Conserved Protein Domain Family
Neuro_bHLH

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pfam12533: Neuro_bHLH 
Neuronal helix-loop-helix transcription factor
This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found C-terminal to pfam00010. There is a single completely conserved residue W that may be functionally important. Neuronal basic helix-loop-helix (bHLH) transcription factors such as neuroD and neurogenin have been shown to play important roles in neuronal development.
Statistics
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PSSM-Id: 403655
View PSSM: pfam12533
Aligned: 39 rows
Threshold Bit Score: 74.7146
Threshold Setting Gi: 341889755
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003222489 172 GKRPDLVAYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQgp-dLGGRYHggpgGGG-GgfgvGPHHPYG-YPC------ 242 green anole
XP_011661691 168 GVVPDNISFAQTLSRGLSQPTTNLVAGAMQLNPRTLLPDD------------------------QTSPYSaWPS------ 217 purple sea urchin
EGT45690      78 NEQPTPLQYAHTLANGLSQTTTNMLANLLQVQPRLLLPPSqf-dMFSDPT----SSSsTqhplHLHHSHPqQHS------ 146 Caenorhabditis ...
CAP38044      78 NEQPTPLEYAHTLANGLSQTTTNMLANLLQVQPRHLLPPSqf-dMFSDA------PLfPqhpqHLQNPPHhQSF------ 144 Caenorhabditis ...
XP_007242684 130 GTRPDLLAFARTLCAGLSQPTTNLVAGCLQLNAARFLADHggggIGEGE------AQ--------------YDV------ 183 Mexican tetra
Q9W6C7       137 GKRPDLLAFVQTLCKGLSQPTTNLVAGCLQLNARNFLTDHng-dVSFS--------GrPay----dSLYP-YPN------ 196 zebrafish
AAD23442     137 GKRPDLLAFVQTLCKGLSQPTTNLVAGCLQLNARNFLTDH----NGTCr---------Sla-gPRTIPCThTRT------ 196 zebrafish
ELW67941      47 GKRPDLLTFVQNLCKGLSQPTTNLVAGCLQLNARSFLMGQgg-eAAHH--------TrSpy----sTFYPpYHS------ 107 Chinese tree shrew
XP_005462360 148 GKRLDLLTFVQTLCKGLSQPTTNLVAGCLQLNTCSVISQPd---------------------eESLSLYAaYHH------ 200 Nile tilapia
XP_022529337 159 GKRPDLLSFVHTLCKGLSQPTTNLVAGCLQLNARSFVGEPg---ADSSFP----STR-S----PYDAVYAaYHGaeeaaa 226 Mexican tetra
XP_003222489 243 -------------------A----RLsgaqcGGGGGGGGGGSSSSHaLR----TH-AYC----AAsYEALY----GGNAS 286 green anole
XP_011661691 218 -------------------SapmnGM------TDSYGYDLSNTSSHhRLgenmTStGISnggpSSiHQLFLpsdgYCSSP 272 purple sea urchin
EGT45690     147 -------------------S-----------------------------------------------SSSFssptSSCSP 160 Caenorhabditis ...
CAP38044     145 -------------------C-----------------------------------------------PSSEsptsSSCSP 158 Caenorhabditis ...
XP_007242684 184 -------------------A---------------YGATPTGHAHHaGR--------------SSsVGTMDsgkpLRSTY 215 Mexican tetra
Q9W6C7       197 -------------------A----EMa----TPTGLSSGTRES-VKpFR----PY-NYY----AS-YESYY-----DSAS 233 zebrafish
AAD23442     197 -------------------P----KC-----HAHRPQLWDARKRQT-FR----PY-NYY----AS-YESYY-----DSAS 232 zebrafish
ELW67941     108 -------------------P----ELa----TPPGH--GTLDN-SKsMK----PY-NYC----SA-YESFY-----ESTS 142 Chinese tree shrew
XP_005462360 201 -------------------H-----------PGPEAGGSTTAGSGRsLR----PFgSFC----SP-FESLN-----DSSS 236 Nile tilapia
XP_022529337 227 aaaaaaaagvgagappiggH----HHh---hHPHHHHHPHHQDSAKsFR----PY-GYC----GA-YEAFY-----ESAS 284 Mexican tetra
XP_003222489 287 PDYNSSEYE----------G-PLSp-pPPLCVNGNFS 311 green anole
XP_011661691 273 PDLYHRQYD------------PSSataPTSSPSSTFS 297 purple sea urchin
EGT45690     161 PQYYYSPNQ------------PSA---APLQASLDLA 182 Caenorhabditis brenneri
CAP38044     159 PQYYYSPNQ------------PSA---APLQATCELA 180 Caenorhabditis briggsae
XP_007242684 216 GYCSTSPYEhgggyelggcGpRLE---PPLSYDGIFS 249 Mexican tetra
Q9W6C7       234 PESSSPHFD----------G-QMS---PPINYNGIFS 256 zebrafish
AAD23442     233 PESSSPHFD----------G-QMS---NPINYNGILS 255 zebrafish
ELW67941     143 PECASPQFE----------G-PLSp--PPINYNGIFS 166 Chinese tree shrew
XP_005462360 237 PESSGSLDM----------G-TLS---PPFNFSGLFt 259 Nile tilapia
XP_022529337 285 PECASPPFE----------S-ALSpppPPLSFSGIFS 310 Mexican tetra
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