Conserved Protein Domain Family

pfam12465: Pr_beta_C 
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Proteasome beta subunits C terminal
This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam00227. There is a conserved GTT sequence motif. There is a single completely conserved residue Y that may be functionally important. This family includes the C terminal of the beta-type subunits of the proteasome, a multimeric complex that degrades proteins into peptides as part of the MHC class I-mediated Ag-presenting pathway.
PSSM-Id: 403609
View PSSM: pfam12465
Aligned: 102 rows
Threshold Bit Score: 37.7536
Threshold Setting Gi: 194108958
Created: 21-May-2020
Updated: 7-Aug-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
6GOP_V                195 VREEKQKSYKFPRGTTAVLKESIVNICDiqEEQV 228 Saccharomyces cerevisiae S288C
EKD05517              215 ERVHKNRDYKFRRGTTAWLKENV-RDLIasETVH 247 Trichosporon asahii var. asahii CBS 8904
EGG10123              230 ERVPKELSYKMRRGATAWIKHDV-RKLIvdESIT 262 Melampsora larici-populina 98AG31
WGS:AAWC:PGTG_07060.3 236 ERVAKELNYTMRRGTTAWIKQDI-KKLIvsESVT 268 Puccinia graminis f. sp. tritici CRL 75-36-700-3
WGS:AACS:CC1G_05307   231 VRVQKERDYKFRRGTTAWKKEDI-RKLVidEQVT 263 Coprinopsis cinerea okayama7#130
XP_007333729          228 QRVQKERDYKFRRGTTAWTKEDV-RKFVveETVT 260 Agaricus bisporus var. burnettii JB137-S8
XP_007400410          231 ERVEKERHYVFRRGTTAIKSETV-RSLLveETVT 263 Phanerochaete carnosa HHB-10118-sp
XP_014569797          251 ERVQKEMSYKPKLGTTVWKKEMV-KSLIvkTEVI 283 Mixia osmundae IAM 14324
KDE05115              223 QKVDKERSYKWRRGTTAYTKEEV-KYHLvkEEVT 255 Microbotryum lychnidis-dioicae p1A1 Lamole
CAZ84023              223 ERVPKEMSYKFARGTTGYIKEMVVEKKDlkKYVT 256 Perigord truffle
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