Conserved Protein Domain Family
SIL1

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pfam16782: SIL1 
Nucleotide exchange factor SIL1
This family consists of fungal SIL1 nucleotide-exchange factor proteins.It interacts with Hsp70 (heat-shock protein of 70 kDa) Bip.
Statistics
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PSSM-Id: 407047
Aligned: 24 rows
Threshold Bit Score: 258.775
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCE64460     244 NYEFTKEFKVIRDIYnk-kaRlTNSEIKEIEAKLEELMEFTHDYKHGMKIITHEFELL-KSI------SLSDKLPVSLRE 315
XP_004197374 150 LDTYTDSVRIVKDFPt-------NSDVSDLDKALDVLEDLSHDIEFGARMTSDNI--LfDNLlritsnEIADPRHLEFKQ 220
XP_007373452 132 LNNFDAAMEEAGQFDv-------GKDVERFKLALDTLEDLSHDIEFGVRITRDGP--TtKNLikv-atAYQDT---DVTD 198
Q5A360       134 LSNFDAACSEIESFKp------hESDVERLHLALDTLEELSHDIEFGVKLTSDKA--IfQSLvni-anGASDP---KITE 201 Candida albican...
EER32665     151 LNDFDSASLEVEGYKp------nASDMDRLNTALDTLEELSHDIEFGEKLTTDKN--IfQSLlni-adTANDA---KVEE 218
XP_001525130 177 LTNFDSALNEVEQYDahlqtQtENNNKERFELALDTIQDYVHDIELGVKLTSSKDSTVlRKLidl-aeS-GDG---ELKS 251
CCE45203     152 LTDFTSAVEKVEEYDqskldD--VTEKERLIKALDTINDLSHDIELGEQVTSNTV--LfNKLvdl-asTNKDE---LIEE 223
XP_001383935 135 LTSFDSAVAEIISF---------SGDNSRLSQALDTLIDLSHDIEFGVKLTASRD--IfDSLlei-gqSHKDD---EITE 199
XP_002619758 194 LSDYASSVEELLHFGk-------NADVSRLEKALDTLIDLSHDIDFGERLTRDPK--VfSSLldaaqlTSSES---QIPE 261
Q6BTV5       140 LNDFQSSVDEVQHYRe-------GGDANRLSTALDTLIDLSHDIEFGVKLTQDSS--VfRSLvdv-skSVQDE---DLQE 206 Debaryomyces ha...
CCE64460     316 LSTRAITGCLRNNPPVLEFICVNH--K----EFPSELFQWLSTLqdksidvlNLYKTLIKRYISILDEILSSMpiydmnT 389
XP_004197374 221 RAYQIMASSLRNNPDASNNLLENQk-P----EFVEHLFEEVSE---------RKSGVTRKRVLGIIQGLAQNKyf--asK 284
XP_007373452 199 QIYRIIGASLRNNPEAIRNLLDDVd-D----VYIRDLFKQL-H---------DSKDVIQKRVLGIIQALAQDSsf--akQ 261
Q5A360       202 KVYRVMGSSLRNNPEAISNILTNFd-K----SYVDNLFEQL-A---------NENDVLQKRILGIIQALVQNShf--vrQ 264 Candida albican...
EER32665     219 KAYRIMGSSLRNNPEAINNLLSNFd-R----DFVTNLFSQL-S---------KKDDVLQKRILGIIQALSQNGhf--trE 281
XP_001525130 252 KVYNIIASSLRNNPEAVQNIIDGRs-GidytAFTKSLLGQL-E---------LASDLVQKRILGIVQALTQNVqf--veS 318
CCE45203     224 KIYNIITASLRNNPGAITNLLNGKvsGfnvaNFINSLLDDI-S---------QSPDTIQKRKIGIIQALAQDPsv--aqQ 291
XP_001383935 200 KVYRIMGASLRNNPDSVTNLLRNSd-G----SFVAALFSNL-S---------TQKDVIQKRILGIIQGLAQNShf--ayE 262
XP_002619758 262 KSFRIMGSSLRNNPAAVTNVFEKQd-D----NFMVTLFATLESP--------ETSDVVRKRIAGVIHALASDMaf--ayQ 326
Q6BTV5       207 KVYRIMGSSLRNNPDAVNHVLKNQd-A----TFVECLFDKLDT---------DASDVIKKRILGIIHALTQNShf--naK 270 Debaryomyces ha...
