Conserved Protein Domain Family
GHBP

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pfam12772: GHBP 
Growth hormone receptor binding
Growth hormone receptor binding protein is produced either by proteolysis of the GHR (growth hormone receptor) at the cell surface thereby releasing its extracellular domain, the GHBP (growth hormone-binding protein), or, in rodents, by alternative processing of the GHR transcript. The sheddase proteolytic enzyme responsible for the cleavage is TACE (tumor necrosis factor-alpha-converting enzyme). Growth hormone (GH) binding to GH receptor (GHR) is the initial step that leads to the physiological functions of the hormone. The biological effects of GHBP are determined by the serum levels of growth hormone (GH), which can vary. Low levels of GH can result in a dwarf phenotype and have been positively correlated with an increased life expectancy. High levels of GH can lead to gigantism or a clinical syndrome termed acromegaly and have been implicated in diabetic eye and kidney damage.
Statistics
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PSSM-Id: 403851
View PSSM: pfam12772
Aligned: 11 rows
Threshold Bit Score: 302.555
Threshold Setting Gi: 525342595
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008101044 291 KGKLDEVNSILASHG-----SYMPQLYGEDSWVEFIELDI-E--ENEER--TEGSDTDRLLG-------DDHLKTHGCLA 353 green anole
XP_015128166 289 KGKLDEVNSILASHD-----NYKTQLYNDDLWVEFIELDI-D--DSDEK--NRVSDTDRLLS-------DDHLKSHSCLG 351 chicken
XP_005060638 292 KGKLDEVNSILACHD-----IYKTQLYSDDLWVEFIELDI-E--DPDEK--NRASDTDRLLS-------EDDLKSHNCLG 354 Collared flycat...
XP_019666893 316 EGKLEEVNTILAIHD-----NYKPEFYNDDSWVEFIELDI-D--DPDEK--TEGSDTDRLLS-------NDHEKSLNILG 378 domestic cat
Q3UP14       325 EGKLEEVNTILGIHD-----NYKPDFYNDDSWVEFIELDI-DeaDVDEK--TEGSDTDRLLS-------NDHEKSAGILG 389 house mouse
XP_003759961 323 KGKLEEVNTILASHD-----GYKPQFYNDDSWVEFIELDM-E--DPEEK--TQESDTDRLLR-------SDPPKSLHYLG 385 Tasmanian devil
XP_007487298 314 KGKLEEVNTILASHD-----SYKPQFYNDDSWVEFIELDI-D--DPDEK--AEESDTDRLLS-------SERQKSLNYLG 376 gray short-tail...
XP_005794966 303 KGKLEELNFILNGGGvdglpAYATDFYQEEPWVEFIEVDE-EdaEGGDKedNYNSDTQRLIGl-----pHRNVEGFRAIS 376 southern platyfish
NP_001098560 303 KGKLEELNFILNGGSigglqTFSPDFYQDEPWVEFIEVDE-EdaDSREKedDQASDTQKLLGppqpisdHRTIRCSETIR 381 Japanese medaka
NP_001266530 304 KGKLDELNFMLSGRGmdglpIYAPDFYQDEPWVELMEVDEtEdvDNGEKkdNRGSDTQKLLGqsqpvsqHININCSNSVS 383 Nile tilapia
XP_028916111 323 KGKLEEVNMILASHN-----SYKPEFYNDDSWVEFIELDI-D--DSEEK--TEGSDTDRLLN-------DDHLKSLNCLG 385 platypus
XP_008101044 354 VRDDDSGRASCCEPDIPETDFSVSDTCDGTSDIDQSKKTsDKEKDLLCLEQKDSEKPSSSFDESpTQLSPDNPAKTQQPK 433 green anole
XP_015128166 352 AKDDDSGRASCYEPDIPETDFSASDTCDAISDIDQFKKVtEKEEDLLCLHRKDDVEALQSLANT-DTQQPHTSTQSESRE 430 chicken
XP_005060638 355 AKDDDSGRASCCEPDIPETDFSASDTCDATSDSDQFKKAaEKEEDLLCLDRQDNDESLPSLANT-DPQGRHRNTQSENSL 433 Collared flycat...
