Conserved Protein Domain Family
Fuseless

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pfam15993: Fuseless 
Fuseless
This family includes Drosophila fuseless protein and contains four WXGXW motifs. Fuseless is a transmembrane protein which regulates pre-synaptic calcium channels.
Statistics
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PSSM-Id: 406404
Aligned: 18 rows
Threshold Bit Score: 281.083
Created: 26-Mar-2022
Updated: 13-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEN61157     373 IHRVGHFIFVSAVITPSVLLFWRGSFNLLEQYL-P--GEESARPWLALAIGSPVVLLAGLLQHHIARLarwTRGKSYFLY 449
XP_009029410   6 KYSLFDALINWFLFTPLVVAFWCGTYGLIDILLfDliDSRQLATIFVLLFGVSIEFTITYWQDKISEF---ARELTGIKF 82 
EEN61158      61 RLKISDFLVIAVVITPAVNLFWRGTWNLLEESL-P--GDAGSRAWLSLAIGSPVLLLAGLLQHPLRRLgvrVQGKSMLGY 137
XP_002602953   3 ILRWLDFLIILLLIGPLTVAYWRGTWSLMNVYLfP--NDDVISAWTSFAIGTSVSLILNFAQGNLQNKf-aRRN---VVF 76 
EEN54254      25 LIQVLDAIILLVIIAALLLACWAGLWKVMDILLfP--KDKELAGWTCLAIGMTLQLILNFFQKIFYDT---TRNVNPILY 99 
Q7K3S3        73 LLELLDMMMSCLVVAPCVIAYWRGTWELMFVYLfP--GSLPLSAMASFLIGGLGHFFFTVTQNFFKEHi-hPDR-RRLTY 148 fruit fly
2_pfamImport   1 LLTFLDKFLSISIITPLVVAYWRGTWRGTDVLVyS--DDGKKSAMVSMLIGTLGSLLFTLCQSQIMNKi-hSHI-NPVKY 76 
XP_011147071  44 ILTILDTVFSALVAAPAVVGYWRGTWGLSDLYVyP--DEPIFSSFASIAIGFAGLFAFSVLQHGLDDAl-hPDK-HRLSY 119
ESO07620      16 GLMIADVFISTLIIFPLTVLHWDGTWVLQDEYFfP--DNEQISTLLSFTLGATICMFQLLMQPQLAEWi-tTDT--PAIY 90 
XP_011449730  16 fLAVGDTLIGVVILPNFVASYWMGTWLIYDFYLyP--DDIRLSAWICYAVGNVCVLICILSQHILRSWfipKDGKRTWGF 93 
EEN61157     450 RLFVGAYFYVVAFAVVSQWVALWDLpvylipqMDNA---KGQG------IRAVLAFVIMIFLRTVGQGRACPVDASFDCD 520
XP_009029410  83 AFFSRGYNYVLATANICHYRAIQEV-------YDSI---FGPEnfgacvQTAVTSIVLLWSLRAGRNITALPFCVSLDSE 152
EEN61158     138 HVLGMLYSYVIAFASVSQWRGFWNLpnyyipqMDTP---SGYG------LRTLLGFVAMVILRTVLLGGGCPRSVSVDFD 208
XP_002602953  77 HVLFRVYIYVFGLAVVNHWRGCWYI-------LDKY---TNMTvls-avISVIVPIPILLVLRACGNLVAAPGVILVDIS 145
EEN54254     100 GFLWRLHAYVGLIAALTLWRGVWTC-------FEFY---TGESals-laVSAIIAGVILIPLRLFNVIVTVPGRMVKEPA 168
Q7K3S3       149 YAVSRLYTAVFGIVCVNMWRGAWLL-------CDWL---TSVDsliivsVVTAIALIFLVATRTLRNLGAAPYTVTMDHK 218 fruit fly
2_pfamImport  77 YLITRLYTASFGIVCVNQFRGAWMF-------LDLH---TSCDvvt-vtIITVSSIFILFITKTLRNLSAPPFAVTIDRY 145
XP_011147071 120 YLGSRLYTGVFGFCCVNAWRGAWKG-------LDIY---TDHTast-vfATTAVSLLALGIMRAIRNISAPPFALCLDSC 188
ESO07620      91 ILVTRIHFYIHGWAILCYWRGTWNL-------LDFMfnnANPKfiyviiIIYVICQLLMILTRTVRSAVGAPVALRLDTS 163
XP_011449730  94 LIALHVYKYVMALIGVMQWRGLAYV-------AVLY---TGMTlts-avVGLIGATILLALLRNHIGILTPPLTMALDPD 162
