Conserved Protein Domain Family
DUF3723

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pfam12520: DUF3723 
Protein of unknown function (DUF3723)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 374 and 1069 amino acids in length. There is a conserved LGF sequence motif.
Statistics
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PSSM-Id: 372162
Aligned: 28 rows
Threshold Bit Score: 501.01
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EJP69837      61 GETQNRIPAIISETELQDALAISNLTRgdlVARGDSF-----ARLDLPSAFQLKCLRGEDRVQAAREVLNSP-----EPR 130 
XP_001536438  63 LEPQHWIPAVVTRNGLQVILNANSLSS---IGGDDPGd----FPLSLPSGHEVTCLQGRIRHAAGTKWLETD-----DQW 130 
EMD97598      60 LDPENFVDALISRECFDTALFRKGITLeafKESCSTVddcvqTPIKLDLNTSIQCLNGLQRIRAAEAFLDNN-----DKW 134 
XP_003838685  62 LHDENILNAVVREDDLATALSRSNLTAaalRRIISATd---aPALHLE---KVSCLTGLHRIRAADRFLDPN-----DKW 130 
XP_001942238  61 LEEENVINAVIADEDLVAELSSQGKSIedfCNLQWPQd---aLDLPLE---YVDCLSGMHRIEAARRFLDEN-----DKW 129 
EOA84436      62 LQDENVIDAVVEDARLDAALRAIGLSIealQKVRSPKd---aPTLHLR---ELKCLNGLHRIRAADQFLDEN-----DKW 130 
EMD95298      62 LQDENVIDAVVENDRLDAALRAIGLSIealQNIRSPKd---aPTLNLR---ELKCLNGLHRIRAADQFLDEN-----DKW 130 
EEH06960      62 LQPENYIPAVVSHEDLANALQLSEISQgdlLQDGEP------HTLELPLGVSITVIHGKHRLLAAKQFAVDKfllesEQW 135 
EED21208      57 LDPWNHVPVAIDRNTLSARLRLAGLDNddlIREGEP------PLLRFTT--PLRVLHGRRRLLAAEEYLW-------DKW 121 
EDN08139     116 EDPENYVPVLISQNTLSQAIDDSRTTQvvlLNGIEP------PNLILGHGTRLLCLQGKSRIRAAQEFFSPG-----ERW 184 
EJP69837     131 WVVDLYAA-----------------DISDETRRDLAEEYACEQAPADGDFYFKIREYQgvfGQENSRAEDTWKARLgats 193 
XP_001536438 131 WILKLYDS-----------------RLSSEARRSLREDRDASQEFSSGEIYWNVRHHE---RQGNDDERRKWLARWp--- 187 
EMD97598     135 WIVNLYEDa----------------TFERTLETHLYESYNHEQQYTDGIIFRNIRRYA---RVHDTENEKKWWARL---- 191 
XP_003838685 131 WTVRLFSN-----------------DTPQPVLCHIIESYANEQKPRDGDIFRKIRYYH---REKDAEAENRWWARL---- 186 
XP_001942238 130 WVVRLFSH-----------------NTPKPVLAQIIESFANEQKPSDGEVFRKIRLYH---RENDEEAQKRWWSRL---- 185 
EOA84436     131 WVVRLFSS-----------------ESPTPILFHMVDSYINEQKPSDGEIFRRIRLYR---LENKVEAERKWWARL---- 186 
EMD95298     131 WVVRLFSR-----------------ETPTPILCHIVESYKNEQRPSDGEIFRRIRLYH---RENKVEAERKWWARL---- 186 
EEH06960     136 WVVKLYSD-----------------SLPAPARSAVREEYSHTLQFCDGDIYRSWRFYQ---TQGNVEEAARWLARL---- 191 
EED21208     122 WIAELYSDgdyqttyiivlninlyeDLPAKLKTSICEQYSHSRPFCDGDIYRHIFKYQ---RDGNIDEEEKWIRRL---- 194 
EDN08139     185 WGARLYLD--------------------TAARDRLREKYSNEQNFGDGDIYRNLRYHQ---LRGNGPRAEAWWARW---- 237 
EJP69837     194 gSGHKKNRMDQI---VTDPRLCVAFDAFRRIPVLYGDLKLS---------LVNKMTSMGCHEESLHYLNHIKDFWHSVFD 261 
XP_001536438 188 -SPYMERDFTQLresIYSRPLYEALDRLLEFRALWPAFHVG---------NLHRLLPMRCPEALASYLDFIRDVWMWITD 257 
