Conserved Protein Domain Family
CABIT

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pfam12736: CABIT 
Cell-cycle sustaining, positive selection,
The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologs (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.
Statistics
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PSSM-Id: 403824
View PSSM: pfam12736
Aligned: 42 rows
Threshold Bit Score: 113.703
Threshold Setting Gi: 73920022
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002593555  42 LPQLVKVTYAECEAPg---LSKNEILLLHFTYTSK-K-VMAQSLSKEGGIv-VGPELNIPLAYPGRFELLQNQSNvk--- 112  Florida lancelet
Q3UFT3        32 LPQIARLDSGECVEG----LRENDFLLIHSCRQWT-T-ITAHSLEEGHYV--IGPKIEIPVHYAGQFKLLEQDRDikepv 103  house mouse
XP_012659161  29 LPTLACLGPGEYAEG----VSERDILLIHSCRQWT-T-VTAHTLEEGHYV--IGPKIDIPLQYPGKFKLLEQARDvrepv 100  small-eared ga...
XP_002665828  29 LPTLVRLSNGENVEG----LSEEDVILLHSCRQWT-T-VTAHSLEEGHYV--IGPKIDIPLQYQGKFKLLDQDRDvrepv 100  zebrafish
XP_006625971  29 LPTLVRLGQGDHVEG----LTEQDVILIHSCRQWT-T-VTAHSLEEGHYV--IGPKIDIPLQYPGKFKLLDQDRDvrepi 100  spotted gar
EEN49561      34 LPVFVTVAREDPQAD----LAKDDIYLLRSSYSER-D-VFARKVHRTSGRl-YGPLLTIPLKHPAKFVIFKKVF------ 100  Florida lancelet
EEN49559      30 LPQIVKLADQSLSE-----VADSTILLVSVTKSSY---AVGRSL-AGNNRtlVGPWLSLPLSYNGKFTYLQDTPLrd--- 97   Florida lancelet
EEN50528      39 LPQIVKLTGENGAD-----FPDGALLLLVGLRKDNsRfVVARCMAGDRDRtmVGPWLSIPLSCKSRFVRMSNKQTtk--- 110  Florida lancelet
EEN49558     365 LPQVVRVPRDHQVRVgavqLAGDQHVLLGEARRVR-R-VVAQAVELRSFLp-VGPKLSIPLDFRGRFLLLPLEGWqag-v 440  Florida lancelet
XP_031584072  29 LPTLVRLAHGECVEG----LSEDDVVLLHSCRQWT-T-VTAHSLEEGHYV--IGPKIDIPLQYQGKFKLLDEDRDvrdpv 100  Oreochromis au...
XP_002593555 113 -vFESLEEVinedlQSKMPVVrLLVEED--------ILDSELPPAGVASPEMGMAtTGPrqpLCKk-------------- 169  Florida lancelet
Q3UFT3       104 qyFNSVEEV-----AKAFPER-VYVMEE--------ITFNVKVASGECNEDTEVY-NIT---LCT--------------- 150  house mouse
XP_012659161 101 ryFSSVEEV-----ASVFPDR-IFVMEA--------ITFSVKVVSGEFSEDSEVY-NFT---LHA--------------- 147  small-eared ga...
XP_002665828 101 qyFGSVEEI-----AGVFPDR-VFVMEP--------ITFSVKVVSGEFTEDSELY-NFS---LQA--------------- 147  zebrafish
XP_006625971 101 qyFSSVEEI-----ASVFPDR-VFVMEA--------ITFSVKVVSGEFSEDSEAY-NFT---LHA--------------- 147  spotted gar
EEN49561     101 --YNGVSEL-----LRANPFPeSFRVEEnvtwresgKSQEAFELLGLLSMKMSQNqSKDgghVYAkdmskmkpkvinmsp 173  Florida lancelet
EEN49559      98 prFDGVPGL-----AKSLPDR-VVAKQA------------VSVPMSLVSSNVTGDsDYNviaVAA--------------- 144  Florida lancelet
EEN50528     111 drFQGVKEL-----AEYLPNK-VIATEA-------------------VSELGSSGnSSSqilVNA--------------- 150  Florida lancelet
EEN49558     441 rhFETVSEL-----TASFPDK-VYAKED--------IHLDVFDGIVKTPDKKKVAkTFKhpiVQR--------------- 491  Florida lancelet
XP_031584072 101 qyFSSVEEV-----AGAFPDR-VFVMET--------ITFSVKVVSGEFSEDSEPY-SFT---LQA--------------- 147  Oreochromis au...
XP_002593555 170 --GDVIMIVSAQPREQPAPVqhvQEIPEVHKkglghklraqfkgkgrr--tshtenkepevqrpkmIFTCS-NQDGDLVT 244  Florida lancelet
Q3UFT3       151 --GDELTLMGQAEILYAKTFkekSRLNTIFKkigklnsis------------------klgkgkmpCLICMnHRTNESIS 210  house mouse
XP_012659161 148 --GDELTLMGQAEILCAKTTkerSRFTTLLRklgragalagvggggpggagaaggggarpvkgkmpCLICMnHRTNESLS 225  small-eared ga...
