Conserved Protein Domain Family
VSG_B

?
pfam13206: VSG_B 
Trypanosomal VSG domain
This family represents the B-type variant surface glycoproteins from trypanosomal parasites. This family is related to pfam00913.
Statistics
?
PSSM-Id: 404155
Aligned: 55 rows
Threshold Bit Score: 162.663
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q57U36   9 ISLLLAFHTAT---SGASDFLNEDEFVALCLMIKVTKNALRRIKEAR--EVTKDATRIGARCLQVAGLGILNKICENTDD 83  Trypanosoma brucei
Q4GZE7   8 TIVLLIPQPAL---SNSAADENRGPFTALCTLVNLAKQPPAQLQAPA--DIAATLETIAAINMTVADSTFMDKVdvnkd- 81  Trypanosoma brucei
Q38CQ0  12 TMAMVLRQQAQ---GAVKDNEHGGDCAALCGLIQFAEPNTPAISLPQ--EITEIADELLAVNLSMSEAALQQLVTKHKDK 86  Trypanosoma brucei
Q57UD7   6 VFLITARLQVY---GVISGGENQEDFEVLCELTALAKSKVNLVPAVD--DTQDIAATIGVINISLANADFISKIDLKKDY 80  Trypanosoma brucei
Q57VH5  12 LVWTQATKRSV---GKPTNIINQEEFKALCAFVNLANESVDYAGLEA--EIRDAAADIGAIFLASQQESISKLREQIEIW 86  Trypanosoma brucei
Q38EL6  16 PLIPRAALVAK-------GAENEGDFRALCGLINLASNSEDHAALLA--RVEDTAANIGAISLAVEYQSFSDLERATKDW 86  Trypanosoma brucei
Q4GY64   8 VAAAVVIIAAQ---INSVKIVNQEEFEILCGFVRLTLAPAPLIQLSQriKNEAVGAAVDAIYSEPNQEHLWKKLSPNcea 84  Trypanosoma brucei
Q38CT5   8 vvfLVAALQGIhlvSGQ-DIVNQKEFEALCRIVNWAEKGLKQITLAR--QVTQEAQKIGVRYLEVVGEENAAELAKTQED 84  Trypanosoma brucei
Q38CU3   8 vvFLVAALQGIhlvLGQEEILNEQEFEALCRMINWAERGLKHINLAR--QVTEEALKIGVRYLEVAGEEEVTELTELQEK 85  Trypanosoma brucei
Q38CT8   4 vVVLLTVLHSChraLGKEDIVNQKEFEALCRMINWAEERLEHIKVTK--RVTQEALKIGVRYLEVAGEEECRHIAKAQED 81  Trypanosoma brucei
Q57U36  84 -------------ETCGRRRAFWDAAKDLVNRRHGGvsmrgadseaedeeeegsesadpeesdweetdeeeshskeedRk 150 Trypanosoma brucei
Q4GZE7  82 --------yatadQPFRDARPGWEKNYALFSKAKRK-------------------------------------------- 109 Trypanosoma brucei
Q38CQ0  87 swddipasdkpaaQPYKEHWQHWQKLAADPKPETVK------------------------------------------F- 123 Trypanosoma brucei
Q57UD7  81 sdsnas--mkeaaDGKPSKYAFLKNVLEVSHGQDKK-------------------------------------------- 114 Trypanosoma brucei
Q57VH5  87 reveat--nnggnNRGIKKWSVWEEARRKLIDEGGT-------------------------------------------- 120 Trypanosoma brucei
Q38EL6  87 eeiadd--rkhshETNEGHRKFWTGARSKLGGPEKD-------------------------------------------- 120 Trypanosoma brucei
Q4GY64  85 hq------isdreSVCDAYARFKHEAEERLKTSRLT------------------------------------------E- 115 Trypanosoma brucei
Q38CT5  85 scayk---revggRNCVLYKTFWQHAQEALKGTARS-------------------------------------------- 117 Trypanosoma brucei
