Conserved Protein Domain Family
Vezatin

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pfam12632: Vezatin 
Mysoin-binding motif of peroxisomes
Vezatin is a peroxisome transmembrane receptor that is involved in membrane-membrane and cell-cell adhesions. In the movement of peroxisomes it binds to class V and class VIIa myosins to guide the organelle through the microtubules and allow pathogens to internalize themselves into host cells. Vezatin is crucial for spermatozoan production. In mouse cells it interacts with the cadherin-catenin complex bridging it to the C-terminal FERM domain of myosin VIIA.
Statistics
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PSSM-Id: 403736
View PSSM: pfam12632
Aligned: 30 rows
Threshold Bit Score: 133.6
Threshold Setting Gi: 74584318
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011489592  150 LLGLAAVLLGLCSssssse---gpwllALAPWGLTLLGWV---GLRG--AALWRRGRMQRAVHSRATQLQALLHDSKTLT 221  Japanese medaka
XP_011275534  231 ILGVLSHLQKHKG--------------NYQNSQIRLVIIIsliILNA--HTISHTQSLDLIQHKTLNQLKRFIKIQQKFD 294  Wickerhamomyc...
EEQ39047      183 TVLLIVYLLKQRLlprq------tldsSQHYQLFKLLLIMatkIVKF------QRAAILIYSSKTLRSLDDFMLSNCQIN 250  Clavispora lu...
Q59N02        327 VILMIIYLLKQQQlmsyqhhhnyglsiKIQFKLFKIIIYIsmkLIKV------KKFKLIIESNQILLNLQKFLILNYKIN 400  Candida albicans
ABN64437      296 IINLIIFLMKQEQrrhlny--satmsySNRMKMFKILLIIstkLIKF------NRFKLLVMSQSNLSYLNSFLLSNYSIN 367  Scheffersomyc...
EGW34170      183 IINLIIYLLKQRKtneh-------tnqSNQLKFFKIILIIstkLIKV------KKFRTLVQTSQILNLLNEFLMSNYIVN 249  Spathaspora p...
XP_001486211  164 VIHLIIFLIKQSLkeds------hllsHSKHKLFRILLVVstrMIQF------KRIGLRIKANKILNYTEEFLKLNYKIN 231  Meyerozyma gu...
Q6BGY9        189 TIYMIIFLLKQSLkgvks-----kmstQNKFKMFKILLIIsvkLIQF------KRINLKIQSTKVLNMLNDFLVNNYKVN 257  Debaryomyces ...
CCU76264      143 sAFSLAWLIHWARts----------arSAAGRGRLAVMLTvlgIAGMisYAYFRRQWLQNLRQETVTELSNLIVSAYELD 212  Blumeria gram...
CCX30800      156 vAGVAGVVLSWVFr------------gSIFSKGRALFAAAftiGMGVflFTRARRKWLRSLRSKAVEFAAVFVENSQTFD 223  Pyronema omph...
XP_011489592  222 GLSRKALRLVQE--TEVISRGFTLlldrvsaassfsragpGAMPRGQQLIGLRKALYRALRSAFRASRRATCHMLKafpl 299  Japanese medaka
XP_011275534  295 LQEQKLITKYKE--LKLYNNILPI----------------QQQHSSEDPSQLFDLVSSTIIVASTSVINSIHKILP---- 352  Wickerhamomyc...
EEQ39047      251 KDIITSIITLKE--FQMFSFLDRPk---------------QEQISSGYPKDLAKHLNTTLRLLSLNMKHSISALLP---- 309  Clavispora lu...
Q59N02        401 KKLIIQLINLKGdqLNLISNS-------------------SGGGGDGFEQQLKQYLFNILSLLNLNLQNSIIKLLP---- 457  Candida albicans
ABN64437      368 KKLIQKLIILKE--LDVYYYVNRNkde----------anhDSKSREVYKSSLREHLANTLHFLNLNLRTSIARLLP---- 431  Scheffersomyc...
EGW34170      250 KKIILQMIRLKE--LHTYNFLP------------------GQGDNVSYKSHLHSHLLSSLSFLNLNLKSSIMDLLP---- 305  Spathaspora p...
XP_001486211  232 KKLISHMIRAKE--MAIFTGTS------------------LSSSGSNDPTSLMKTLDETLSFLIFNLKSSIVRLLP---- 287  Meyerozyma gu...
Q6BGY9        258 KKLIMNLINLKE--MEIFGFMK------------------NSAISKNKVHDLKENLDNTLNFLNFNLKSSIIKLLP---- 313  Debaryomyces ...
CCU76264      213 RAAANAISLVQE--VELVSRGYRIssplp------pisriEDRSQSRRCIRLRKQIRKSFVDVTTKYVEAVSQLQP---- 280  Blumeria gram...
CCX30800      224 ILASNAVTLIQE--VELVSRGYRLslplp------pitrlERDNKTRRCARLRKSVLSALSMVIPPHNRACMSLRQ---- 291  Pyronema omph...