XP_019666893 379 AKDDDSGRTSCYEPDILETDFNASDMCDGTSEVAQPQRL-KGEVDLLCLDQK-NQNNSPSTDATpTTQQPSV-ILAKENK 455 domestic cat
Q3UP14       390 AKDDDSGRTSCYDPDILDTDFHTSDMCDGTLKFAQSQKL-NMEADLLCLDQK-NLKNLPY-DASlGSLHPSITQTVEENK 466 house mouse
XP_003759961 386 AKDDDSGRTSCCEPDILETDLSASDSCDGTSDVTQSHRM-RGKADLSFLEHK---SDGPSKGDSpTTLPANGTTLSEGSK 461 Tasmanian devil
XP_007487298 377 AKDDDSGRTSCYEPDILETDLSAPASCDSTSDIAHSQRL-PGTADLFCLEPK--NEASPS-----TTPPPSGGLLSEGGQ 448 gray short-tail...
XP_005794966 377 HPDDDSGRASCYDTDLP-----------------------EHLASLLPGQPEDNKTCLD----ApATEMGEK-------- 421 southern platyfish
NP_001098560 382 HPEEVFGHGSCYNADRPEEDSK------------------VQMDAPPPGQAGDKESSTEFAERTpALDRCRA-------- 435 Japanese medaka
NP_001266530 384 gPDAESSQATCYNTDLPEEETL------------------MLMATLLPGQPDEEETSLDTVERSsASETGER-------- 437 Nile tilapia
XP_028916111 386 AKDDDSGRTSCYEPDILEVDFSAIDISDLSSEVAQMPKA-KEEGDLLCLNRK-TDDAPPSDLSTpDSPEPHDPLSPVGTK 463 platypus
XP_008101044 434 AHASATDSNEMTSPPVQTQLSNQSSVANIDFYTQVSDITPGGSVVLSPGQKMKMAKIQSEAGKEpvtqcqPS-------- 505 green anole
XP_015128166 431 SWPPFADSTDSANPSVQTQLSNQNSLTNTDFYAQVSDITPAGSVVLSPGQKSKVGRAQCESCTE------QN-------- 496 chicken
XP_005060638 434 LWAPFGDSLESPRPSVHTQMSNQNSLTSTDFYAQVSDITPAGRVVLSPGQKSKLGRAQREGCTE------QN-------- 499 Collared flycat...
XP_019666893 456 PRPLLTSGTESTHQAAHTQLSNPSSLANIDFYAQVSDITPAGSVVLSPGQKNKAGISPCDMHPEavslcqAN-------- 527 domestic cat
Q3UP14       467 PQPLLSSETEATHQLASTPMSNPTSLANIDFYAQVSDITPAGGVVLSPGQKIKAGIAQGNTQREvatpcqEN-------- 538 house mouse
XP_003759961 462 PRPLVAGGTESAGPPGHSQPGNQSSLANIDFYAQVSDITPAGSVVLSPGQKNKAGTAQGDGHPEmasrcqAN-------- 533 Tasmanian devil
XP_007487298 449 PRPLLPNGMESSSLAVHAHLSNQSSLANIDFYAQVSDITPAGSVVLSPGQKSKAGISQCDGHREasp-crGN-------- 519 gray short-tail...
