 does not exist in mammals. The Nhp10 module consists of Nhp10, Ies1, Ies3, and Ies5. These yeast-specific subunits cross-link to the N terminus of Ino80 and form a stable complex in-vitro, which helps high-affinity targeting of INO80 to nucleosome-binding.
Links
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Statistics
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PSSM-Id: 407440
Aligned: 10 rows
Threshold Bit Score: 110.569
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003667573   7 LEKELHKLVVKNDEFVKQDAALKKEYTTLLRKINSVVAVLKELDPEYfeqqrnhDTAEPRLISVGALQKVPKLEWYNRQI 86 
Q6FQM8         9 LEKEYRKLTARNDDIIRQEATSKKEYATFSRKETSIITLLQSLEPTLqdm-helKNNEPRLISEETIAKVPGLSWYNEQI 87  [Candida] glabrata
Q75D09         3 LDQEYTKLVSRRDELQKQEVTLRREFTTLVRKIASITAVLETIESPQ--------VIERNLPSDEVLQKAPGLQPLIEML 74  Eremothecium go...
XP_003646533  14 LEQEYNKLVSRRDELQKQEITLRREFTTLLRKIASITAVLETLEDRE--------ILERKLPSKETIAKVPELQYLVDSL 85 
CCF60530      10 LEKEYQKLSLRNDELVKQDSTLRKEYTTLLRKASSLASVLKVMDSKLae---qcEIEQPKLIGDRALKLVPGLQWYNDQI 86 
XP_003680268   1 MEGEFKKLLSRNDELSKQEATLKKEYSTLLRKISSLACVLGKTEAEV-------ETDEPRLISEAAVARAPALQWYNEQI 73 
CAR26155       8 SETDYKKVLSRNDELVKQETTLKKEYTTLLRKISSICSVLDQLEGET--------AETPGLISNRSLKRVPGFQWHNDQI 79 
CCC67990       7 QEKDLSKLTSKNDELTKQDASLRKEYTTLLRKMTSVISILSDLEPGFqdk--ytNNDVPTLISEETVNIAPKLQWYNEQI 84 
CCE63191       3 SEKQYQKLVSRHDELIKQDLTLRKEYTTLLRKCQSLFYYLNN----------------DKLYNTRIIDKVNRSIGFTMPS 66 
CCK69467       9 TEKDFQKMVSRNEELAKQETTLTKEYTTLLRKSSSLFRVLEQVDKDList--stQREQPKLISQKVLNLVPELKWYNDQI 86 

XP_003667573  87 TRVIQNt-NGNENFELPNELIDSYKLYKDSPLLYKDIL 123
Q6FQM8        88 KLVQES--GDKDDFDVPPELRESYELFKGLALLPKDGK 123 [Candida] glabrata
Q75D09        75 VTLDE---TPLAEIEIPEKLMHSYELFRNTPLLYKDNP 109 Eremothecium gossypii
XP_003646533  86 QSLDELl---LEQVQIPEKLMHSYELFRNTPLLYKDNP 120
CCF60530      87 NLVTQSfdNDNEEIEIPKELLDSYTLCKDTPLLYKDSQ 124
XP_003680268  74 SLI-QSlsQEDGNVPIPPELAESYKLSRDTPLLHRDLH 110
CAR26155      80 NLL-EKlsQENQEITIPTELIDSYKLYKDTPLLHRDVQ 116
CCC67990      85 EQISK---LKIEDITLPEETLELYNLYKESPLLFKDLH 119
CCE63191      67 SRYRKNrsQQKKT---SDKLSKDENDENDSMAITKDEI 101
CCK69467      87 LLAS----ADPDKFSMTQELQDSYDRYKSTSLLYQENQ 120
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