Conserved Protein Domain Family
Apq12

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pfam12716: Apq12 
Nuclear pore assembly and biogenesis
This is a family of conserved fungal proteins involved in nuclear pore assembly. Apq12 is an integral membrane protein of the nuclear envelope (NE) and endoplasmic reticulum. Its absence leads to a partial block in mRNA export and cold-sensitive defects in the growth and localization of a subset of nucleoporins, particularly those asymmetrically localized to the cytoplasmic fibrils. The defects in nuclear pore assembly appear to be due to defects in regulating membrane fluidity.
Statistics
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PSSM-Id: 403806
View PSSM: pfam12716
Aligned: 64 rows
Threshold Bit Score: 27.9292
Threshold Setting Gi: 156839109
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPS32268      61 MPDLMTSLMLAGLLVVSLVILDYIRRLviwwVMWWVRFLVRLVFWGSVVFVGFYVYN 117 Penicillium oxalicum 114-2
EEQ38389      47 FPRASDLATTGLLIYLFYKISRRLFTM----WIKLLTSIVKFTFFLVLFFVVSTIYI 99  Clavispora lusitaniae ATCC 42720
EGW33773      36 YPDLTAITVVLLGSYATYRILKKSAKM----WINFIFTLIKLVVVLTIVLSGVMIYF 88  Spathaspora passalidarum NRRL Y-27907
EDK47142      35 YPDATSTVVIIVGSYISYRVAKRAIRS----YISFIYLLVKITCVVGFVAVVMALYG 87  Lodderomyces elongisporus NRRL YB-4239
XP_719318     36 YPDITNVIFFILGVYIIYKILVRTLRS----WFNFMIFTIKLIFVLFFVFLVFVIYL 88  Candida albicans SC5314
EER30476      37 YPELTNILFLLIGVYIFYRVLIRAFKT----WFNFLIMTIKTLLVLFFIFLVFIIYI 89  Candida tropicalis MYA-3404
CCE42471      32 YPEYTNIVFTIIAGYIVYSLLVKSAKA----WIRFTISLMKSVLVVAFIVLAYAISV 84  Candida parapsilosis
P40532        38 HPLVFQLLFIFFTFYVFYKLLMN------------FITLVKRFLYLTLVVTCIGIYM 82  Saccharomyces cerevisiae S288C
XP_001643249  38 HPTLFLSLFSLFALYVIYRIFSN------------IISIIRRLFYILIILFGVFCYL 82  Vanderwaltozyma polyspora DSM 70294
Q6FLT0        42 YPTAFIVISLIIGLYVVWRCIMS------------LYAMVRRLFYLSLVLLVVCAYM 86  [Candida] glabrata
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