Conserved Protein Domain Family

pfam12734: CYSTM 
Cysteine-rich TM module stress tolerance
The members of this family are short cysteine-rich membrane proteins that most probably dimerize together to form a transmembrane sulfhydryl-lined pore. The CYSTM module is always present at the extreme C-terminus of the protein in which it is present. Furthermore, like the yeast prototypes, the majority of the proteins also possess a proline/glutamine-rich segment upstream of the CYSTM module that is likely to form a polar, disordered head in the cytoplasm. The presence of an atypical well-conserved acidic residue at the C-terminal end of the TM helix suggests that this might interact with a positively charged moiety in the lipid head group. Consistently across the eukaryotes, the different versions of the CYSTM module appear to have roles in stress-response or stress-tolerance, and, more specifically, in resistance to deleterious substances, implying that these might be general functions of the whole family.
PSSM-Id: 403822
View PSSM: pfam12734
Aligned: 42 rows
Threshold Bit Score: 26.8485
Threshold Setting Gi: 189197197
Created: 21-May-2020
Updated: 7-Aug-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
XP_015570444         36 PPPpppPPYYQDyfyppppppppQDN----RQ---DDsGcssFLKGCLAALCCCCLMEECF 89  castor bean
P40388               51 AQQ---PMYVQ------------QPQ----ASd-pGG-D---LCCGLLTGLACCCCLDAMF 87  Schizosaccharomyces pombe 9...
XP_002850283         51 PQQ---PMYYQQqpp-----vddRGK----SSs--SG-G---LCAGLMAGMACCCCLDILC 93  Microsporum canis CBS 113480
XP_001389607         76 QQQ---QGYYAG-----------QDR----GGs-sGG-G---ICAGIMAALACCCCLDILF 113 Aspergillus niger CBS 513.88
CAP71316             68 PPQ---GQYYPPq----------QQE----KK---GP-G---FFEACLAGMACCCCLDILF 104 Podospora anserina S mat+
XP_001742985        240 HNG---QYYYAQpqqqpgqpqhaQHHhgdaTKg--SG-G---FCAGLFTALAVCCCCDIIF 291 Monosiga brevicollis MX1
Q5BFC6               77 PPQ---QGYYA------------EEQ----RGgggGS-G---ICAGLLAGLACCCCLDILF 114 Aspergillus nidulans
EEH08566             64 PQQ---PMYYAPqpqgh-yvdnrDSS----RGt--GG-G---ICAGILAGLACCCCLDILF 110 Histoplasma capsulatum G186AR
WGS:AATM:SJAG_02333  47 PQQ---PMYVQ------------QPP----PQ---ND-Gs-dMCCGLMTGLACCCCLDACL 83  Schizosaccharomyces japonic...
Q6C8L3               34 PPQ---PVYVQQ-----------QQP----QGg--NN-D---CCCGLCAGLACCLCLDCLF 70  Yarrowia lipolytica
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