Conserved Protein Domain Family
CK1gamma_C

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pfam12605: CK1gamma_C 
Casein kinase 1 gamma C terminal
This domain family is found in eukaryotes, and is typically between 54 and 99 amino acids in length. The family is found in association with pfam00069. CK1gamma is a membrane-bound member of the CK1 family. Gain-of-function and loss-of-function experiments show that CK1gamma is both necessary and sufficient to transduce LRP6 signalling in vertebrates and Drosophila cells.
Statistics
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PSSM-Id: 403712
View PSSM: pfam12605
Aligned: 18 rows
Threshold Bit Score: 69.0845
Threshold Setting Gi: 74687548
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6C4I0       312 KpnlhgygHAYPPdrSGNAN----------SRQAHISSARlnatppp-----------------lpepaavARQNSKGRH 364 Yarrowia lipoly...
XP_023254013 314 K-------PLPTP--IGPVAsetp--lqtsNREKAPQ-TK---------------------------------NQSPEGK 348 Seriola lalandi...
XP_005451924 332 K-------SLPTP--IGPIPsdtp--vqpsSRDKAQQQTK---------------------------------NPSPEPK 367 Nile tilapia
4_pfamImport   1 K-------QLPTP--VGPIHadpa---lssNREAHQHRDKmqqakn--------------------qaiyvNETNSVEHS 48 
EDS32121     291 shivktksAKSTP--VGSLQtghev-vvspNRERHTPVNKdgdffsyydeel--------ddavtleimaqQQTNSKGGV 359 southern house ...
6_pfamImport   1 K-------TMSTP--VGSLQtgheivvspgNRDRHAAIKG----------------------------------GGVKGL 37 
EFN77420     263 K-------PMSTP--VGSLQtgqei-vvspNRDRHPAAYKeyddfeedvvlmmdevrfelqgqydvagggvGGGGGKGVG 332 Jerdon's jumpin...
EFX89320     312 K-------TMSTP--VGSVStnqev-iispNRERHPATNRvr---------------------------rvKASAASAGT 354 common water flea
XP_002403115 334 K-------QMSTP--VGSLQtgqev-ivspNRERHITTNA----------------------------------RSNPQK 369 black-legged tick
XP_005993849 332 K-------PLPTP--VGPVHndts---vppSREKTQQTKH--------------------------------Q----SPE 363 coelacanth
Q6C4I0       365 GARNpQARLSKNAQTPGYYqqSPSQSHGvqggagagtgamSSQQKQSSVHQQLSqSNQANYNQATDPA 432 Yarrowia lipolytica
XP_023254013 349 GSES-QPTPVTNRELLGSH--LTADRLG------------GSVQVMSSTNGELN-TDDPTAGHSNAPI 400 Seriola lalandi dorsalis
XP_005451924 368 GSES-QPTPVTNKETLGSH--LTAERLG------------GSVQVMSSTNGELN-TDDPTAGHSNAPI 419 Nile tilapia
4_pfamImport  49 STWS-LRSFQTRESHFTFQkqFPASK--------------GTAHVVSSTNGELN-TDDPTAGHSNAPI 100
EDS32121     360 AAWP--DVPKQTG-TLGNL--TPADRH-------------GSVQVVSSTNGELN-ADDPTAGHSNTPI 408 southern house mosquito
6_pfamImport  38 SAWP--DASKQGGHTLGNL--TPADRH-------------GSVQVVSSTNGELA-NDDPTAGHSNTPI 87 
EFN77420     333 ATWP--DTVKQSG-AGGTL--TPADRH-------------GSVQVVSSTNGELA-NDDPTAGHSNTPI 381 Jerdon's jumping ant
EFX89320     355 SGGP------GGNLLGGTL--TPADRH-------------GSVQVVSSTNGDLG-GDDP-AGHSHTPI 399 common water flea
XP_002403115 370 NAWL--DQGGGNPRQAGNT--LLAEKLGqpg------ppqGSVQVVSSTNGDLA-NDDPTTGHSNTPI 426 black-legged tick
XP_005993849 364 QVWDpQPGPQSCRENMGAH--LAADRLG------------GSIQVMSSTNGELN-TDDPTAGHSNAPI 416 coelacanth
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