6CBC


Conserved Protein Domain Family
Chorein_N

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pfam12624: Chorein_N 
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N-terminal region of Chorein or VPS13
Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.
Statistics
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PSSM-Id: 403729
View PSSM: pfam12624
Aligned: 185 rows
Threshold Bit Score: 49.8931
Threshold Setting Gi: 74855181
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6CBC_A                      6 VAGLLNRFLGXYVKNFDPKQL-KWEV-WNGKVRLDNLELQREALDQL--KLPINVIKGHLG--HLVLHIPWKTLASEQ-V 78   C...
EGG20936                  783 IAEVIDRFLGSFLQEVTKKQL-KIGL-FGGNVVLKNIEVKPEAFRAF--DLPIQVNRGVVG--RLIVKVPWTSLKSES-V 855  C...
XP_001314165                5 VANVISYFLGEYIEDIDKSKI-SVSL-WNKNAVLQDTLIKKNAL--MrhQVPFEITSGVIG--MLDLQIE-KLVKSLP-M 76   T...
WGS:AAFB:cds.EHI_065700A    6 IADFLTKTIGKYIEDLDVNSV-SVSL-WNGNVQLKNLQVKKDACSAF--NLPVIISKGILK--TLEVEVPWKSIKTDP-F 78   E...
A0E9A9                      9 FIKRLQSYLLEYLQDFSQNNMaKFSLgLSSNIVLKNLCIKKQALLNF--KFPLYIKDGKIN--QITLNMPLNYKKQQPeM 84   P...
A0CQA1                      9 FVKRLQSYLLEYLQDFSQNNMaKFSLgISSNIILKNLQIKKQALLNF--SFPMYIIDGKIN--SITINMPLNYKSQQPeM 84   P...
A0CWT7                      9 FVKRLQTYLLEYLQDFSQNNMaKFSLgISSNIVLKNLQIKKQALLNF--SFPMYIIDGKIS--QITINMPLNYKAQQPeM 84   P...
XP_001609010                7 IISLLHRLLKPFIEGIDENTL-HLRNlLSGNVVLTGLRLKPSIVHSL--GLPYHLTFGLIDevKLTVRLPLLSLSKSK-L 82   B...
Q4N8I7                      6 IIQLLNNVFDSYIEGIDQSKLaQINL-WGGKIVLNALHLRPDIFDIL--ELPFHLTFGFLGsvVIKIQIPIISLSRKN-L 81   T...
ESS28716                    6 LLSQLNAVLCQVFETISRQQV-EASL-LGGKLVLKKLRLKERILASY--SLPICVTYGVLK--ELRVQVNWFRLLSHP-V 78   T...
6CBC_A                     79 KINIEDVFLLA-SPKEe-aEYDEDeEARRRHRLKXEK 113  Chaetomium thermophilum var. thermophilum DS...
EGG20936                  856 VIQLEDIYIFA-SAAQqssAFSSSsSSSFSTTSNISk 891  Cavenderia fasciculata
XP_001314165               77 NMNLTDIYILGkVRSDisiA-----KEALEANTEKSE 108  Trichomonas vaginalis G3
WGS:AAFB:cds.EHI_065700A   79 KIKIKGLHIIS-QPQTv-fVFDAEqYDLKKKEHRKEI 113  Entamoeba histolytica HM-1:IMSS
A0E9A9                     85 IIEGIDLHVCTiQEANqsaQNKDS-QTQGIDNLKKHK 120  Paramecium tetraurelia
A0CQA1                     85 IIEGIDLQVCTiQEANqfvSNKEQqSQQGVENLKKHK 121  Paramecium tetraurelia
A0CWT7                     85 IVEGIDLQVCTiQEANlfvSNKDQqSQQGVENLKQHK 121  Paramecium tetraurelia
XP_001609010               83 VLEINNVVLLL--TSLpetQWDSAsFREEHMAHKVTT 117  Babesia bovis T2Bo
Q4N8I7                     82 SLDISDLLLLM--TTKpesQWDPElYRDEYLSTKIAV 116  Theileria parva
ESS28716                   79 VVEADGLLVVA--TTIptnEWDVAvERDNLSEQKKLR 113  Toxoplasma gondii VEG
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