Conserved Protein Domain Family
GIDE

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pfam12483: GIDE 
E3 Ubiquitin ligase
This domain family is found in bacteria, archaea and eukaryotes, and is typically between 150 and 163 amino acids in length. There is a single completely conserved residue E that may be functionally important. GIDE is an E3 ubiquitin ligase which is involved in inducing apoptosis.
Statistics
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PSSM-Id: 403620
View PSSM: pfam12483
Aligned: 23 rows
Threshold Bit Score: 101.681
Threshold Setting Gi: 261835105
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Cyan7425_1067  95 EERLTERDNDgetrektQRGSETIASNSQSTPFFLQDqS-GAIEV--DPSGAAIETVQVLNEF----RP-EA-GSARISF 165 Cyanothece...
Q8DMC2             88 ISREYEKEGS-------DRPSEIIGRHEQSTLFLLRD-HqGEIEV--NPFGAEIEAVQVLDEL----RPaDQpHAFALSL 153 Synechococ...
Q8DL39             91 VYKTTESHEDgss--etKYRHEILSSNTQTIPFRLRD---GDMEIyvDPRGAEIETVQVLNEFq------EDnNTTHLAF 159 Synechococ...
WP_015954732       93 NEEVIKQDNEgktirekERKSETVAQNSRSIPFTLQDsT-GEIRV--NPERAEIETVKVLEEF----RPeNF-SGGSLTF 164 Gloeothece...
tgen:AM1_3710      93 EEQVTERDSDdkvvtktQRGSETLSQNRESVPFFLQDdT-GEIWV--EPEGAQIETVRVLDEF----SPeQP-SGGQLSF 164 Acaryochlo...
Q31N13             95 EERVRKEDSEgkvtwttERRSETISQNRRSTPFYLRDqH-GRVRV--EPESAAIATIPVLDEF----RP-DS-SASSLIF 165 Synechococ...
WP_012795982       94 YEVIEYRDGKrh----rRKRTERVAEHTSAQNYAVIDeE-GRTIGvdPNGTKPDSVEQTVSRF----EPhRGnSQSIELF 164 Saccharomo...
Q1ATI9             83 VVREYLERDRgdgapgsGRRSEVLARSERFAPFVVEDdT-GGVPV--SAEGAEVDAKKVVDRF----ERgAGaAGLSVTI 155 Rubrobacte...
jgi:Sthe_2360      86 EYEYRRRNAKget--vrSRRSETVAHNEQFTPFYVED-SsGRVLV--DPEGAEVDAQKLVDRF----ERnPGaLGPTISL 156 Sphaerobac...
jgi:Caur_1130      93 EERITTQESGrst-triERRSEQLEQNERRVPFTIRDdT-GQVLV--VPDGAKIDLIETANRFletpQPwTGaTR----- 163 Chloroflex...
jgi:Cyan7425_1067 166 GNFSLSVggsFPagreTIGYRYRESILPPDRRILIVATA-SDSSGILSLQKPVEKRQ--KFIISLKSEDHLAQSTQQTAT 242 Cyanothece...
Q8DMC2            154 GFLSFNWhfgKGt---TLGYRYQEWVLPLGQPVSVVGMA-SDQGGVLRLQKPQNRGQ--KFIISLSFEDPLIQQYKQQKR 227 Synechococ...
Q8DL39            160 GRFQMDLsslPKhs-dTVGYRYEEWILPVNQQVFVVGTA-SDERGKLRIRRPHQKGQ--LFFISLESEENLTKKVRQYAR 235 Synechococ...
WP_015954732      165 GNFSINLp-sFEerrqTIGYRYQEEILPIGRQILVIGTA-TDEEGMITIRKPTEKGQ--RYFISLKSEEELSQATNNAIR 240 Gloeothece...
tgen:AM1_3710     165 GGFSLSLs-sAEtgrqTIGYRYQESVLPVQRQVFVVAQV-SDFNQSLVLENPTTKGQ--RFVISLKSEEALAQTTQTSVT 240 Acaryochlo...
Q31N13            166 GAFSLSLs-tTAglgkTLGYRYREEILPCDRSVLVVGAA-SDETGELTLGPSSEARQ--QFFIALKPETALLQEVKQTIQ 241 Synechococ...
WP_012795982      165 GFKLPTMlgrGDs---TIGYDYKEWVIRPGQRLYILGEV-HDRFGPLMIGKPAQ-GG--HFIISTRTEEELRASRVKRHK 237 Saccharomo...
Q1ATI9            156 GGATIDLgggER----TLGYRHTEEILPVDAPVYVLGAVrRDG----GIGPPEEGAG--RFVVSWRSEEALGESLGRGAR 225 Rubrobacte...
jgi:Sthe_2360     157 GGISLNLggdDG----TIGYRYQEHVLPVDIPVYVLGVVqEGG----TIGRPPAALKgrRFIISYRAEEALRESWGKKAR 228 Sphaerobac...
jgi:Caur_1130     164 ----------------TLGQRQFERGLEVGIRVFVSGTAiDQNGQVVIARHPTNSKQ--TFIISRKSEHELANSAATWAR 225 Chloroflex...
jgi:Cyan7425_1067 243 YTFYGMIAClglgailLVVG 262 Cyanothece sp. PCC 7425
Q8DMC2            228 KMTYASLGA-------TLCG 240 Synechococcus elongatus
Q8DL39            236 ASIIAAGVF-------SGLG 248 Synechococcus elongatus
WP_015954732      241 GTFYSMIFFltl-gliLLVA 259 Gloeothece citriformis
tgen:AM1_3710     241 YAFYGMIST-------LVVG 253 Acaryochloris marina MBIC11017
Q31N13            242 WLTIGAIASvv---vtVVAA 258 Synechococcus elongatus PCC 7942
WP_012795982      238 LLAITVITSfv----lGWVL 253 Saccharomonospora viridis
Q1ATI9            226 LLGLIALGLf-----lAGAA 240 Rubrobacter xylanophilus DSM 9941
jgi:Sthe_2360     229 WLGISAVALfalavilFVVA 248 Sphaerobacter thermophilus DSM 20745
jgi:Caur_1130     226 NMRYAAIASgv---igLALV 242 Chloroflexus aurantiacus J-10-fl
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