Conserved Protein Domain Family
RHIM

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pfam12721: RHIM 
RIP homotypic interaction motif
RIP proteins are receptor-interacting serine/threonine-protein kinases or cell death proteins. This interacting domain is involved in virus recognition. The RHIM domain is necessary for the recruitment of RIP and RIP3 by the IFN-inducible protein DNA-dependent activator of IRFs (DAI), also known as DLM-1 or Z-DNA binding protein (ZBP1). Both the RIP kinases contribute to DAI-induced NF-kappaB activation. RIP3 undergoes auto phosphorylation on binding to DAI.
Statistics
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PSSM-Id: 403811
View PSSM: pfam12721
Aligned: 29 rows
Threshold Bit Score: 39.7501
Threshold Setting Gi: 47209451
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002589403  145 EEPLT--TKS-------SLTSETdatddiEGACGSTSLPPRACPGngptPVTVQVENAFAVQVGNGNVLIS 206  Florida lancelet
EDL85116      165 PAVIY--QQNpinmicqQGPNSL-----------------------------ISISNSKAIQIGHGNVMSR 204  Norway rat
XP_015155511  674 PSPSQ------------------------PLNLPSGQHYTTTDPGg---ARSIIIQHARMVQIGNHNTMHV 717  chicken
Q80UF7        655 PVSSP--Q---------------------SQSFPSASSPAPQTPG----PQPLIIHHAQMVQLGVNNHMWG 698  house mouse
EGV93716      618 PVSSP--Q---------------------SPPFPSASPAATQTPG------PLIIHHAQMVQLGVNNHMWG 659  Chinese hamster
XP_014978020  653 SLPFS--Q---------------------PPAFPTASPAPPQSPG----LQPLIIHHAQMVQLGLNNHMWN 696  Rhesus monkey
AGT36583      655 PPAFP--Q---------------------PPAASQSSPVNPQSSG----VQPLIIHHAQMVQLGLNNHMWN 698  pig
XP_023500240  353 PSFPP------------------------PSTPPSARPAPS-NPG----PASPEAQPSEQK---FYNFVVL 391  horse
Q06A28         19 dvPMP--DDG-------QGGQQT------ATTAAGGAFGVGGGHSv---PYVRIMNGVSGIQIGNHNAMSI 71   Murine cytomegalovirus...
KAE8597761    493 PTPETgaQ---------------------SSHPRSQLFARDDRTGvvdnGLNVSISNSNSIQIGNHNTLSV 542  tropical clawed frog
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