Conserved Protein Domain Family
Colicin-DNase

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pfam12639: Colicin-DNase 
DNase/tRNase domain of colicin-like bacteriocin
Colicin-like bacteriocins are complex structures with an N-terminal beta-barrel translocation domain (pfam09000), a long double-alpha-helical receptor-binding domain (pfam11570) and this C-terminal RNAse/DNase domain with endonuclease activity. Their competitor bacteriocidal action is by a process that involves binding to a surface receptor, entering the cell, and, finally, killing it. The lethal action of colicin E3 is a specific cleavage in the ribosomal decoding A site. The crystal structure of colicin E3 reveals a Y-shaped molecule with the receptor binding domain forming a 100 Angstrom long stalk and the two globular heads of the translocation domain and this catalytic domain comprising the two arms.
Statistics
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PSSM-Id: 403742
View PSSM: pfam12639
Aligned: 19 rows
Threshold Bit Score: 83.2632
Threshold Setting Gi: 81432708
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q813C4                   110 GIEYKNGVPDFSPVAKAQLEIDYMLGgkgakgntARDYNFKQANERLADQLNNSPELANQfgMEAGGITAKdiEKYRVKN 189  Ba...
CCY99071                 142 IKFDKKGFPVFKSICTITLPRKYRYQ--------TRDVHFRCASKLLYKRAVSNRYVRCK--FTKSELATF--KCGDVPS 209  Cl...
WP_015433209             360 VPFDSKGYPIFDDIAKYDTRLDIKSFrs-----aTYPEQMEMATKQLYKDLGED---GLKklFNQKQINAIk-NGDKKIP 430  Bi...
USMARC:WQG_17940          94 IPYDSRGLPIFDDVAKFTTKIEKPKNyqnmsnkvRREAEMRNATLALKREIESGRVNKNI--FTKEQLEQIn-NGTYKIV 170  Bi...
Q97IJ5                   194 GIEYRNGVPDFTPVSKANIEIEHMVGgklkmgtkAREINFVQADKKLAEQLNNSPELARKfgMESGEISVKdiRNFRKKN 273  Cl...
zhongguo:DGo_PD0001      244 IYISKQGFPQFGPYA-------------------THTVKIDMKGNREYTLPDGDFANANI-------KAGF--AKSKKHK 295  De...
jgi:Haur_2036           2989 VPFDAQGYPDFSAYS-------------------IKDVQIDMRGNR-----GSDFAKADQ-------AAGY----TVRPS 3033 He...
Q21ED9                   494 VTYDAEGFPDFSPYLYDKG---------------VNTVNIKLTGNR-----NQDFALANQ-------LAGFgnSAKSTPK 546  Sa...
PRJNA329150:BB341_29800 2233 VPFDAQGFPDFSAWRHPQ----------------VPDVRIQLTGSR-----SRDFRLANQ-------AAGL----PSTPT 2280 St...
Q6NG78                  1149 IYFTDEGFPIFDRFVAQFDANAMTFNpeamphgkVPDVTITPTGRSYKDIRAADAVLGID-------------RRYRKEH 1215 Co...
Q813C4                   190 KLTWHELN--DGVTIQLVPTEINAKFGHLG 217  Bacillus cereus ATCC 14579
CCY99071                 210 KYTWHHHQ--SAGVLQLVDRKVHANTPHIG 237  Clostridium sp. CAG:793
WP_015433209             431 GFTWHHHQ--DTGRMQLVPEWQHSKTGHIG 458  Bibersteinia trehalosi
USMARC:WQG_17940         171 GFTWHHNAqsSPNNMQLVPEKIHNSIKHIG 200  Bibersteinia trehalosi USDA-ARS-USMARC-192
Q97IJ5                   274 KYTWHELN--DCKTIQLVPSKINNAFGHVG 301  Clostridium acetobutylicum
zhongguo:DGo_PD0001      296 GYTWHHHE--DRTTMQLVPYKLHDKFRHSG 323  Deinococcus gobiensis I-0
jgi:Haur_2036           3034 GYTWHHHQ--DRTTMQLVPTDLHGDVAHTG 3061 Herpetosiphon aurantiacus DSM 785
Q21ED9                   547 HFTWHHHQ--DLGVMQLVRTDVHKLSPHTG 574  Saccharophagus degradans 2-40
PRJNA329150:BB341_29800 2281 GYTWHHHQ--DRGLMQLIDRQVHADTGHTG 2308 Streptomyces clavuligerus
Q6NG78                  1216 GLVWHHHQ--DTGRMQLINKDVHDAVKHTG 1243 Corynebacterium diphtheriae
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