Conserved Protein Domain Family
PTP_N

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pfam12453: PTP_N 
Protein tyrosine phosphatase N terminal
This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with pfam00041. There is a single completely conserved residue L that may be functionally important. This family consists of various protein tyrosine phosphatase haematopoietic receptors, e.g. CD45, which dephosphorylate growth stimulating proteins. This limits growth signalling in haematopoietic cells.
Statistics
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PSSM-Id: 403599
View PSSM: pfam12453
Aligned: 4 rows
Threshold Bit Score: 41.3722
Threshold Setting Gi: 121948657
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004013981    7 LKLLAFGFAFLDTAVSVAGNFTGPST 32   sheep
Q0VAE8          5 LKLLAFGFAFLDTEVFVTGQSPTPSP 30   human
ELW57889        7 LKLLAFGFVFLDPEVFVTVESNTSSP 32   Chinese tree shrew
XP_004756284    7 LKLWAFAFAFLDAGVFVTGEDLSSST 32   domestic ferret
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