Q38CU3  86 acmsnk--ktsheKNCGLYKTFWEESQEALKRTARS-------------------------------------------- 119 Trypanosoma brucei
Q38CT8  82 sctkk---medrkRNCGLYKNFWEEAQKAVKERAFS------------------------------------------G- 115 Trypanosoma brucei
Q57U36 151 shsheekqkihpkeedqkphskeevqeearrEETISTNTRLDHRtlekVQQIAGTAAQVYVDITKTPWVPH-----SGDL 225 Trypanosoma brucei
Q4GZE7 110 -------------------------------ATGDEKAKFASWAakkgIPNLKQQVIKLAEAAQKIGADAEa---aASRL 155 Trypanosoma brucei
Q38CQ0 124 -------------------------------KLEQFRKVSQNTMaknkFHLIADAALELATEAKMLLQKKT-----KTDI 167 Trypanosoma brucei
Q57UD7 115 -------------------------------SYAEVRRRQLTTAakrkLIQAAEVAFQISETAKNEAQQIK-----AEAV 158 Trypanosoma brucei
Q57VH5 121 -------------------------------KYVQWVELGLSDAekqkIEEAMDETVKCMAEENGLWDTLR-----EMPV 164 Trypanosoma brucei
Q38EL6 121 -------------------------------KYAVWTGSALSKEdkrkVANAAERAEDCMKDNDGLWRILK-----ETSI 164 Trypanosoma brucei
Q4GY64 116 -------------------------------------------------PELTDYSPDVLDHLEKAFKLYQaseleGKQT 146 Trypanosoma brucei
Q38CT5 118 -------------------------------SVHHRAMNTLEYHtiekIKEKAMHGADIYHDVGAESLSVK-----VEKI 161 Trypanosoma brucei
Q38CU3 120 -------------------------------QAPHRGRNSLQYHtaegIKIKVMEVADTYHEVKKEILKLR-----TDNM 163 Trypanosoma brucei
Q38CT8 116 -------------------------------EKLERKIDALGEHtvdeIKKKGMYGADIYHDVEAKRPSGN-----MRKM 159 Trypanosoma brucei
Q57U36 226 E-----RKIYQALYGVPREP----EEIREGTASRDGVCRQkatRSAVNNPPATLSRDLlCMCATDv-ESREKTKLCCQNC 295 Trypanosoma brucei
Q4GZE7 156 AtgkveELLNKALYGTAAPTdtsyKLATDTADNRAKLCSQk-gGKGKSIPGKSLVHDLiCLCARGpnSDASQGKACCGDC 234 Trypanosoma brucei
Q38CQ0 168 D-----TKLTKALNGNNAPT----NTFTFSGKTRSQLCGTg-tTTPGEQAGKALLVDLlCICAGAn-TDTTAGKSCCKGC 236 Trypanosoma brucei
Q57UD7 159 T-----AALTKALYGETGNS----KNARLPDTNRASGCGNs-nKKGGSHAGNSIALDIlCLCGKHs-GEARGNTACGKQL 227 Trypanosoma brucei
Q57VH5 165 K-----GSITKAIFGSRERQ----VQIMKGRGSRETACGRg--LFPGDWAGTALSADLlCLCAATe-RRAATNEGCCTGC 232 Trypanosoma brucei
Q38EL6 165 E-----KNLIEALYGSGQQN----GEVMRGTYGRKDVCGRg--IFAGSLAGLALSIDLlCLCGASg-SAVESDQGCCAEC 232 Trypanosoma brucei
Q4GY64 147 SivtlqEGINSIMYGENDSG----GNSLWGDHFRNEDCGTv-lGQRPKYAGGALVTDLlCLCAQHv-NGSDTKHLCCEGC 220 Trypanosoma brucei
Q38CT5 162 E-----RKINQALYGMEYFT----EEIKPGG-DRSRVCGQs-sRSEMIIGGNSLAVDFlCLCAMH--SSWNGIKVCCTDC 228 Trypanosoma brucei
Q38CU3 164 E-----EQLNQALYGVGHFT----GEVKGGDSDRSRVCGQn-lGNRDATGGWSLAVDLlCLCARHi-SWSSVKSVCCEEC 232 Trypanosoma brucei