XP_011489592  300 SSEIDNVTNYVCAVPLKELglGLGIEHl---------gDEQAQELTDDYSLPALKMLFQLWVGQSSECFRRLALLLSPYR 370  Japanese medaka
XP_011275534  353 YVNGYELENYCELYNIELTqlGFETEN-----------LKPFNISESESSIDQLVNKFRRFQYLRRFLIVLFLAMNHQFS 421  Wickerhamomyc...
EEQ39047      310 FSNGEILEKYCQINNVQMS--WIFEEH--------------DESIEEVSSLEILTSKLGHFNNLRRFFICQLLTIHDPPS 373  Clavispora lu...
Q59N02        458 FMNGELLEQYCLMNNIKID--ILNQDNeiist-vgrgyTLGSNSNSNSSCLDNVKFHFKKFDNLRKLFICQLLIINQ-PS 533  Candida albicans
ABN64437      432 NLNGDLFEQYCNLNNIDIL--LLQEDYrdgdeeelngmDSPVSSSKEKNSLDEIVFNMNKFNQLRKLFICQLLTINESSV 509  Scheffersomyc...
EGW34170      306 VLNGDLLQQYCNINSIDLE--ILTQEY--------------TPDDNQDEYINEIIFNITKFNQLRRLFICQLLAINQTPV 369  Spathaspora p...
XP_001486211  288 FLNGPTFEQYCHINNINID--ILGKSL-----------------DETELTIDTLRSKLDKFHKLRKMFLCQLLTISERQS 348  Meyerozyma gu...
Q6BGY9        314 FLNGPMFEKYCNINNINVC--TLNSKYda-------dgTIEINRSSEKITIDELTFKLNKFNQLRKFLVCQLLTVNESPI 384  Debaryomyces ...
CCU76264      281 LAEELDLEKYYDIYDITEN--DLTEASl---------gYSEIEAE-DQESVRTLKLLAARYNTLRRIFLCSLMALNADGN 348  Blumeria gram...
CCX30800      292 LAQEQDLEKYYDIYDIQMA--DIAEAEl---------gFDPNEDLGDLQSLRALKTLLHRLHTIRRVFLCSLLAIDAEGS 360  Pyronema omph...
XP_011489592  371 TDEPEEGKSKAvgs-------pplPMHRSIAAmteplhhaltsclaevqrsydfh-----rhfetqprtassdrtgrare 438  Japanese medaka
XP_011275534  422 THSPFLMKVFGifqiksrltcsilKSSVLVSQ------------------------------------------------ 453  Wickerhamomyc...
EEQ39047      374 H-NFFISKIRD-------------YLptpikts-------------------------------------------tyts 396  Clavispora lu...
Q59N02        534 KPNFFLFKLMDqf---------niDDSNSSSSfsenffnn-----------------------------------svpif 569  Candida albicans
ABN64437      510 KKNFFIYKLMD-------------QFppiktedwerd------------------------------------dditafn 540  Scheffersomyc...
EGW34170      370 RYNFFIYKLMD-------------QFnldsrev--------------------------------------------qis 392  Spathaspora p...
XP_001486211  349 Y-NFFLSKAWDlf---------nlPQAETRELcstpi------------------------------------------s 376  Meyerozyma gu...
Q6BGY9        385 R-SFFLFQVWDqf---------niTEYEVDEVlqndf------------------------------------------l 412  Debaryomyces ...
CCU76264      349 KNDFHVWKIA--------------------LErirdtrvatasagarlatllntee---sfpvpptpklpltpgrerwra 405  Blumeria gram...
CCX30800      361 FSDYTRWGLA--------------------VEqlrslgnltaelavelrkilveeeqfslpltpstsphtlspttenhrt 420  Pyronema omph...
XP_011489592  439 kcrELNTLHTSIRSLQLHLK 458  Japanese medaka
XP_011275534  454 ---SLESLQELISGLVESLS 470  Wickerhamomyces ciferrii
EEQ39047      397 tidKLKSLQLVFQEHTAALE 416  Clavispora lusitaniae ATCC 42720
Q59N02        570 dslRLKIIHDLLIDHNLTLS 589  Candida albicans
ABN64437      541 niaKLGFIRQVLHDHNKITN 560  Scheffersomyces stipitis CBS 6054
EGW34170      393 dynRLNLIKRVMTNHNQTSS 412  Spathaspora passalidarum NRRL Y-27907
XP_001486211  377 vleKFIILEDIFHEHNQTVS 396  Meyerozyma guilliermondii ATCC 6260
Q6BGY9        413 ffeKLLVVEELFEEHTNIVK 432  Debaryomyces hansenii
CCU76264      406 qsrQLNSLSTGIRGLQAKLQ 425  Blumeria graminis f. sp. hordei DH14
CCX30800      421 qlrKLNSLSQALRGLQakmh 440  Pyronema omphalodes CBS 100304
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