EMD97598     192 -TATKRKDLAQL---LSNQKLSLAFDALIDYAGLWTPIRLG---------TLHRFHALKCTKELKSYLRHIHTVWDSLIP 258 
XP_003838685 187 -DKSKPKDLRQL---LKRHKLASAFDALIDFPGLWAKIQLG---------ALHRLLTLKCDEEMIRYLNHVALTWTTILK 253 
XP_001942238 186 -EKSKPKDLRQL---LRRPTLIAGFDALIDMPGLW-------------------------AKEMALYLDYIAKAWSKILR 236 
EOA84436     187 -DNSKPKDLRQL---FKRREIISGFDRLLEMPGLWAKVQLG---------ALHRLLTLKCDEEMANYLSHISKVWTKILT 253 
EMD95298     187 -DNSKPKDLRQL---FKRTEIISSFDKLLEMPGLWAK-------------------------EMAYYLNHVSKVWTKILT 237 
EEH06960     192 -SPRKRADVQQLq--IKHHALSRGFDQLLPFIGLWPKLEIVprydasfllLLNR--SSQPTQALLHYLDRMHSMWSVILG 266 
EED21208     195 -SNSKTMNVRQLr--TKYRRLANGFDRLTPFVGIWYQLHLG---------CLSRLLPDKTPEEFLHYLERMRHQYSSIMG 262 
EDN08139     238 -SSPKRRHVRQM---QKQERLLNQFDRLLPYVGLWASVNVK---------LFRRIVDSRCYEESINYLDQTFKVWSVL-P 303 
EJP69837     262 GNEsa--mMKLDRTSLEALQLTAPGACEKQARDLHARIRSGDILSAFTEAE-RERIWSKIYDAtvDCTVPSLHSFFEDRK 338 
XP_001536438 258 SRP-----WRLEETDVEHLEGRSPMWSKADGIYIDEVFKDGTVFCRIINQDeREVLRQRVRQC--STIIPSIRTFLEDSK 330 
EMD97598     259 NEHrv----hVDSRTVSMLEMLAPSVSTRDAARARQLMLDGCIFPQLEDIHaRNEILNRIQSQ--KCMIPSLRTFFEDQK 332 
XP_003838685 254 YESttmspSIVDAVTVNHLELLAPNHSKIDRDLLLDLMDRQILFPSVIDNQqRRALASNLCAT--IGLIPSLWTFFEVLK 331 
XP_001942238 237 CGErtlpfSIVDAVTVQNLQLLAPAHSDMDKNLVIELMERRDIFSSLKSGTiRRTLTDNLCAF--PGVIPSLWGFFEMLK 314 
EOA84436     254 CRNvtlpfSAVDTITVESLESLAPKHSSIDKAYVLDLFKRNIIFPSQLDSGiRQELAENVCAS--EGLIPSLWTFFETLK 331 
EMD95298     238 CRNitlpfSAVDTVTVDNLESLAPKNSSVDKAFVMDLFERNIVFPSLLDSQiRRELAENICAS--EGLIPSLWTFFETLK 315 
EEH06960     267 DQRys----lVDQGTVALLETMAPGDANADAALIQDRMSRREIFPAIDEQYeRDAILQNILGI--NGRILSFNTFFQDLI 340 
EED21208     263 TEEpf----lLDPKTVYLLETMFPALSVSDADHIKRLMNDGVLFPAVQSQHrRKKLLDNILGV--KGRILSFYTFFQDTI 336 
EDN08139     304 HDAaa----lVDAQSVHLLEGLMPAYSLVDQKRIQDLMNNREIFPALIDSErRSKVLERLLQV--SGRILSLHTFSQDLL 377 
EJP69837     339 YIEDAAHCMKRLFPGKLHETIRSALESAYPDvdDQGTECLVQVSNSSYAMVAt---NGADHFDLAYRQLWLYARRH-FED 414 
XP_001536438 331 YLEPMAKLVRMLLPPDFKGTVQEGMRRCYQP--SANGVLHIQTSAAGHRTAPr--dADDDGFWSAYRQVWLGAMRDwFGI 406 
EMD97598     333 YLEPCSKILKQLLGVKSKRPIWKEFKANYWE---HESEIKVQISETKNLPLPgs-lGKKERAKLGYLQLWMFCFRH-WPE 407 
XP_003838685 332 YLEPMCEILKDLIGGKQKRTIHSSLMANYYP----PATPMVQISDTTEAEITip-lSKAEAAKVSYIELWAFCGRH-FDG 405 
XP_001942238 315 YLEPLAEALRHLLGKDMKRTIRSSLMGLYFA----PSKIMVQTTETQDVEIKva-lSRKQAGMIAYTELWAFCGRY-FDG 388 
EOA84436     332 YIEPICEILKKLVGSNMRRTIRSSLMGHYFP----PERRHIQVSKLREAEITsl-lSREEAAWISYVELWAFCGRY-FAK 405 
EMD95298     316 YIEPICEVLKKLIGGNMKRTIRSSLMGCYFP----PEKRYIQVAKFREAEITsl-lSQEEAAWISYVELWAFCGRY-FNK 389 
EEH06960     341 YLEACVNSLCFLLPSTFPGSLRDTFTGVNQV----AGEIRVQTRDHGMVVWPnergEWDQCRELGYQQLILAAMRD-FPS 415 
