Conserved Protein Domain Family
GEP5

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pfam17053: GEP5 
Genetic interactor of prohibitin 5
Genetic interactor of prohibitin 5 (GEP5), also known as required for respiratory growth protein5 (RRG5), has been shown to interact with prohibitin ring complexes in the mitochondrial inner membrane that regulate cell proliferation as well as the dynamics and function of mitochondria. It is required for mitochondrial genome maintenance and is essential for respiratory growth.
Statistics
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PSSM-Id: 407225
Aligned: 11 rows
Threshold Bit Score: 177.544
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006685426  10 VLQRIRRLPFDSYTQQCLQKHARQqfstplkysyshsgkpvDAKKYNRFIKICDEILIYE----------DWNKLTMLFD 79 
XP_003668479  12 LLSSLQNLPLHSNTLAQLERKCLTr---------------nIKATKSFKIPLLTLINSYEkaqasgqsklSNKTLESIIY 76 
CCE93204       9 LLKALEKLPLHSKTLDLLACKLK------------------GDELKTVIIPLAKLVSNLEssra---etqRIKALESIIY 67 
A7TRR5        15 LLESLERLPLHKPTLDILERRI-------------------HVADLPFMEEYVGILNEYEiskinskvenESRALEKIVK 75  Vanderwaltozyma...
C5DN25         4 avRALEKLPLDIRTLELLERKL-------------------LKKSLPGFQELAQQYTADG----------SSKSLESIVH 54  Lachancea therm...
Q74ZX6         5 IQRIVSRLPLHRATSEVILAYLSKq----------------QAQYPTERIELVEPLNDFLrkg-------ghQGLQRLVF 61  Eremothecium go...
XP_003646184   8 VLEIVSRLPLHAHTKKVIADNVGS-----------------VGKGEFKRVDVIEPINRYLlsg-------evSYLRRVIF 63 
CCK71263       8 LLRELRSLPLHSLTLARLSRHVA------------------ATKSIPRLKHVAETLQNFHdvpst-kkhtQYKILTTLLL 68 
ABN68339      15 LCRRVYKLPLSRAMISRLMDLSKHkfttin-----pysprfSSTKFHNYMTLLDDILVEE----------KYSRVHDLLD 79 
EEQ36602      27 LYRKIGRLPLDVKSISLFKQSLRYefsskrs---fhkyagvDPKKYTSMVSLLDDILIYR----------KYKRIPELLD 93 
C5DSN0        13 LSRSIRQLPLHIETQKVLEFYC--------------------RNSSYKSLLVAQDISEFEkhn-------dhKYLEALIQ 65  Zygosaccharomyc...
XP_006685426  80 YIFkdvmgsESY-PEQYGALKKFESYNYDQVRDIYP-QVHLFKrldvpekyhQEFDKEL--KQEKDD------FSLVNYF 149
XP_003668479  77 HTY------FEW-TNDLASHLKPFQRQYSTLLTFWPhIYHSKI---------DSKKNSIilTWNKSSnsknmlRELLSHL 140
CCE93204      68 HTH------FVW-GSPLPVHLKMFQSHYTDMLMHWPyERHRSIln-----meKPRSTSLryRWEDSS------KTVLSMA 129
A7TRR5        76 KTH------IVWnNDKFPNHLEKFKNHYMELLHHWPyEFHSDVln-----maRPGTGSLiyLCLNND------DRFFNFY 138 Vanderwaltozyma...
C5DN25        55 LTY------FHW-CNEDAPHIKKFREHYAELRDHWPyEFHRSIls-----mdTPKTQSIrfLWSSNS------PKVLSKM 116 Lachancea therm...
Q74ZX6        62 HVH------FQL-MLRAPEHLRLLRRHREELQRFWPyERHHSLla-----lsDVRSQSLrrLWEDGQ------EEVLQQM 123 Eremothecium go...
XP_003646184  64 DVY------FRI-LNPKAEHVRQFERYLKELQLFWPyERHSCLls-----geRPYKDSAryLWSRNN------AKVLDIM 125
CCK71263      69 QLYcqwdnsFSR-LSHLPPHLAPFEQDFPGLVRIWPrESHLSLkq------sTKGHATLkhAWVTNN------KHALQM- 134
ABN68339      80 LIYklpassQSW-------KDKFLTIDYKELENHWP-QVHAIDeitsdpkylEAYREKQr-AEKNEE------VSVVKHF 144
EEQ36602      94 EIYkrkipsPSW-------ATEFFSTKYSAWKPFWP-HVHLIYefgn-eksiSVYRKELsrMEPENS------FSLMKEL 158
C5DSN0        66 KTH------FLW-DNPLPPFLKRFQLYHKELTNHWPyEYQRSLls-----msNPRKESQgyLWRDGK------ELALSNL 127 Zygosaccharomyc...
