Conserved Protein Domain Family
SOCS

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pfam12610: SOCS 
Suppressor of cytokine signalling
This domain family is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam07525, pfam00017. The suppressors of cytokine signaling (SOCS) family play important roles in regulating a variety of signal transduction pathways that are involved in immunity, growth and development of organisms.
Statistics
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PSSM-Id: 403716
View PSSM: pfam12610
Aligned: 11 rows
Threshold Bit Score: 53.2732
Threshold Setting Gi: 429900745
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005474779  94 AASLLGQERVTAKPTLGATGSAAELPTSSegegRGSSSSRTLRQKIQDAMGQCFPIKTHTAA 155 Nile tilapia
XP_011608037  56 SCPRRRRERMCSCTTLGDGPASADNDVVC----RKALSRRSLRQKFQDAMGQCLPLRSHHHI 113 torafugu
ABQ28696      58 SCPRRRRDRTCSCAALGDLPSAADTDAVC----HKASSRRSLRQKFQDAVGQCLPLRSHHHA 115 spotted green pufferfish
XP_015206178  57 SCPRRHRETRCSCSPAGDGDCERP---SC----RKALSRRSLRQKFQDAVGQCFPIRSHHHH 111 spotted gar
CBY83941     133 RGSTARRERRYAVSSIQEINDSVEVGSS-----GRSLSSRSLRQRLRDTVGLCLPLPTHRRS 189 zebrafish
NP_001116396 142 RGSGNRRDRRYGISSIQEINDSVG---G-----GRSLNTRSLRQRLSDTVGLCLPLPARRCS 195 Japanese medaka
CAG10175     140 RGSGNRRDRRCGVGSFQEMSDGVC---G-----GRGLSARSLRQRLSDTVGLCLPLPAHRRS 193 spotted green pufferfish
XP_007255839 137 RGGTSRRERCYGTSSIQEMSDSAG-GVG-----GRSLSVRSVRQRLKDTVGLCLPLPTPRRS 192 Mexican tetra
XP_007231032 141 ERRSGRSRRRHGTSGISREELEPG-------------APRSLRQQFHDTMGLCLPLRSSSRN 189 Mexican tetra
XP_013132427  59 SCSRRRRERKCSCSALGDTLTSGDIDVMC----RKALSRRSLRQKFQDAVGQCFPLRSHHHH 116 Nile tilapia
XP_008570919  59 EVPLRNQERKHSCSSI-----ELDLDHSC----GHRFLGRSLKQKLQDAVGQCFPLKNCSSR 111 Sunda flying lemur
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