EED21208     337 YFGACSKILRNLLPPKFQGTVRQAFFNSYQQg-INQGRIRLQSYGERMLDRPg---TEVTHVQLAYRQLYLAAMRD-FPI 411 
EDN08139     378 FLELPSKALRGLLPKTFKGSVRNALLKKYVH---TENSYIIQTSAAGYRIAAg---TLKAASYLSYVPLWLCAIRL-F-- 448 
EJP69837     415 MPPEREHI-----------------VAGYKTAGVDEMVLFDFASLAYKLGFRTTEIKKLLQGn--pDRQI-AHRLLKMAR 474 
XP_001536438 407 VPGFRPRKmt--------------kVPGTVAQPHPSILWSRFVDLAVSVGFNISKRPDFSES----PEDI-IRQCLSLLR 467 
EMD97598     408 MTSFTPRLesglkitdeadmrnievRPKSARRDHNPALWQRLACLAMQVGFETSNICKLAGEd---aEMVqAKQFLNSAR 484 
XP_003838685 406 LTAFTPRKei--------------nGTKPLVKGPNSVLWHHLAKFAVSRGFKTKRAQELAATd--pYTQL-AREYLYKAN 468 
XP_001942238 389 LTAFTPRKet--------------gEPKPTVNGPNPVVWQHLARFAVSRGFQIPHAQALVADegrlRSQL-ALEYLHKAR 453 
EOA84436     406 LTSFTPKKes--------------gEVKPVVEGPNPVLWRHLANFSVSRGFKTKPAEKLANSd--pYTEL-AHEYLRKSS 468 
EMD95298     390 LSSFTPKKes--------------gEEKPIVEGPNPVLWQHLADFSISRGFKTKSAQKLANSd--pYTEL-AQEYLRKSS 452 
EEH06960     416 LSQIAPRRdq--------------gKPASVVDSPSEECRQGIANLAFNLGFETSEIRNLRAVd--pTRDL-ASKFLSRAR 478 
EED21208     412 LSSLAPLWds--------------kKRRPLIQGSPSERWHQIASLAFVLGFRTDEIAKLMEDg--nNKEImAREFLTKIR 475 
EDN08139     449 ---VSPLKds--------------hTSEAIHTFSSIRGLPFLADEAISLGFSSTEIKKLSNQd--aNEQT-CRYFVEHMC 508 
EJP69837     475 KPDQFYFED--IESSISAVTTVMEAARPICNSQDv-DVEEPEVVAAGATAKQCGRPLVSDHMRCKPLLFLDKLH-ATMAR 550 
XP_001536438 468 PADLFEQDPdlLSAESRRVAENLGFRRRPAEIARpaRPSLTTDLGAWSITARCGMTDGASFFSDQKYLFLDNIYaRLDDV 547 
EMD97598     485 PE-----WEsnRSDCERKIADILKSMQGTSSQKPqtPIWVDDGVMSWPREKRCGKPHEADHEHDKSVMFATMFY--HPLQ 557 
XP_003838685 469 P-----ICAspKDSQVRRVVHASYPEVNIRGPET------LPEALHITKERRSGRTFESDLEYDKKLLFLPHVY---GSD 534 
XP_001942238 454 P-----TCPtfSDNDVRKVLDAVPVDMDISQHQS------PLPLPHLSIDRRIGRPFAGDFAEEKRLLFFPHLY---GPV 519 
EOA84436     469 P-----LSSlsCERQIQEVLRASRIVDDDSQQPQ------SVLSGHLEKERRSGRPYENVLRMDERNLYLPNIY---NSE 534 
EMD95298     453 P-----LSSssHERQVQEVVRASRIVEDDSQQPQ------LVASGHLEKERRNGRPYENDLRMDEQNLYLPNIY---NSR 518 
EEH06960     479 PPEFYDLDEnlVNDIVSYIAEHLPRAARLRPLNR--PPEFTTNLLSQPKDDRCNRPRHAAYKNDREYLYLDVIY-NYQPT 555 
EED21208     476 PAELYIVDEgrKERLVQYIARQIDGIATPRVLRQ--DAEFTTNVEGLAKEQRCNRPYDSAYRRDKDFLFINIIY-GTRIR 552 
EDN08139     509 QVELYEPEPkrLSDAVRRIQNTLKQLQEKRKIADg-VPVFSKNATSEPLCRRYNRPLASHLESDRCYFFIEHIY-GTDQS 586 
EJP69837     551 QNRNLSSFFIQRSTYFAFFG 570 
XP_001536438 548 PGVHLTSFAVKRDFFLAHFP 567 
EMD97598     558 SSQTITSALVKRNVLEAFFd 577 
XP_003838685 535 NPEEASLRLSRRYLFSTLFG 554 
XP_001942238 520 VFENASISLMRRDLFSCIFG 539 
EOA84436     535 EPVEANWTLIRRDMFHSLFG 554 
EMD95298     519 EPTEAGWTLIRRDVFKSLFG 538 
EEH06960     556 GGSHLTSLAIQRDIFVSFFS 575 
EED21208     553 AQAFITSLAIQRDIFICFLG 572 
EDN08139     587 IAHHPTSIAVTREIIFSFFG 606 
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