Conserved Protein Domain Family
BCAS3

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pfam12490: BCAS3 
Breast carcinoma amplified sequence 3
This domain family is found in eukaryotes, and is typically between 229 and 245 amino acids in length. The proteins in this family have been shown to be proto-oncogenes implicated in the development of breast cancer.
Statistics
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PSSM-Id: 403626
View PSSM: pfam12490
Aligned: 29 rows
Threshold Bit Score: 174.45
Threshold Setting Gi: 229284200
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_795856    277 PQTVTILPLEQIKLStTlGAVATSMAA---STAKPgRGKAp----TQSSGAsey----sgLATCFALS-----RGHVQGA 340 purple sea urchin
EEN54937     483 PHPTVVTPAAQIKQPlVlSG----------ISSSStAGKSp------THGSpikqdnvlcVAAQFASS-----RGWRMGN 541 Florida lancelet
EEF39532     521 GPPVTLSVVSRIRNG-N-NGWKGSVTG---AAAAA-TGRL-----SSLSGA---------IASSFHNC-----KGNNDLY 575 castor bean
KRH22234     546 GPPITLSVVSRIRNG-A-NGWRGTVSG---AAAAA-TGRK-----NALSGA---------IASSFCNY-----KGN---- 596 soybean
KRH25883     531 GPPITLSVVSRIRNG-S-NGWRSTVTG---AAAAA-TNRM-----SSLSGA---------IASSFRNF-----EGNSTLF 585 soybean
CAN75263     520 GPPVTLSVVSRIRSG-N-NGWRGTVTGaaaAAAAA-TGRM-----SSLSGA---------IASSFHNC-----K-ANDLF 576 wine grape
XP_006363523 517 GPPVTLSAVGRIRSG-G-NGWRNTVTG---AAAAA-TGRT-----ISFSGS---------IASAFHHC-----NSTR-QC 570 potato
Q9FH32       440 dAPVPMSAISRIRSG-NsSGWIGTVSG---AASAA-AGMVa----GSVPGT---------VTSTFCYCdeksnNNY-YGS 500 thale cress
XP_009132428 442 nAPVPLSAVNRIRSG-NiSGWMGTMSG---AAAAA-AGMVg----GSLPGA---------TASAFCYSveqdkNNHLYGS 503 field mustard
XP_009127070 452 hiPVTLSPVIRIRSR-DiSGWMGTVSG---AAAAA-AGMVgggggGSLQGS---------TTSTFSYCveqqnKNTHYGS 517 field mustard
XP_795856    341 NQVPReKdst-rvsPIPSLFIMSCHGFLVEYTLDPKATLPA----------SVKKGDDSPLELVASMVAQWRLQRGFNSP 409 purple sea urchin
EEN54937     542 PTASReKadpgkplPVDSLYIISCHGNLMEHVLDPQPVD------------SIPKMDDAPIQLLTQPLAQWNLKRCSTSA 609 Florida lancelet
EEF39532     576 LDGTIlK-------SKYHLLVFSPSGCMIQYVLRISAGIDSmavvp-glgtAFESVPESDGRLVVEAIQKWNICQKLNRR 647 castor bean
KRH22234     597 -EGNFsK-------AKYQLLVFSPTGSMVQYALRTITGQDSavvs--glspAYESIPQADTRLVVEAIHKWNICHIR--R 664 soybean
KRH25883     586 VNGNYsK-------EKCHLLVFSPTGSMIQYALQTINSQDSgvvs--gvtpAYESAPATDVRVVVEPIKKWNISQRQSWR 656 soybean
CAN75263     577 SNSSSlK-------EKYHLLVFSPSGCVIQYALRISTGIDSttvvs-glstGYESTPDGDGRLVVEAVQKWNVCQKQHRR 648 wine grape
XP_006363523 571 ADSGLlK-------ANHRLLVFSSPGCMTQYALRMCSELDSvatvp-amgsTYEADLE--TKLVVEAIQKWNIFQKQNYK 640 potato
Q9FH32       501 VA--DmC-------SKTNLLVFAPSGCMTQYALREHQVG-VghetaamtgfDSESGLETEGKLAVDPIRRWSMIQNQSRR 570 thale cress
XP_009132428 504 SAASDnS-------LKRNLLVFAPSGCMTQYALKANQVGDGghem---agfDFESGSETEGKVGVEPIRRWSMIQNQSRR 573 field mustard
XP_009127070 518 TASDNsS-------VTRNLLVFAPSGCMTQYALKAGEGGEAlvm----tgiDSESGAETEGPVV--RIRRWYMVQNRSRR 584 field mustard
XP_795856    410 ECNLRIPgNSLVH--LFSDDAERSitatqgslyQSLPRNESCESltsahSSNQDTDfDEPWLSQVE-MVTHAGpHRHLWM 486 purple sea urchin
EEN54937     610 ELKPPLPsNSPLIiaADIVAADNAa-------sMSNSMVTRYDSydslsSDQSSQE-DDHWLSQVE-MVTHAGpHRRLWM 680 Florida lancelet
EEF39532     648 ERED----NVDIY--GENGISDSNkiyp-egkkKGNSVHPEGMGatikeKINPEEK-HHLYISEAE-LQMHQP-HTALWA 717 castor bean
KRH22234     665 ERED----NVDIY--GENGISDVNkiypeevreKIDTISPKIKNgvmkvNPCLEEE-HHLYISEAE-LQMHQA-QTPLWA 735 soybean
KRH25883     657 EGED----NIDIY--GENVVSDSNklys-eevkKDNIISPKMKNvavkwNSCSEKE-HQLYISEAE-LQMHQA-KTPLWG 726 soybean
CAN75263     649 ERED----NTDIY--GENGNTDSSkifp-egikKENAFHPETRSgvsksKISPEER-HHLYISEAE-LQMHQA-QNPLWA 718 wine grape
XP_006363523 641 ERDD----NADIY--GEFGCSDSSkvfp-egitKGNSLSSETRNtftkeKIRSEIG-HHIYISEAE-LQMHRP-HNQVWA 710 potato
Q9FH32       571 ETHDP---HSDIYg-GGTSVDSKSkvfpevvrkQSVEEA-WKVSkkgttR--VVDK-RHLYIYEAEqQQTHLPtQLPLWA 642 thale cress
XP_009132428 574 EMQDQ---HSDVYg-GGASSDSKSkvfpeivrkQSADES-WKVTkkgkaR--VEDK-HQMYMSEAE-LQMYEPtQLPLWG 644 field mustard
XP_009127070 585 EMQDQ---QRDVYggGGATSGSGSnvfpeivrkESAEEEPWKANkkgkaRRVVDNN-HQLYVSQTE-LRMYQPsHLPLWE 659 field mustard
XP_795856    487 GPQFVFKTVPQPSSTtilssSSSAllteGletnrsamDMTIDDMDLRSLRI 537 purple sea urchin
EEN54937     681 GPQFSFKTFQTNTAVls--sNSSAllgqSpda--ntvDVLAEELDLQSLRQ 727 Florida lancelet
EEF39532     718 KPEIYFQPMMTEGIKmdgenAM-L----G--------EIEVERLPTRTIEA 755 castor bean
KRH22234     736 KPEIYFHSMLQESTImdeeaAASG----G--------EFEIERIPTCMIEA 774 soybean
KRH25883     727 KTGIYFHSVGKEAILmmdeeAASG----G--------EFEIDKIPTRVIQA 765 soybean
CAN75263     719 KPEIYFQTMMVDGLEe---nVL-G----G--------EIEVERFPTRMIEA 753 wine grape
XP_006363523 711 KPEVFFRSFVMDRIHld--dEG-G----G--------EAEIEVIPTHIVEA 746 potato
Q9FH32       643 RRKFRFQELVLNRGEeisggG--G----R--------EMEIEGIQTRTIEA 679 thale cress
XP_009132428 645 RRNFRFQEWVLDVDEesnggG--G-------------EMELEGIQTRTVEA 680 field mustard
XP_009127070 660 WDNCRFEKLVLDVDEes----------nG--------EMEIEKIKGQTIEA 692 field mustard
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