Conserved Protein Domain Family
DUF4868

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pfam16162: DUF4868 
Domain of unknown function (DUF4868)
This family consists of uncharacterized proteins around 320 residues in length and is a phylogenetically broad range of bacteria associated with the human gut microbiome. A member of this family from Lactobacillus casei CRL 705 is part of the gene cluster involved in synthesis of bacteriocin toxin, but the specific function of this family is unknown.
Statistics
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PSSM-Id: 406549
Aligned: 13 rows
Threshold Bit Score: 121.615
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q24LC1                      115 KLNFYCLNIKFEENnq----eKEINFFRRVTKFKKLsskgFMGFIKNNRF-KKLDSNLLGLDGFIDIAIY---------- 179 ...
WP_015008941                114 KKDIYCIRIEIDSG-------EYVYFLNRIPQLRKFek-gIWGRLVDSTF-KKTTNAFIGIEPNFDLIIY---------- 174 ...
jgi:Mpal_0631               112 LEQVWGYVVRIECFtktlflfKKYTPNKLLVKGKKL------LRMQDGQF-TNLNTQIITIDSSYDAVLLiessteisqk 184
Q60CS6                      115 LLNSWAYVIQIEQGneklfawRKISTLTQPKKVESR----RATFFVEHKLiDVEDKEVFLIDPRFDFFVH---------- 180 ...
WP_015851290                109 LQNTKYYCVKFKIKsgfihafKWIGATWSTKNTSY-----ASMFINEGSLkQLEEDHSFRVTKNFDVIVM---------- 173 ...
Q8EHX7                      107 LKGAKGYVVKFTSNgttvyavKRSTSTWKTSYPKKY----INMIFSNGEL-SGVEDNSFAIEKNFDFYVI---------- 171 ...
wucgs:EUBREC_0167           113 IGNVLGFLFKINLNskklfiyQQAYVGSRLQAKNN-----LRIIQKDNVF-EIVDKEMLKIDKRGELLIL---------- 176
WP_022202851                134 RDKADAILFRFRRGlhsiwayQYILPATIPNKKNQHffarILDTEQTDCF-VEMPEQLFVITRKVDLLII---------- 202 ...
jgi:Desgi_1063              120 RDNALGLLFMFRRGdnkiwgyQHIYTVTIPNKLRKN----WLSIQQAETF-KEMILPLFPIAKKVNLIII---------- 184
CBK98028                    111 RNKLSGFLFKINLNdqyfwvyQHIYSISRIDRSKN-----VIALFIGDTY-DEVDSDIVQIDSRADIIIF---------- 174
Q888D6                      121 LEKVKGMVIKLTDGntnlylyQHKFPIALHRKSK------LSFMSTQRNIlKRVGHDVIDINKNIDFFMY---------- 184 ...
jgi:Mmol_0225               115 IGNIKALLIEIGNNekqvilyKTIAPIHIFSQSS------FCLVQHETRL-EKIDKDFLRISPGFQMLKI---------- 177
WGS:ACWZ:HMPREF0669_01900.1 111 LSNIDFFLFLIGDEtnqillyKQLASINIYKKNTG-----IFVRKADNEF-ARVNDDFLRIVPGFEMFKI---------- 174
Q24LC1                      180 --GQDVLIFNHISLERIFSIADQYLEKAQNTIDIIRDINRID------NFEQFEE-DCLNDRRITRTLTKMLSEEARLen 250 ...
WP_015008941                175 --QEEILVVNNVAMQRIFDLRTKYIENANSVLSSFEDSEKIE------GFEQFKM-DSIEDGNVVKRVSRLMEKPERMtr 245 ...
jgi:Mpal_0631               185 ipSSDVFVLSRASFESFFSFVEIYKSEVEANKKYLIEKSLLN------NVTLLIE-NCINDGRKIRKLARIIKND----- 252
Q60CS6                      181 --DGTVFIANKREFETSMNFREGMKAKAAEVIQNFTDSGHFR------HVDLIQKyVG-DNLHHLRKMASILKAGY---- 247 ...
WP_015851290                174 --DNIEYIINFNPYSQIFDYKENLLEVADSAYTELIDLGVLT------SSEKIKKyVG-NNSMRLKRLSEVVAKGF---- 240 ...
