6MJE


Conserved Protein Domain Family
Csm1

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pfam12539: Csm1 
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Chromosome segregation protein Csm1/Pcs1
Saccharomyces cerevisiae Csm1 is part of the monopolin complex. Csm1 forms a complex with Mde4 and promotes monoorientation during meiosis. Csm1 also plays a mitotic role in DNA replication. This family also contains the Schizosaccharomyces pombe homolog to Csm1, Pcs1. Pcs1 forms a complex with Mde4 and acts in the central kinetochore domain to clamp microtubule binding sites together. The two complexes (Csm1/Lrs4 and Pcs1/Mde4) contribute to the prevention of merotelic attachment.
Statistics
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PSSM-Id: 403660
View PSSM: pfam12539
Aligned: 67 rows
Threshold Bit Score: 82.1675
Threshold Setting Gi: 156219789
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6MJE_C        23 EIIKDLFEHLCGVRVHRTYEDDTGLWFDTSQGSKN-------GI----MDYKLGFVKsqaenTTEVd-TEVIYVPL---- 86  [Candida] glabrata
EEQ39330     259 GVTLDMLELLTGVRIISYEEDRVKFYFDVKQSSTNsdsdndaIS----VTYRLVIKR-----KFENt-AEVTYVPTffqk 328 Clavispora lusi...
EMG49204     114 SFTLDMIELLTGVKVINFENNSTEYVFDIRQTSSTnq----gLT----MNYQLVLPS--------EknPQISYVPTflda 177 Candida maltosa...
EER32159     157 SLTLDMIELLTGVKVVNFENTEDEYIFDIKQSSMK-------QEl--vVHYQLVLST------IPN--SEINYFPTflda 219 Candida tropica...
KHC76972     114 CFTLDMIELLTGVKVINFENTSDEYIFDIKQSSSVks----gLT----MHYQLVLASqp--------sPEINYIPTflda 177 Candida albican...
XP_001523381 135 CFTLDLLELLTGIKVTNFEESPTRYTFDIKQTSSN-------KEl--fIEYLLILSK------VDS--SQINYVPTfled 197 Lodderomyces el...
EGW33657     178 SITLDMIELLAGVRVVNFQEDDSMLYFDVKQSSPP-------LF----ITYQLIISK-----EFEAt-AQVNYVPTflda 240 Spathaspora pas...
EAZ62977     215 GFTLDMLELLTGLRIVNFEEDESKYFFDVKQSGSN-------GQdeiyINYQLVISK-----SFATt-AEINYIPTflea 281 Scheffersomyces...
XP_013937359 238 gTKLEITELLTGLTCQEYIEDSENMIFKMKQQGET-------CF----LIYQLLISK--------TgaGEIVYIPI---- 294 Ogataea parapol...
CAY67837     222 QIIFDMFELMTGVSCTDFEETNEQIVFTMRQSSVD-------STf---LMYKLSINK-----TTSRhiGEIEYHPI---- 282 Komagataella ph...
6MJE_C        87 LK------QRTAEELQel-----qKKLPDYLFETLSFPL 114 [Candida] glabrata
EEQ39330     329 MDes---pASEEEEIMnsharvlaPHLPEYLKDSLIFPY 364 Clavispora lusitaniae ATCC 42720
EMG49204     178 LD------GEEEEEIAnak--alkKKLSDFLCENLTFPF 208 Candida maltosa Xu316
EER32159     220 LE------GDEVEEYEntk--rlqKVLPEYLCENLSFPF 250 Candida tropicalis MYA-3404
KHC76972     178 LE------GEEVEDYEnak--ilqKILPDYLCENLSFPF 208 Candida albicans SC5314
XP_001523381 198 DGtrdsayKANQKNLV--------KVLPDYLCEYLSFPF 228 Lodderomyces elongisporus NRRL YB-4239
EGW33657     241 LEnef-dhGDDEVDIVenar-flkRILPDYLCEKLLFPI 277 Spathaspora passalidarum NRRL Y-27907
EAZ62977     282 LEn-----DDEDQEQVdnan-llkEILPDYLCENLSFPY 314 Scheffersomyces stipitis CBS 6054
XP_013937359 295 LKheesqsGSERKEWTenln-kleKVLPDYLLDNLTFPS 332 Ogataea parapolymorpha DL-1
CAY67837     283 FS------EQLQQDFEsv-----kSRLPDYLKDDLTFPY 310 Komagataella phaffii GS115
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