6TB4


Conserved Protein Domain Family
SAGA-Tad1

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pfam12767: SAGA-Tad1 
Transcriptional regulator of RNA polII, SAGA, subunit
The yeast SAGA complex is a multifunctional coactivator that regulates transcription by RNA polymerase II. It is formed of five major modular subunits and shows a high degree of structural conservation to human TFTC and STAGA. The complex can also be conceived of as consisting of two histone-fold-containing core subunits, and this family is one of these. As a family it is likely to carry binding regions for interactions with a number of the other components of the complex.
Statistics
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PSSM-Id: 403847
View PSSM: pfam12767
Aligned: 122 rows
Threshold Bit Score: 80.2165
Threshold Setting Gi: 634347061
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6TB4_A         62 RIEIEPLVVDFQRRLGK-NWGRYQIAVSLFLVGKLSRRELVDELDDILDr-----------nTVKMHNQLLLGNLAN--- 126 
KDE02672       66 RADLLSLKLKLADLLPPhLGQLYWTSLVEFMTGQINRDELQGVFERVLGkgkqg----eqdtALQLHNALLLSILYN--- 138  Microbotryum ...
XP_001729242   18 AVDPRAVKVRLFEKLGs-FADEYWQLLGALCTAAIDRAEFHNRVKAKLPs-----------eCVPLHNALVLSILAEans 85   Malassezia gl...
KIS68213       23 RADTLDLKQKLAVALGq-NGARYWQTLVQFLKGAIDRSEFEALAHKALKt-----------eHIHLHNALILGILYN--- 87   Ustilago mayd...
XP_007406983   24 RSDTLSIKQSLIQLINPqDGLHYWSSFTNFIKAKIDRREFEEEVSRILNtd----------qLVGLHNSLVLSILYN--- 90   Melampsora la...
XP_003331164   21 RADTLAIKQAIAEALSEdEGLAYWTSLVKFLTGKLDRTEFEVQTAYLLKse----------tLVGLHNALILSILYN--- 87   Puccinia gram...
OAV96244       21 RADTLAIKQAIADALSEdDGRAYWASLVKFLTGKLDRTEFEAQTARLLQse----------sLVGLHNALILSILYN--- 87   Puccinia trit...
Q54DW3         33 RIDLIPLKKQLDAVLKd-RSEDYWEWIRKYLCGRLSKRELDYYVTTNLNe-----------pNLHLHNTFFKAVIFN--- 97   Dictyostelium...
EFA77170      256 RIDLVPLKKQLNTLLAd-KTDQYWDYIKRFLQGKLSKRELDYFVLDYLTesntllsfflwisKVHVHNQFFKALIFN--- 331  Heterostelium...
EGG14439       30 RIDYIPLKKQLNNVLKd-KADMYWDTLKQFFTGRMTKRELDHFVLLYLTe-----------sHLKLHNAFIRALLQN--- 94   Cavenderia fa...
6TB4_A        127 -Slkesagdrvgsggfggsmfnkrvkdsrkssqyerlkrdilalpvrerr------------------------------ 175 
KDE02672      139 -Ttriavppstlrhsgfqvkrrlsapndppnngsasevdplrkklktlvmslgkrerreikalvptqtgvtataasttsa 217  Microbotryum ...
XP_001729242   86 gSsasaasgtgasvraltspiqprravlndstdesddeteppvdgrasrglkrlrhlyaglsdderkrldqlskqs---- 161  Malassezia gl...
KIS68213       88 -Asadvpgpssrasrritrilpdgttiteeeeeepsrkrlrnlvaglprkerlrlknldkagklganavgg--------- 157  Ustilago mayd...
XP_007406983   91 -Ttrpesppinppgrpnlyttgqgwykrkrvqipinqihqskskleesdpkkrklketilsigq---------------- 153  Melampsora la...
XP_003331164   88 -Ttrpdpaisnplkepgpsttgegwhkrkrvpvppvppkvktkneekdpkkrklkeavmalgqre--------------- 151  Puccinia gram...
OAV96244       88 -Ttrpdpattnplkdpetppttgegwhkrkrppappvappkiktksvekdpkkrklkeavmalg---------------- 150  Puccinia trit...
Q54DW3         98 -Afysktsptiieqtkvsipsttqissstnqslpakrklssstnsitst------------------------------- 145  Dictyostelium...
EFA77170      332 -Sfyaktsppvlepprpvpkkkllsfstavsnvpinsdvgspisvigesgsqgaaaaaaslgngasakekdsksq----- 405  Heterostelium...
EGG14439       95 -Slyantpptqtldppkpipkkkiltyqqpvqpaqskdkepsgkghrskdkkgrss------------------------ 149  Cavenderia fa...
