Conserved Protein Domain Family
G-patch_2

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pfam12656: G-patch_2 
G-patch domain
Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ATP-dependent DExH-box splicing factor Prp2. As this interaction involves the G-patch sequence in Spp2 and is required for the recruitment of Prp2 to the spliceosome before the first catalytic step of splicing, it is proposed that Spp2 might be an accessory factor that confers spliceosome specificity on Prp2.
Statistics
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PSSM-Id: 372242
View PSSM: pfam12656
Aligned: 56 rows
Threshold Bit Score: 50.7378
Threshold Setting Gi: 146452806
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002293329 260 AADVDPTsnVYANVSIGDFGSA--LLRGMGWNgsASGNINNNGNSRlgggakrlggskptdEEVIKPRPH-RLGLGATPL 336 Thalassiosira p...
EEC04522     737 PMPAQQNyeEPTKAGIGEDNIGnkMLKAMGWS--EGQGLGKSNTGTt-------------nIVEVQRRVT-SAGLGVRGA 800 black-legged tick
A0EB76        19 PDNTEDT---YSKAPVSQFAQN--LLSKMGFQ--EGQPIGKNSQKSsal----------lkPIEFLSRGD-REGLGVNPM 80  Paramecium tetr...
Q21924       139 DGRGDTEdaDYSAIPIESFGLA--ILRGCNWK--DGDGIGKNPQKVa--------------LKLPNRRPP-GLGLGATPK 199 Caenorhabditis ...
EDO05339     210 DHEDTDVepSYENVAVEEFGLA--MLLGMGFN--PATNTNKPK--------------------EYKRRAYdRAGLGADAH 265 Babesia bovis
EEA05789     126 KTSSELVylKESKIPIDSFGMA--MLKGMGYD--PSIHKTRPK--------------------LYKKRTYdQGGLGSDLI 181 Cryptosporidium...
Q4N0N3       180 GKMLRVDksQYDKVPVENFGMA--MLMGMGYN--PNNTQENDNTMK-----------------KYTKRIYeRGGLGTDTI 238 Theileria parva
Q4UCY1       214 KKILKLDkrQYEKVPVENFGIQ--MLMGMGYN--PKINKENNK--------------------KYIKRIYeKGGLGTDII 269 Theileria annulata
ESS29474     334 PDALSATsaEYSRIPVSEFGLA--MLRGMGYD--AEKKEETTKGA-----------------APKRKRTYnRAGLGSEEE 392 Toxoplasma gond...
Q5CPI8       115 DDLDSSTnkDNFRIPVDKFGIA--MLRGMGYN--PEIHNTKPK--------------------IFKKRNYnQSGLGADKE 170 Cryptosporidium...
XP_002293329 337 P 337 Thalassiosira pseudonana CCMP1335
EEC04522     801 T 801 black-legged tick
A0EB76        81 K 81  Paramecium tetraurelia
Q21924       200 N 200 Caenorhabditis elegans
EDO05339     266 M 266 Babesia bovis
EEA05789     182 I 182 Cryptosporidium muris RN66
Q4N0N3       239 M 239 Theileria parva
Q4UCY1       270 M 270 Theileria annulata
ESS29474     393 V 393 Toxoplasma gondii VEG
Q5CPI8       171 I 171 Cryptosporidium parvum
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