Q38CT8 160 E-----EHLIKALYGMEYFS----EDIKGGDSDRSRVCGQn-lRNNKATGGWSLAVDLlCLCATHn-SWKGRKKVCCADC 228 Trypanosoma brucei
Q57U36 296 vagPNLAVWKPNR-----------DSWERWNYLRAQC----AVVRdLQIGFKEMVKKFTHKFGHRHDNSIgte--lyMGF 358 Trypanosoma brucei
Q4GZE7 235 ------------DgnlatevavnsDAKTQIDALTKACsklgSPTElTRATLTGAVAALANQLQHKTATQSsen--nvLGT 300 Trypanosoma brucei
Q38CQ0 237 etnPNHDEWQPAT-----------NAKLRAEHIAKQCpttrATADkSTTKLHHLLGDFYTQVNTAKGTGQemk--yaLGT 303 Trypanosoma brucei
Q57UD7 228 trgELDNDWTPNA-----------DPTTLFNAIIEKCntkkPSLGlSPAAINAALSRFAARMAKSKGTNRdfh--ntLGY 294 Trypanosoma brucei
Q57VH5 233 etgGNGVAWDPRV-----------HSEERWNLLRSKCekvsSGTPlSSRALSVAESTFFNQLKISKGSTSgrp--tlLGK 299 Trypanosoma brucei
Q38EL6 233 ekgGNSDTWIPSQ-----------AGEERWGYLKHQCekigSNAElSRKSLSDAMNLLLKRLRP-SSTRGmdl--tvLGK 298 Trypanosoma brucei
Q4GY64 221 swrSNTTVWSEEG-----------GLKLQWEILREKCigynMDLAnPKDRLKRLREEMECRTVPRGIGSRkglfvytYGE 289 Trypanosoma brucei
Q38CT5 229 ttgENSNEWDPES-----------NGVQRWKFLKQKCadhnPNYYdTEKRLRNAKQNFMDTVTTIHGRGGrtl--ykLGK 295 Trypanosoma brucei
Q38CU3 233 gtgENSNTWNPAL-----------DGALHWEFLKENCpgdnTNHHtEGEQLKSAKKNFMAKVSKIATIPYrtm--ykLGD 299 Trypanosoma brucei
Q38CT8 229 stgENRDEWNPES-----------NEAPRWDFLKQKCagrhRNRHdMIEKLSEAEENLMKTVTKIGTIPYtht--yvLGT 295 Trypanosoma brucei
Q57U36 359 TTRyhmwplslfhkPV---------PGPGVVYVLMGDRRGDEDVPWVRLLEQVTKEMGGLPLGVGEEKQYAETLE 424 Trypanosoma brucei
Q4GZE7 301 MHSdg--------sAGctgn-aasnGGKCVVYKDGLTSSGDNAVQWLKHLQEAISEEARRHAASQKLQTLATQIK 366 Trypanosoma brucei
Q38CQ0 304 VGGng--------nDGctgkvgstnNGRCVKYTDNSILKGTPQLDWVQNLIDAAADYDARTDNMNKIQRIADKME 370 Trypanosoma brucei
Q57UD7 295 LEGtg--------aGGcsgd-atstHGPCVAYQTAQLQNGLQGIPWVKELTSAGSTLQEAEKHQHTLKLLNQRIH 360 Trypanosoma brucei
Q57VH5 300 FGTsf--------sVGctge-itekEGRCVRYSHSHVDRNNPALPWLTNLREAANAVDQ-------LNAVDTKLK 358 Trypanosoma brucei
Q38EL6 299 FEGnl--------aTGctgi-iktgQGRCVQYSVSNVKRNNPTLPWLEKMKAAADAIDQLSAIDARLSELEDEIm 364 Trypanosoma brucei
Q4GY64 290 LEKre--------lVScgge-drqdSGACVLYEWGGTQIQTARIPWMQRLEKLVDMLPNVSEESDRMEKRRRQIE 355 Trypanosoma brucei
Q38CT5 296 KQSse--------vNNcgag-tgrgQGICVLYKGHGEE-----LPWMKALVEVENEMEVLLQDKHNKSAKLERIK 356 Trypanosoma brucei
Q38CU3 300 SKNiq--------tKQcgan-igtgQGICVYYGSDNGAN----LHWMQALERVENDVEVLLQDSKYKSTKLKRIK 361 Trypanosoma brucei
Q38CT8 296 AVNsr--------iKPcgad-inkqQEICVHYGSDNGTK----LPWLKALQKVEKEMKLTLKDKQDKSAKLKRME 357 Trypanosoma brucei
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap