Conserved Protein Domain Family
VIT_2
?
pfam13757: VIT_2 
Vault protein inter-alpha-trypsin domain
Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains. ITIs play a role in extracellular matrix (ECM) stabilization and tumour metastasis as well as in plasma protease inhibition. The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (pfam00092) in ITI heavy chains (ITIHs) and their precursors.
Links
?
Statistics
?
PSSM-Id: 404621
Aligned: 6 rows
Threshold Bit Score: 118.72
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
WGS:ABKH:PAAG_05817   16 WFLGPTSQRNLLPQVDLKVHSTILSASSRTTLTQTFINPTPGELKDVkYTFPLVDGVSAVEFTCEIGNRVIRGIVKERE 94  
Q5TIE3                 2 PGLLNWITGAALPLTASDVTSCVSGYALGLTASLTYGNLEAQPFQGL-FVYPLDECTTVIGFEAVIADRVVTVQIKDKA 79   human
Q8N398                 2 PGLYCPSSWTPLPLTDSWVRACANGPCLSVRARLTYRNPQPQPVDGV-FVYPLAEAEVVSGFEAEAAGRRVSFQLQSRR 79   human
XP_002601158           2 PGLINIHSRTRIPLQASRASACLIGYSLGLTASLTYYNDQDVPVDAM-FVYPVDESCVVVGFEALVGGRTISLQLKDGP 79  
EEN57173               2 PRLLNWATRTRVPLKSVRISACMMGHSLGMTSSFSYYNDQDYPLEVA-FIYPLDNKTTVVGFDAMIAGRTIGVQLREKK 79  
XP_001629587           2 TGLVNRHTSYPLQLKASSIFAEVNGFAARVLATLTYYNQCEYDVEGL-FVFPQDERTTVVELEATVEERHVYTDIRAQT 79
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap