Conserved Protein Domain Family
MCM2_N

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pfam12619: MCM2_N 
Mini-chromosome maintenance protein 2
This domain family is found in eukaryotes, and is typically between 138 and 153 amino acids in length. The family is found in association with pfam00493. Mini-chromosome maintenance (MCM) proteins are essential for DNA replication. These proteins use ATPase activity to perform this function.
Statistics
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PSSM-Id: 403724
View PSSM: pfam12619
Aligned: 21 rows
Threshold Bit Score: 88.2363
Threshold Setting Gi: 299751403
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001525450         92 NDLEDEIQN-DVADLN---PS----DEEEGDDLM-DN-FERDYRENAEQDHYD-LgdHNIDDTgDFDEMDMATRRRIDEQ 160  Loddero...
XP_009158281         52 LGPEDDLIG-DIDDAD---ELa---EEEDGIDLFgDT-FMDDEREGRDQETYQ-G--RMIDDEgDYDDLDLAERRQLEAR 120  Exophia...
GAD94620             57 RDEEAEMLD-DIDDID---EMa---EDEDGIDLFgDN-FDRDERSGRHDEDYG-G--VGIDDEgDYDELDPAARRQLEAR 125  Byssoch...
WGS:AATM:SJAG_02348  44 EAEEAVVEE-EIGELDdelPDp---NEEDGEDLFgED-MEKDYVQNLELDRYD-I--DDLDDEnEFETMDIGERRALEQK 115  Schizos...
P40377               43 EAAEALVEE-DIEDLDgeaLDv---EDEEGEDLFgEG-MERDYQQNLELDRYD-I--EELDDDnDLEELDIGARRAVDAR 114  Schizos...
EPY49349             43 EAAEALVED-EIEDVDnenVDv---DDEDGEDLFgED-MERDYQQNLELDRYD-L--DELDDDnELEELDLGDRRIIDEK 114  Schizos...
XP_001732725         65 MDSHSMLDQvDDDPDDlvnGAe---NEDDGEDLFdDT-MMADYRANPELDTYEaV----GLDEaDFEHMDATTRQLAELR 136  Malasse...
XP_001830245         49 pppfsdtdEsGIDDRDgllDAegedEEEDGEDLF-EN-LEADYAPNELLDRYS-D--ADIDDDgDAAELSAAQRRAAEAQ 123  Coprino...
Q5KDY4               64 ADDEAEVRRiGRENGDd-------dEEEEGEDLFnDD-MMADYEENAGLDTYS-Q--ADLDDRsSVAGPTRAERLAAERA 132  Cryptoc...
EKC97426             57 DDEEAEMRArGRRDAG---DEd---TDDEGEDLFnDDnLQRDYEVNPELDRYS-D--AGLDDRsSVQEMSRADRLAAERE 127  Trichos...
XP_001525450        161 LNRRDAILK-------NASRSR-GGVFLDDDE-DDdedaegirgqnEGMDQYGLPIQRRRRRQHfdddNAD----QDDML 227  Loddero...
XP_009158281        121 LNKRDREL---------ARRRRmPAAFMPDDD-DD-------------AGID-LTRQPRRRRHHy---DEDq---EDMDL 170  Exophia...
GAD94620            126 LNKRDREL---------ARRRRmPAAFLQDDD-DD-------------MNVDNLTRQPRRRRHHy---DEDa---EDMDM 176  Byssoch...
WGS:AATM:SJAG_02348 116 LNERDQKSGk------aSGKGK-PAAFLQEDD-E------------DLNSDFGFPF-KHRNRQY------DelepTATVM 168  Schizos...
P40377              115 LRRRDIELDa------aAGRTK-PAAFLQDED-D------------DLDSNLGTGFTRHRHRIY------DeyspNVGAL 168  Schizos...
EPY49349            115 IQRRDMELEa------aAGRTK-PAAFLQDED-D------------DLDSNIGLGIPRHRHRVY------DefapNAGAL 168  Schizos...
XP_001732725        137 MARRDRAEGvgrm-------srrAPVFLQSDDeSEd-----------------DVLRQRRRRRHy-----------DEVQ 181  Malasse...
XP_001830245        124 MARRDRLERagkkgsrAFIRTK-APTFLGSDDmDDd---------gDVDDELGLSQFKARTRRHy-----------DERR 182  Coprino...
Q5KDY4              133 MDLRDRGVSgr----rAGRRDH-MPAFLQSDD-DEa---------eAFGDDPLAGINIRRRRRQy-----------DERM 186  Cryptoc...
EKC97426            128 MARRDRGLTgg----rAARRGR-VPTFLQSDD-DDd---------gAVDGGLLSGINTRRTRRQy-----------DERM 181  Trichos...
XP_001525450        228 DDMeIDPFNEELSLESLTDIKAPSI 252  Lodderomyces elongisporus NRRL YB-4239
XP_009158281        171 DE---NIMEEELSLETLQDVKASNI 192  Exophiala dermatitidis NIH/UT8656
GAD94620            177 GD---DIMEEELSLEELADVKASNI 198  Byssochlamys spectabilis No. 5
WGS:AATM:SJAG_02348 169 DE------DGELQLEAIADVKADSI 187  Schizosaccharomyces japonicus yFS275
P40377              169 DE------SGELPLESIADVKADSI 187  Schizosaccharomyces pombe 972h-
EPY49349            169 DE------AGELPLESIADVKADSI 187  Schizosaccharomyces cryophilus OY26
XP_001732725        182 EED--AAEVDELPIEQLSDIKADSI 204  Malassezia globosa CBS 7966
XP_001830245        183 DQDdMEGIEDELPLEQLGDIKAKSI 207  Coprinopsis cinerea okayama7#130
Q5KDY4              187 DEDdVEEDEEEMSLEHLGDVKAASI 211  Cryptococcus neoformans
EKC97426            182 DEDdIEED--EMSLEHLGDVKASSI 204  Trichosporon asahii var. asahii CBS 8904
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