Q8EHX7                      172 --NNTVFIANKRGFESAMQHRAAYVQAFTQLQQSPAFSGLFS------DINPIIEyVG-TNSIQLRRMAVIEEKGI---- 238 ...
wucgs:EUBREC_0167           177 --DNTILVRNVKVLQDFFGFQVFVRNQAQSVISKLEELDIIG------NIATLKEyQTGEKLTISKKLMKVKNSPVLA-- 246
WP_022202851                203 --GDTIVTKDIGLMQRHFGFNDFIKASAKKAVSDISDIRLVI------NCEKLTAyIERNQTKYSRKMMRIKHYHVVE-- 272 ...
jgi:Desgi_1063              185 --GQEITTKDISLMQRQFGFETYIRNSAQTVIGDVSEIGLFE------NIEKLSSyVERSKLTYAKKMMRIRHSAVLR-- 254
CBK98028                    175 --SSSAVTAKMDLMQRFFGFEQYIRAGAQKTIEIIRNLDIVD------SLEKFVAfENKSKLTNAKKLLKAKNSPVLQ-- 244
Q888D6                      185 --NGVHYIVNVKRLEASYGLDAVINNMVNQVIPLIVSLNVIDmsahanPLEIFDDlKK--NKSSMRKIAKILNGRILSv- 259 ...
jgi:Mmol_0225               178 --DGELLVNDLAALERSFGFHEIIKKEATLGITAIEDKLVIE------NVEALRElLE--DIKYARRFVKVAKGSPVLik 247
WGS:ACWZ:HMPREF0669_01900.1 175 --NEELYILDLKFLERKFKIYDVIRSAAVKEIEKINEYGIVQ------NAESLNNlLK--DTSFARKLSKISEHSPVLg- 243
Q24LC1                      251 cFDNFANVVNAIDLFq-lDINIDRNgeRDKVIYENKEQLMDIIRLVRDSYYKSII 304 Clostridium virus phiCD119
WP_015008941                246 fIDNFDKVEQIIIEF---DLNIELNaeKTKIKYTDKKQLNDIVKLLNDAYYKTVL 297 Amphibacillus xylanus
jgi:Mpal_0631               253 -QLQSITIEKIKKMVqdyNLDIYFDa-TGKIEFTPEK-IWVFLRIFDDDYVKSEI 304
Q60CS6                      248 -YQQPDYIQRLIEVSkeeGWALKVE--NGQIVVEEDS-IELLLKLLNNDRLRSPI 298 Methylococcus capsulatus
WP_015851290                241 -YAQEKFMKNLKANNkelKFNFKFV--GDKIEPEENK-ISELLTALGDRRLTS-M 290 Maridesulfovibrio salexigens
Q8EHX7                      239 -YSRPNFIPTLQRVNntrNWGINFDpiSNTIIPCVST-AGIIINVLLDHRLISEI 291 Shewanella oneidensis
wucgs:EUBREC_0167           247 -MDKDELINKIPLVPr-yKNIIHIE--NGKIRTNTKKDVDNLMKLLNDDYVKSEL 297
WP_022202851                273 -KTAEELIQRVNTVPr-wQGVFDIR--GGQIYLHTFRDVENLIDLFDERYTVSLV 323 Enterocloster clostridiof...
jgi:Desgi_1063              255 -MSSEQLLNKVQTLPr-wSGKFVIE--NNRIVLKTYNHVENLIDLLDERYTRSDV 305
CBK98028                    245 -MKKNDLLENLKKHSr-yKTMFKFE--EDHIVISSQKEAAAFIKMLNDDIVRSEL 295
Q888D6                      260 gLTIPQIINVCNDFPv-fSRGITFS--NNFVDLSSQKKKLIFIRMLNDEAVRSAL 311 Pseudomonas syringae pv. ...
jgi:Mmol_0225               248 nIPNTSIISFCKTFPa-lAGRIRFNqaEDKIVLDSKVSKDLFIKLLMDNFLTSDL 301
WGS:ACWZ:HMPREF0669_01900.1 244 kVSNNAIISFTKNYPs-lKNTFKYTddDSQIILTTQKSMMTFIKLLNDDFLSSEL 297
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