6TB4_A        176 -------------------------------rikaitresgkkgmvnsvitqtrqalipkvpvvtrptnvpgnsvqwaQD 224 
KDE02672      218 aallqqqdqaqlqaikeaggvvpsalakrelerererkrdkelvrlstlaaalesgkgrgevdaigggtggktdpaltQE 297  Microbotryum ...
XP_001729242  162 -----assthtsasvwagagaellekkrkederrraveerrrareiklaigashwrlsamqtaaqtesirsrlsttmqEA 236  Malassezia gl...
KIS68213      158 ----------aaslgwagsaadmlekkrkdeekrkvaedrkkvrqyksaigakdwkgqaihgnqqiaavrsklslsaqQA 227  Ustilago mayd...
XP_007406983  154 ----------------rernrikqipkekekekelyqklgnpyhsknpqfdylsreklekvtntllaskmkissstlyQD 217  Melampsora la...
XP_003331164  152 ---------------rnrlkqiallkenelelnsnkfnpqqlaprqlsachylypertenvmntplaskmkissstlyQD 216  Puccinia gram...
OAV96244      151 ----------------hrernrlkqiaslkeeelvklnaqqplprplsacqylypertenvmstplaskmkissstlyQD 214  Puccinia trit...
Q54DW3        146 --------------------------------kekkdkkdasstsstssissssssssssssssskrkkeknptkrprRE 193  Dictyostelium...
EFA77170      406 -----lvsssskskdrdkersdkkkdkthsekskkdklssssssttntpkkkstssssssssssnskrlrsstssttqLQ 480  Heterostelium...
EGG14439      150 ------------------------sslssadtaatttttskskkpkapsssssslssstssrrvskagnnnttttetsLQ 205  Cavenderia fa...
6TB4_A        225 VIHG------FQALL---------ASEIYEL--------------PEMDNLRTRMTGISREHGLiGP--VDDSVIEIMLI 273 
KDE02672      298 YQRiiasssakDSLL---------CSTSKLL--------------PDVDGLRDRMTLIVFESGLvGGgvVDERVGLLGVQ 354  Microbotryum ...
XP_001729242  237 LKRS------VATPN---------CIESQVL--------------PDVHSLQDRMSLSAIEAGLsGG--VHAHAAAVALS 285  Malassezia gl...
KIS68213      228 VMRA------MQAPL---------CVESKHL--------------PDLDGLKDRMTLLAVENGLpGG--VQPQAAAMVLS 276  Ustilago mayd...
XP_007406983  218 YMRC------QQAPL---------CSESKQL--------------PDSDTLKDRMSLIAYDSGLvNG--VDQSAASLALI 266  Melampsora la...
XP_003331164  217 YMRC------QQAPI---------CSESKQL--------------PDFDTLKDRMSLIAYDSGLmNG--VDKAASSLALI 265  Puccinia gram...
OAV96244      215 YMRC------QQAPV---------CSESKQL--------------PDFDTLKDRMSLIAYDSGLmNG--VDKAASSLALI 263  Puccinia trit...
Q54DW3        194 KKD--------STPsisgssssvtiSSSLKLkqkkklfpkyslfsSQLQPLKNKMEEIASENGL-QG--ISKQSIIFMKL 262  Dictyostelium...
EFA77170      481 KREK------RIHPk----------YSLLYC--------------PEIQALKDRMETIACESGL-NG--VSRQSVIYMMM 527  Heterostelium...
EGG14439      206 TKEK------RTHPk----------YSLLYS--------------PEVQSLKDRMETIACESGL-NG--VSRQSVIYMML 252  Cavenderia fa...
6TB4_A        274 GLEQHLKGIVEAAIDIV 290 
KDE02672      355 AVETHLKNIIAHVVGLV 371  Microbotryum lychnidis-dioicae p1A1 Lamole
XP_001729242  286 ALHDYLQNILRRTF--L 300  Malassezia globosa CBS 7966
KIS68213      277 ALQSHLQNVASSIITKI 293  Ustilago maydis 521
XP_007406983  267 ALEVHLKTILGDLLSLI 283  Melampsora larici-populina 98AG31
XP_003331164  266 ALEVHLKTLLGDLLSLI 282  Puccinia graminis f. sp. tritici CRL 75-36-700-3
OAV96244      264 ALEVHLKTLLGDLLSLI 280  Puccinia triticina 1-1 BBBD Race 1
Q54DW3        263 ALEQHILNFLRktkphi 279  Dictyostelium discoideum AX4
EFA77170      528 ALEQHIREILHNTMpvf 544  Heterostelium album PN500
EGG14439      253 ALERHIKDILynsnpql 269  Cavenderia fasciculata
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