Conserved Protein Domain Family
SLY

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pfam12485: SLY 
Lymphocyte signaling adaptor protein
This domain family is found in eukaryotes, and is typically between 144 and 156 amino acids in length. The family is found in association with pfam07647, pfam07653. There is a conserved LGKK sequence motif. SLY contains a Src homology 3 domain and a sterile alpha motif, suggesting that it functions as a signaling adaptor protein in lymphocytes.
Statistics
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PSSM-Id: 403621
View PSSM: pfam12485
Aligned: 29 rows
Threshold Bit Score: 100.111
Threshold Setting Gi: 512842874
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011217009   19 KRSSSFGNFDRFRNNSI-SKPDDSTEVYEGe--PINETGEQNKTSNG---GGLGKKMRAIS-WTMKKKVGKkYIKALSEE 91   giant panda
XP_005992037   21 SLQRSNSFKDFMKSKPSsPLVNDKPFALDEnipETEAVCVEGEDPGKa--SGSKLGKKWRAvISRTMNRKMgKMVGKALA 98   coelacanth
XP_015207271   21 SLQRSSSFKDFMKHKPSsPV-VDKEGPLDEsilEADGH--HPEESGK---SSGKLGKKWRAvISRTMTRKTsKMVQKALA 94   spotted gar
XP_004073141   21 TLQRSSSFKDFIKNKPTsPVASDKEFTLDE----SVAENGTAEEAVK---SGSKLGKKWRNvISRTMTRKTsKMVQKALA 93   Japanese medaka
XP_001521259   34 SLQRSSSFKDFAKSKPTsPVVSEKEFNLEEnipEDDSKIPITEENGKg-gSGKKLGKKWRAvISRTMNRKMgKMMVKALS 112  platypus
XP_003262358   21 SLQRSSSFKDFAKSKPSsPVVSEKEFNLDDnipEDDSGVPTPEDAGK---SGKKLGKKWRAvISRTMNRKMgKMMVKALS 97   northern whit...
XP_001373751   21 SLQRSSSFKDFAKSKPSsPVVSEKEFNLEDnipEDDTGGPITEDAGK---SAKKLGKKWRAvISRTMNRKMgKTMVKALS 97   gray short-ta...
Q28HN6         19 KLQRSSSFKDFGKSKPSsPVVSEKEFNLENdipEDEAGVTADENKq----SSGKLSKKWRAvISRTMNRKMgKEVMKAMA 94   tropical claw...
XP_005046272   20 SLQRSSSFKDFNKSKVSsPV-SNEEFNLEEnipEDEPG---PEEAARs--SGTKLGRKWRAvISRTMNRKMgRMAVRALA 93   collared flyc...
XP_007252036  529 yHGRACSFGGFDLVNRSiYMRENSCDPNIE-----SGDSIRRDTTRSptpSRISLGKKVKS-VKETMRKRIsKKYSAALS 602  Mexican tetra
XP_011217009   92 KD--EEDGENALPYRnSDpMIGSHTEKVSLKASDSMDSL--YSG---RSSSSGI-TSCSDGt--sNRDSFRLDDDGP--Y 159  giant panda
XP_005992037   99 EEmnENMEEGSMSPAtPD-EDVERRISGKMPLCFRDSEE--DLHsplSRQVSSGsELQSP-----LSNRDSIRLEDMp-P 169  coelacanth
XP_015207271   95 EEgvESGEEGSMSPMsE--GLPDLRMAERTSQCSFDSEE--AVPsplSRQLSGCgDRHSVDs--gCSNRDSMRLEDN--- 165  spotted gar
XP_004073141   94 EEggESGEE--LSPVsVD-WLPDLSAGQRTSVCSTGSED--TTPspiSRQLSASsDRQSLDs--gYSQRDSMRLEENg-I 165  Japanese medaka
XP_001521259  113 EEmaDTQEEESISPTsPD-CETEGLSHEKVAMCYLEQEE--DTRqplSRQTSTGsELCSPGyssiSRDRGSL--EEAs-L 186  platypus
XP_003262358   98 EEmgDTLEEGSASPTsPD-YSLDSPGPEKMALAFSEQEE--HELpvlSRQASTGsELCSPSpgsgSFG------EEPpaP 168  northern whit...
XP_001373751   98 EGmgDPLEEGSASPTsPD-CPLEGLASEVMPLAFTEQED--GGHlalSRQTSTSsELGSPGpgtvGCGQTSLRVEELmaP 174  gray short-ta...
Q28HN6         95 HEigEP--TGPSSPIsTD-GSIDGMHRKS-----SDPEE--NLHspvSRQTSSGsEVFSPSf--mINNRDSINLENLp-P 161  tropical claw...
XP_005046272   94 EGkgEGQEEGSPCPLsPG-SSVEEQSRDKVPLSYLELEEeqDGRpalARQTSSGsDAPSP-----TEPGDSKRLEEAv-P 166  collared flyc...
XP_007252036  603 EQssPSREPGSPQSPhT-----HTDSLEKPKLKAGGSVE--SLRsslSGQSSMSgqtvsttdssasnresvksedgddde 675  Mexican tetra
XP_011217009  160 SGPFCG 165  giant panda
XP_005992037  170 SYTGPF 175  coelacanth
XP_015207271  166 -YTGPF 170  spotted gar
XP_004073141  166 SYNGPF 171  Japanese medaka
XP_001521259  187 PYTGPF 192  platypus
XP_003262358  169 QYTGPF 174  northern white-cheeked gibbon
XP_001373751  175 MYTGPF 180  gray short-tailed opossum
Q28HN6        162 PYNGPF 167  tropical clawed frog
XP_005046272  167 AYTGPF 172  collared flycatcher
XP_007252036  676 lpyrgp 681  Mexican tetra
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