Conserved Protein Domain Family
PE_PPE_C

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pfam12484: PE_PPE_C 
Polymorphic PE/PPE proteins C terminal
This domain family is found in bacteria, and is approximately 90 amino acids in length. The family is found in association with pfam00823. There is a conserved SVP sequence motif. There is a single completely conserved residue W that may be functionally important. The proteins in this family are PE/PPE proteins implicated in immunostimulation and virulence.
Statistics
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PSSM-Id: 372141
View PSSM: pfam12484
Aligned: 89 rows
Threshold Bit Score: 28.819
Threshold Setting Gi: 444893863
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
MSJTU:JDM601_4196 301 AASAGQ-ASMVGSLSVPASWATAApAGKA--LPAAL---SGSPASAGAAAFAVEgsstamfnemalsslagralgGTAVQ 374 Mycoliciba...
WP_012393739      182 VAGVGG-VSAMSAASASPSWAGQAtLVSS--TSAGAlrgAGWTVPAPQAAPGTVi-------------------pGMPGL 239 Mycobacter...
Q79FA8            193 AAGLSR-ASSIGALSVPPSWAGQAnLVSS--TSTLQg--AGWTTAAPHGAAGTVi-------------------pGMPGL 248 Mycobacter...
WP_003405370      192 AAGLGS-ASAIGMLSVPPAWAGQAtLVST--TSTLPg--AGWTAAAPQAAAGTFi-------------------pGMPGV 247 eubacteria
Q79FA9            311 TASLGE-ASSVGGLSVPAGWSTAApAMTS--GTTALe-gSGWAV-PEEAGPVAAm-------------------pGMAGI 366 Mycobacter...
WP_012393740      311 EAGLGQ-AAGVGKLSVPVGWSSAApALTS--GTTALd-gSGWAV-PEESGPIAAm-------------------pGGPGM 366 Mycobacter...
P9WI31            309 gASLGE-ATLVGRLSVPAAWSTAApATTA--GATALe-gSGWTVAAEEAGPVTG---------------------MMPGM 363 Mycobacter...
VBC:MMAR_4452     307 GAALGE-ATLVGKLAVPTSWSSALpETAA--TTGALg-gSGWTV-PEEAAPVSGv-------------------aGVPGM 362 Mycobacter...
Q741T4            610 SAAVGE-ASAVGGLSVPASWSAAApATSLasSAAPLe-gSGWTV-ASEAEPVTAm-------------------pGMPGA 667 Mycobacter...
MSJTU:JDM601_0996 191 SAGAGQpAARTTGAPLPPAWAGEPaPASA--TPATL---SGTSTAAAAPRASTAav-----------------paGLPAS 248 Mycoliciba...
MSJTU:JDM601_4196 375 SVAGGAA-----------------RV 383 Mycolicibacter sinensis
WP_012393739      240 AAATRNSagfgapry-gvkpivmpKP 264 Mycobacterium marinum
Q79FA8            249 ASATRSSagfgapry-gakpivvpKP 273 Mycobacterium tuberculosis
WP_003405370      248 ASAARNSagfgapry-gvkpivmpKP 272 eubacteria
Q79FA9            367 SGAAKGAgayagpry-gfkpivmpKQ 391 Mycobacterium tuberculosis
WP_012393740      367 AVAGKGGgfagpryg--fkptvmpKQ 390 Mycobacterium marinum
P9WI31            364 ASAAKGTgayagpry-gfkptvmpKQ 388 Mycobacterium tuberculosis H37Rv
VBC:MMAR_4452     363 AAAAKGAgayagpry-gfkpivmpKQ 387 Mycobacterium marinum M
Q741T4            668 AAAAKGAgaygsgprygfkpivmpKQ 693 Mycobacterium avium subsp. paratuberculosis
MSJTU:JDM601_0996 249 SSEQGSRgrlrygi----kpkvmpRP 270 Mycolicibacter sinensis
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