XP_006685426 150 KFDANtipd-------------------------------iplISRNqlndehekeemkKVLNHVKQMYNFIASKE-NI- 196
XP_003668479 141 NYTQSlv----------------------------------pqKKDFq-----------VIFKKIYQHYIFLSLNP-SLc 174
CCE93204     130 EYSKNpwiedni------------------------lskkltiIQRD------------LLFHSVFSHYLFLKANP-RLc 172
A7TRR5       139 KSQINnkwfnsv------------------------dqykltdEQRV------------SIYNDIFKQIFFLKRHT-TIs 181 Vanderwaltozyma...
C5DN25       117 SYEKYahdteer-------------------------psrlteLQRT------------VQFHEVFQHFLFLKSRP-HLc 158 Lachancea therm...
Q74ZX6       124 QYCRHhwlregdv----------------------peryaltqAQRE------------EVLHRVFAQYMFLKQRP-ALw 168 Eremothecium go...
XP_003646184 126 RYDRHlwlrdrepkfsldsifgepftqqlqylrhekdkntlgeTERI------------ALLKLIFSHYLFVKSRP-TLc 192
CCK71263     135 SFDAAaanp------------------------------tsgnIELR------------GSLRQILSHYQLLYNNM-RMf 171
ABN68339     145 GLKSKrdnqs----------------------------paltmIRKYsdvdq--ddsipQVLKNVQELHKFLFKNQaVF- 193
EEQ36602     159 ALSLPkndip-----------------------------ltplPRRTsssr-----pmaELLKKVQEFHAFISKHAnIL- 203
C5DSN0       128 RFEKHrwadeni-------------------------ierlspEQGT------------QLLHSIFHQYFFLKSHA-RLc 169 Zygosaccharomyc...
XP_006685426 197 ---THLKLRPMEVTYpsNKYGLPLHIIQRDKLLKDKLIYVKSVVNRYKPI--PASILDQLGQIT 255
XP_003668479 175 sngKRLPSPIVEIPM--NAMGYDIPKKRINNLLRSKIARTWNYLAITNPIl-NLENEAQLDEII 235
CCE93204     173 nngRNLPIPIVEIPM--RPLGNDIAVSRIKNLFKSKVAHTYRILAIENPVl-SRGSENILSEII 233
A7TRR5       182 evnKNM-VPIVEVPL--KPIGCDIPACRIKNLFNKKVDYIWKLLSLSSPAi-SLSHEKIIMNIL 241 Vanderwaltozyma polyspora DSM 7...
C5DN25       159 ktrKGLAVPIVEIPM--KPLGQNIPEVRVRNLFKRKIAYVWKVLALDSPAl-SRQNELSLAKII 219 Lachancea thermotolerans CBS 6340
Q74ZX6       169 s-vRRLPIPVVEIGM--TPLGFDIPDVRVDGLFKDKTKSVLRLLYREHPAl-TPAAEEDMLRII 228 Eremothecium gossypii ATCC 10895
XP_003646184 193 g-hKNLPIPIVEVGM--SPLGEDMPDVRIDNLFRKRSKATLKTLLHDFPPl-SREVESLLHSII 252
CCK71263     172 g-kIKLQVPVAEIPL--NVFGEEIPACRTANLLQRKVGYVKRVLIEELPAlyNTECIAELTAII 232
ABN68339     194 ----DVKIPPLEVFYptNKVALPIHPRERNKLLKKKVASIRNVFKSLRPI--AEDDLRQLYEfa 251
EEQ36602     204 ---SDVKIYPLEIHFepSRLGLPLSIAVREKKLRDKVSYAKHLLRTYKPL--DKEDLDHLICIA 262
C5DSN0       170 ynnRKIPVPIVEIPL--RPMGNDVADCRIRNLFKRKTAVVWNLLAWENRPl-STRNEQLLGEII 230 Zygosaccharomyces rouxii CBS 732
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