XP_005794966 422 -------------PLIQTQIGGPQTWINTDLYAQVSNVMPSGGVVLSPGQQPKIQENTSGSEREtqkggkQNedvegike 488 southern platyfish
NP_001098560 436 -------------PPVQTQTGTPQTWVNTDFYAQVSNVMPSGGVVLSPGQQLRTQESTPASEHGaqtkgkQRdesgdmdg 502 Japanese medaka
NP_001266530 438 -------------QLIQTQTRGPQTWVNTDFYAQVTNVMPTGGVVLSPGQQLRIQESISAAEKEtkkkrkESedseesee 504 Nile tilapia
XP_028916111 464 PRPLLIDGVESKIPPVHSQLSNHSSLANIDFYTQVSDITPAGSVVLSPG-RNKASRTQCDALPEstslglPN-------- 534 platypus
XP_008101044 506 ----------IAMD---SAYFCETDVKKCVIVPPHKEAEPEVQDQS---------------FSEGAYIVTESLTTSAVnp 557 green anole
XP_015128166 497 ----------FTMD---NAYFCEADVKKCIAVISQEEDEPRVQEQS---------------CNEDTYFTTESLTTTGIn- 547 chicken
XP_005060638 500 ----------FAVD---NTYFCEADVKKCIAVTSHEENEPRVQEQG---------------YNEDGYFTTESLTTTVAn- 550 Collared flycat...
XP_019666893 528 ----------FIMD---NAYFCEADAKKCIAVAPHVEAESRVEPNF---------------NQEDIYITTESLTTTAG-- 577 domestic cat
Q3UP14       539 ----------YSMN---SAYFCESDAKKCIAVAPRMEATSCIKPSF---------------NQEDIYITTESLTTTAQ-- 588 house mouse
XP_003759961 534 ----------FLLD---NTYFCEAEAKKCVSAAPRAEAEPRAEPSF---------------SQEDGYITTESLTTTAV-- 583 Tasmanian devil
XP_007487298 520 ----------FILD---NTYFCEADAKKCVSVAPHAEPEPRTEPRF---------------SPEDVYITTESLTTTAG-- 569 gray short-tail...
XP_005794966 489 qkrnepqfqlFVLVpegSGYTAENNTQQ--TSTPPSTSVPGVGYQTiqpqpmetkpaatgdTNESPYILPEPSQSQLF-- 564 southern platyfish
NP_001098560 503 qrqkepqfhlLVVDpegSGYTTESNCWQ--NSTPSNSPNPGAGYQTippppvdikpaasadANQLPYILPD--CPQLV-- 576 Japanese medaka
NP_001266530 505 rkqkepqfqlLVVDpegSAYSTESSIQQ-ISTPPPSSPMPGEGYHIihpqpveprpaatmeLNQSPYIIPD--SPQFF-- 579 Nile tilapia
XP_028916111 535 ----------PTTD---NAYFCEADVKKSIAAAPPKGAEPHVAPKC---------------PEEDVYFTTESLTTTSV-- 584 platypus
XP_008101044 558 vtAAEDEELPeSSEMPVADYTSIHVVQSPQGLVLSATSLPVP 599 green anole
XP_015128166 548 -lGASMAETP-SMEMPVPDYTSIHIVHSPQGLVLNATALPVP 587 chicken
XP_005060638 551 -fGASTAAAP-SSETPVADYTSIHIVQSPQGLVLNATALPLP 590 Collared flycatcher
XP_019666893 578 --QSGTAERApGSEMPVPDYTSIHIVQSPQGLVLNATALPLP 617 domestic cat
Q3UP14       589 --MSETADIApDAEMSVPDYTTVHTVQSPRGLILNATALPLP 628 house mouse
XP_003759961 584 --SPGSAGGPsNPEMPVPDYTSIHIVQSPQGLVLNANALPVP 623 Tasmanian devil
XP_007487298 570 --SSGIAGGPsGAEMPVPDYTSIHIVQSPQGLVLNATALPVP 609 gray short-tailed opossum
XP_005794966 565 --------------TPVADYTVVQELDTHRSLLLNPPPSQSP 592 southern platyfish
NP_001098560 577 --------------APVADYTVVQELDTHHSLLLDPTPIQSP 604 Japanese medaka
NP_001266530 580 --------------APVADYTVVQELDSHHSLLLNPPCHQTP 607 Nile tilapia
XP_028916111 585 --SSRMPAEAsNPDTPVPDYTSIHIIQSPQGLVLNATTLPVP 624 platypus
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