EEN61157     521 -PEPFRIPLRFRTDraercsgKFVLDVVFSLFVIDLITVQNWAGTWSLLDYTVL-----PDDPCLSSWVSLGVGYTLLLL 594
XP_009029410 153 tENWFSAPTLYQRY-------SYLCDVIITVMCVWSLAPLHWITFGYFLDHVIF-----PDFPELSSAVSCLLGYTVVAV 220
EEN61158     209 -PDPFRVDLRFHTNkaerfswRFVLDVMFSLWACDFATVQYWAGLWGFLDVVLF-----PDNPCFSYWLSVGIGYGVYVL 282
XP_002602953 146 -DTPFKVGTRFAAEvsi--swTFIGDVALTVIFIGSLIVGSWRGIWLLFDIFLF-----PTDKKNSALSSVGIGYGTLFL 217
EEN54254     169 -ADPFKIPTRFQIApsc--scKFVLDVLFNVIVISVLFVVYFRGVFDLMEKVVY-----PGDKVRNLWACMMIGYGVLVP 240
Q7K3S3       219 -SDYFEVDTMFKIPgfh-qpgLYILDTLFSVFVIGSLVVIAWRGVWGIFDLLLF-----PADKAKSAWGSLLIGYLTVFV 291 fruit fly
2_pfamImport 146 -EDYFTVPTFFKYSsdk--twLYLFDCIFSVCVIGTLVVFVWRGTWTLVDLLLW-----PNNAVMSACASAMIGYTLVVL 217
XP_011147071 189 -PGYFEVQTMFRVNntr-dwsLYLLDCAFSVGVVGTLVVFVWRGVWILFDIYLF-----PENEEYSAVGSLAIGYSIVAV 261
ESO07620     164 -NDLLEADVVFKTShdn--fvKFALDCLFTQFVVVTISITIWWALWWLFDITLF-----KDPSTDPI--CCLVGFIISIS 233
XP_011449730 163 vVDSFTIPTKFSCEpgl--swKFLLDTLFTVFVVTTFAGFALKGYWILLELGMPvdesdPIDLMDKGLVSLLIFYGLVSI 240
EEN61157     595 LTAIQFPLYTASKRLRGerlDFYKRLAIEDTFGLVVNFAVNNVWRGLWGLYD-------CHILp-dRPWESFWLTHGVGA 666
XP_009029410 221 FSYYQYEIRNWSKYYDNe-kRMITKTFLENFFIWGATAGVIATWKGLGMAIDmtskahpIYLN---DVNISSLCLNVISF 296
EEN61158     283 ATFAQYPVSALSKHLQGtdkEFWKRLALEDAYLLIVNSGVVNIWRGVWSVYD-------CYILp-eQPKLSAWLTHGGGA 354
XP_002602953 218 LVLLEAPVSNLLRQTRK----LSARILMEDAFKLAAWVGVLNVWRGFWLVCD-------SYILp-dNPVQSYWITHGVGI 285
EEN54254     241 CVVAQRYVAMLYRALAD---RLWLRIALDDTYSFVIAFGVVNVWRGWWEFYD-------VYLLatgDQVLRGALLHLAGV 310
Q7K3S3       292 TFLIHPLMRYVCRRISG-----ILKLIICDIYYLMTFFGAVNAWRGIWNLLD-------VYLYp-dNKLLSFWLTHIVPF 358 fruit fly
2_pfamImport 218 TFCMQPFVKYLARTLSG-----VVRLIVVDIYLLFSFCGTVNVWRGIWNLLN-------HYFLp-dMANTSFLLTHLVSF 284
XP_011147071 262 TFCLQPLMRYVCARLQG-----LVRLVVADIFLLLSFLGTVNVWRGIWVALD-------LWLLp-dNPELSCWITHIGCF 328
ESO07620     234 LLLLQVPLSRISESLDG---RYWLKLAYEDTIFIILTWANVMFWRGFWNVWI-------NDFLp--KKTVGCWVSHVIGS 301
XP_011449730 241 PIIGQYELMKLNKKVEHk--HPYLVATIEEVFIAILGMLPMLFWRAVYLIHL-------SFVPp-eYYKVYLWTSHVIGF 310
EEN61157     667 AVCFMVCAGSS-M 678
XP_009029410 297 TLLSLCHVSAS-L 308
EEN61158     355 AVCFLVFAGRS-L 366
XP_002602953 286 GGLLLLQGGRSvL 298
EEN54254     311 LVSYLLYASRaqa 323
Q7K3S3       359 LLLAALKCSNSiL 371 fruit fly
2_pfamImport 285 LILMLINSSNSiL 297
XP_011147071 329 VFLVLLNCSNSiL 341
ESO07620     302 VGLLFLQGLNnvg 314
XP_011449730 311 IGACAMRASTS-M 322
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