CCE64460     390 T----------DLESLTVIYeSLDDPKIKTKVLELVSRFFSKHIEvitiesgdepSIKKRNEQVVQDVQKWTDELATSIQ 459
XP_004197374 285 Ylswn--skdsKIKVLINSF-TSMSPESQSRVINIFEDLGMLDhd---------eVEKRSTL-------EPRAIFSNILQ 345
XP_007373452 262 Yftfd---hsyGLDDIVDIF-PSLGPESRIRAANILEDLQLHDtt----------eTKR--EE-Q----VPEQQFSSFIQ 320
Q5A360       265 Yfsfd---hssGLNDLIAIF-PKLGPNSKSRASNILEDLQLFPvt----------nDRRSLED-Q----DPESQVSKFIQ 325 Candida albican...
EER32665     282 Yfsfd---hssGLDNLIEIF-PNLGVESQTRASNILEDLQLFPvt----------nDRRSLED-Q----DPESRVSKFIQ 342
XP_001525130 319 Fftfaq-ghnyGLNTLVENF-TKLGPQAKTRAANILQDLDLVGks----------nDRRSLED-D----DPSSNVSNFIQ 381
CCE45203     292 Yfsye---hpnGLNQLIKVY-PTLSLDAKIRVVHLLEDLNLWqn----------nKEKRSDEDEEETETDPDSNLSQFIQ 357
XP_001383935 263 Yfshn---knhGISNLISVY-PQLGPDSRERCVNILEDLNLLSrd---------dFDRRAVEEFN----NADLQISRFLQ 325
XP_002619758 327 FfnvedaskslGFSRLLRIF-PKADHETQERIAMLFEDLNLLPs----------sPDKRD-EDSP----KPQERVSEMLQ 390
Q6BTV5       271 Yfnsn--nansAVDSLISVF-PSLESQSQTRLMNILEDLKLLGGAns--------nEKRAIEESA----DPKSQYSHFLQ 335 Debaryomyces ha...
CCE64460     460 -----DKNNDEMHIRKFFNGLYQIKSHfKNDIKVDNSFLNWLAKETELRKPN-KEKSEEKDSDQDYFDSLLVSSRHLIFG 533
XP_004197374 346 krlyqNQASDENEFRLLFQKLKEVHTE-NKDVKPSNKFIEWLADETEAR-KSkKKRE-EISDQDAEYNRDFIIDAHEIFG 422
XP_007373452 321 kslieNKVIAD-QMKTYFTKLVELHKE-TPSLQPSKDFISWLAQEVELR-KEnTKRD-DYSQHEKDFDREMLIARHEVFG 396
Q5A360       326 nsfvgNKLDEK-NFKSYFDQLVNLHQS-NKSLRPSGDFLNWLAEEVESR-KEnKKRD-DYSQEDKDFDEYMLRARHEVFG 401 Candida albican...
EER32665     343 nsfvgNKLDQD-NFKQYFNQLAKLHQD-NKDLKPTNEFIEWLAKEAELR-KEnKKRD-DYSQDDKNFDEFMLTARHEIFG 418
XP_001525130 382 halveNKVSTQSEFEKYFDNLVTIHQQ-DETLKPTREFLNWLAREVEVR-KEkKKRD-DVSLEELKFDEEMLHARHEVFG 458
CCE45203     358 qslarNKFGNENDANAYFSHLAELHKS-DKSLKPSSDFLQWLSKEVELR-KDrKKRN-DVSQQDLDFDRFMLEARHEIFG 434
XP_001383935 326 eslssNEITSPIQFRTYFDNLVTLHER-NKELKPTSDFLKWLATEVETR-KSyKKRE-DYPQQEKDYDEKMLHARHVVFG 402
XP_002619758 391 tlvpaSQ--SEEQLQNMFKSLVELHR--NHDLRPSKQFLQWLSKETEMRKNTkNVRD----KTDADFDTFMLEARHLVFG 462
Q6BTV5       336 hsladSGVASEDQFKLYFNKLSEVHSQ-DKSLKPSKAFMEWLSKEAELRSKGnKERDSSYTEEDRQFDQDLLRARHVVFG 414 Debaryomyces ha...
CCE64460     534 NELAHNlK----HD 543
XP_004197374 423 NPKAAR-KaladYD 435
XP_007373452 397 NPMGLR-Ka--fAD 407
Q5A360       402 NPMGLR-Ka--iAD 412 Candida albicans SC5314
EER32665     419 NPMGLR-Ka--iAD 429
XP_001525130 459 NPMGLR-Ka--iAD 469
CCE45203     435 NPMGLR-Ka--tAD 445
XP_001383935 403 NPLGLR-Ka--iAD 413
XP_002619758 463 NPNALR-K----AD 471
Q6BTV5       415 NPMGLR-Ka--lAD 425 Debaryomyces hansenii CBS767
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