XP_002665828 148 --GDELTLMGQAELLCVQSTrekSRLTALLRrlgkaggal-----------------grpartkmpCLICMnHRTNESVS 208  zebrafish
XP_006625971 148 --GDELTLMGQAEILCAKTVkekSRFNTILRklgksntls------------------kqvkgkmpCLICMnHRTNESIS 207  spotted gar
EEN49561     174 vvGDCLTVIDKTEPIQDSEEvvlDMSQGGGKkktstlkrikssfkg-----kkesrktktvaqpmgYLVCA-NQTGGLVC 247  Florida lancelet
EEN49559     145 --GDELACLGVQHSSTGTIPvteDEDATPGR-----------------------------------LLACL-NQGNEYVT 186  Florida lancelet
EEN50528     151 --GEEIRCLGIEGVHTKPPSkrqLHSNW--------------------------------------TLACL-NENNDYLT 189  Florida lancelet
EEN49558     492 --GDVLTLLAVKKAYRVSKTtkkPKKGSSKAv---------------------------------dCLICA-NQKNERVA 535  Florida lancelet
XP_031584072 148 --GDELSLMGKAELLCATPSkekTGLSALLRrlgkllnif------------------fvssgktpCLVCMnHRTNQSVS 207  Oreochromis au...
XP_002593555 245 LPGDLKARFTLkp--lEFESGTTYTVENVIDNFKLPQDVKLVHGDcPGDDD-----EFTGYVRLFHTYRDEVIVG----- 312  Florida lancelet
Q3UFT3       211 LPFQCKGRFSTrspleLQMQEGEHTIRNIVEKTRLPVNVTVPSPP-PRNPYdlhfiREGHRYKFVNIQTKTVVVCcvlrn 289  house mouse
XP_012659161 226 LPFQCQGRFSTrspleLQMQEGEHTVRAIIERVRLPVNVLVPSRP-PRNPYdlhpvREGHCYKLVSIISKTVVLGlalrr 304  small-eared ga...
XP_002665828 209 LPFQCRGRFCTrslqeLQMQGGEHTVRSIIERVRLPVNVSVPSRP-PRNPYdlhaiREGHRYKLLSIISKTVVLCcilrk 287  zebrafish
XP_006625971 208 LPFQCKGKFSTrspleIQMQEGEHTIRSIIEKVRLPVNVMVPSRP-PRNLYdlhiiREGHRYKLVSIISKTVVLCcilrk 286  spotted gar
EEN49561     248 LHTDCTGRFSAyl-------pEQYTMEELLENFKLPGDVEVVGGKlPDDHP-----NFGGRLRLLSFCTETFLVV----- 310  Florida lancelet
EEN49559     187 LPFDCRSQFVAiaggvTGKGEEEESLEKIVAENRLPLTVLQTEGDiPKFCGd----TFTGVIRLAHLANKEETIL----- 257  Florida lancelet
EEN50528     190 LSLDCSAKFLAvasvaAEQSPEEETIDKLAS-DTFPITVLQTNGEtPKFCQd----TFTGIFRLVQAREDRMISA----- 259  Florida lancelet
EEN49558     536 LPISFPGKFVT-----------VHNIEEIVKNYRLPVMVQLVQGQaPAVD------NFTGVLTLMETGTDHSVQA----- 593  Florida lancelet
XP_031584072 208 LPFGCRGRFCTrspleQGMLGGEHTVRSIIERVRLPVNVSVPSRP-PRNPYdrhavREGHRYKLLNIVSKTVVLCmvlrh 286  Oreochromis au...
XP_002593555 313 -------TSVQ--------DDGQisqvefsintdiQFSPADLELSENKEILRLF 351  Florida lancelet
Q3UFT3       290 nkilpmhFPLH--------LTVP------------KFSLPEHQVKGDMWPETLV 323  house mouse
XP_012659161 305 egpaplhFLLL--------TDTP------------RFALPQGLLAGDPRVERLV 338  small-eared galago
XP_002665828 288 eevmpshFLLL--------TDMP------------RFTLPEGLLRADAPYQQVV 321  zebrafish
XP_006625971 287 eevtpfhFLLL--------TDMP------------RFLLPEGLLRGDPLFEKAA 320  spotted gar
EEN49561     311 -------NGLPkqgevtgaGVQAavvtelsidsdvRFTPARKSSPQNVELLKLL 357  Florida lancelet
EEN49559     258 -------SCLLrk----enGKLKyeflelplrskvGVLAAHGMLGDQTDYNIAV 300  Florida lancelet
EEN50528     260 -------CLLRtg----anGAVLyqflelpaattsAVLLPEGMVKDEVSYNLLL 302  Florida lancelet
EEN49558     594 -------RLVSpeg---eiDTEPfripvigkkiqlKILTGETKTEDTEDgqede 637  Florida lancelet
XP_031584072 287 qevspshFLLL--------RCMP------------RFNVAEASVHKAALeslll 320  Oreochromis aureus
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