Conserved Protein Domain Family
8TM_micro

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pfam17028: 8TM_micro 
8TM Microsporidial transmembrane domain
This is a family of largely microsporidial-specific proteins that carry eight transmembrane regions, in two blocks of four. Such an arrangement of TMs suggests a transporter function of some kind. There is a highly conserved NFLNW sequence-motif at the C-terminus which might be of functional importance.
Statistics
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PSSM-Id: 407208
Aligned: 7 rows
Threshold Bit Score: 156.092
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EJW03961  15 RMFlpleKILFYKYNLNYQQELAYQSLLNENSKPDMVSGLLYTIRRKIPPFIDtl----------lvLILDFLSGSMMSC 84 
EIJ88566  23 RWF----DISKCLSRYSYYDLVEAEQYIQGNPFAGKPSITLYYFTKTLLLLNIskaysvhtfmygitGVCDFTAGYLLDC 98 
EHY65155  23 RCY----CPSKLLSRYSYYDLTEAEEYIKGNPFADKPAITLYYFTKMLSLISIggrysvhsvlftvtALCDFMSAYLLGT 98 
Q8SWF4    17 RSY----DVPSLCYNYHSPEANYQQEFLRPPAIPTVYQVIPMKYFTCVS------------------GACDLIVSRLIGS 74  Encephalitozoon cun...
EOB11743  18 RAF----SLVFY-LPFHYEDDHFEL---------ITDNFILLRVIKCIFY-----------------TLLDILTSFILKS 66 
EPR78139  24 RKY----NILNL-LEFESVDVVYEETFRNK--INSIQHLICSIIPKTNFFLTN--------------LICDIILWLMLND 82 
ELA42313  18 RIV----DIP---SKIFIKDHSKEILLLRDFKINE--------FNTCLFNILC--------------SLADLLFSLKVRS 68 
EJW03961  85 KDYYFFSSFIPGNLFnSLETFLITLIykknklnqkniytkvl-----------------------klcllalnvycipfm 141
EIJ88566  99 PVYFLVTSLLPNEIY-SIICLLIVVCy----------------------------------------------------- 124
EHY65155  99 PMYFLLTSFLPSEVY-SIICLVAVLCy----------------------------------------------------- 124
Q8SWF4    75 ERYFIYSSFLPADAI-SIENLLLVLMkkgyediasvllv-----------------------------hlsvfyapllsa 124 Encephalitozoon cun...
EOB11743  67 KTYLVLSFILPPSKT-SLENLLCSLIgsnwiyddliyyllcnfsifyyplslqfvieqifsnhdsflnsfysnqnlykgy 145
EPR78139  83 MRYIIFTSFLPYDFI-SIENLMLAFLdkcaylkyili----------------------------------ffdlhyvcy 127
ELA42313  69 FDYFLLSSLFPNDLS-SLENFIIHFKiqelypflcfyepfyllklps--------------kfsnlfhlnillgtnlirg 133
EJW03961 142 sDSLILNYAILFFLKKQSINNVETANi--hNVTPFWFMNIYMFPEYIYYINVILFITYIYLSSLYSlcdlkGfRTKMLLF 219
EIJ88566 125 -KKKALAKYVGPVLALLCAEGSYDRCa--pGINAYWYINMQMFKEYQGLFQDMFRASHYFLLSLTLfs-rlI-STKLYLI 199
EHY65155 125 --RKILLRYTAPLLALLCMEGTYTKCa--pGINPYWYINMQMFAEYRELCRDIFQAMHFFFQALTIys-qcI-STKLYLT 198
Q8SWF4   125 sNAYVLSYLYP------AYEKDYENAhr-pSLSITWFFHLNIFPQYARYFYDVFYALMLYLFSIVP-----R-GQKIEIL 191 Encephalitozoon cun...
EOB11743 146 fKRSLLDYLIP-NFNLIEYNKEYSKChe-pSFNILWFFFLHIFEQYSHLFFHYFYFVFIFLMKSVK-----G-IAQLEII 217
EPR78139 128 lDCSLFDILIF--ILSYNYSKEYLSVnhypNFNIFNIYFLHGIKQYNIFAYESLIIIFLHLINMVG-----K-EHFYFIL 199
ELA42313 134 rSVSLLNSLSTVYLNGLNY------Chf-pSLSGFWYLLMCMVEQYSGLSYTLNLIYGNFL----------S-DKDPRLI 195
EJW03961 220 SLFNQglfcgTTYKNYLMI-----ALTMKnlpffDNWMNLLSIFGYIDSFLSYKFRLTDSINLNFVNWAQLLFFIIFLLG 294
EIJ88566 200 MVFKD-----LGYRGYAVLwcilsLEKFSndrvfNLCLGLCSIGVFIEYLVWYMLIYCGVGNMNFLCWSNVITIISTGIA 274
EHY65155 199 MVFKD-----LGYRGYILVwcilsIQKTErkqifNLLLGLSFLGAVIDYLVWYMLVLCGVGNMNFLCWSNAVTIVSTGVA 273
Q8SWF4   192 LLFKP-----SNYKSYLLY-----IAD-------SPLAHFYLLVFILESYVQYLFRVRGVGNPNFLNWSYLIFTCLFILE 254 Encephalitozoon cun...
EOB11743 218 CLFRS-----STFKHWLLF-----ICK-------DKDLNIYVLLFIMYKYVEYLLFVEGLANPNFLNWITFVFVSFYLsk 280
EPR78139 200 CCFKY-----SNFKSFLFL-----LLSKK-----IKYTNELIVLLICMQYLLWGVGRTPAVNLNFVNWTALVF-----YG 259
ELA42313 196 PVYKNg----SSFISYLPF-----ILK-------SKFLNLYFAIALVFEYLYMNFKCSEIVNTNFLYWTSLLFVSLYIWD 259
EJW03961 295 FKYYIVVIDK 304
EIJ88566 275 TVLHESNVQK 284
EHY65155 274 ALLHEKSVRN 283
Q8SWF4   255 RRWKILMKQK 264 Encephalitozoon cuniculi
EOB11743 281 kylkqsnki- 289
EPR78139 260 VLAYVYCMKK 269
ELA42313 260 LKFGSLSNAK 269
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