Conserved Protein Domain Family
Fox-1_C

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pfam12414: Fox-1_C 
Calcitonin gene-related peptide regulator C terminal
This domain family is found in eukaryotes, and is typically between 69 and 99 amino acids in length. The family is found in association with pfam00076. This family is the C terminal of Fox-1, a protein involved in the regulation of calcitonin gene-related peptide to mediate the neuron-specific splicing pattern. Fox-1, with Fox-2, functions to repress exon 4 inclusion.
Statistics
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PSSM-Id: 403573
View PSSM: pfam12414
Aligned: 10 rows
Threshold Bit Score: 64.5728
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005001479 208 VTGFPYPTTG--------TAVAYRGAhLRGRGRA-VYNTFRAAPPPPPIP-------------------TYGAaleqtlv 259 domestic guinea...
XP_008111769 149 VASIPYPMMAp-------AALAYRGA-LRGRGRAtIYNPIRAAPAPSPVP-------------------AYGS------- 194 green anole
6_pfamImport   1 LTGFPYPTAG--------AAVAYRGAhLRGRGRA-VYNTFRAAPPPPPIP-------------------TYGA------- 45 
XP_017729906 202 MPGFPYPAAT--------AAAAYRGAhLRGRGRT-VYNTFRAAAPPPPIP-------------------AYGG------- 246 black snub-nose...
Q642J5       228 VPGFPYPAATa-------AAAAYRGAhLRGRGRT-VYNTFRAAAPPPHIP-------------------AYGG------- 273 zebrafish
5_pfamImport   1 IPGFPYPTAAaa----atTAAAFRGAhLRGRGRT-VYGAVR-AVPPTAIP-------------------TYPG------- 48 
XP_021155111 204 VPGFPYPTAAt-------TAAAFRGAhLRGRGRT-VYGAVR-AVPPTAIP-------------------AYPG------- 248 rock pigeon
XP_015456234 239 VPGFPYPTAAaaa--aatTAATFRGAhLRGRGRP-VYGAVRAAVPQPAIP-------------------AYPG------- 289 Mexican tetra
XP_028841179 249 VPGFPYPTAAaaa---asTAAAFRGAhLRGRGRP-VYSAVRAAVPQPAIP-------------------AYPG------- 298 denticle herring
TNM97588      41 vPGFPYPSAAaattaaaaAAAAFRGAhLRGRGRP-VYSAVRAALPQPAIPaypgvvyqdgfysaadlygGYPA------- 112 Takifugu bimacu...
XP_005001479 260 kmpvpwaglapcplppqqtpepayptspafpplscpfasrVVYQDGF-YG-AE-IYgGY-AAYRYTQ---P----AAAA- 327 domestic guinea...
XP_008111769 195 ----------------------------------------VLYPDGL-YG-SD-IY-GYpAAYRVAQ---T----PAAAa 223 green anole
6_pfamImport  46 ----------------------------------------ILYLDNIaYK-NN-IAgGY-AAYRYAQ---P----AAAA- 74 
XP_017729906 247 ----------------------------------------VVYQEPV-YG-NKlLQgGY-AAYRYAQ---P----TPAT- 275 black snub-nose...
Q642J5       274 ----------------------------------------VVYQDGF-YG-AD-IYgGY-TAYRYTQ---P----ATAT- 301 zebrafish
5_pfamImport  49 ----------------------------------------VLYQDGF-YG-TE-LYgGY-AAYRYTQlpsP----PTSAl 80 
XP_021155111 249 ----------------------------------------VVYQDGF-YG-AD-LYgGY-AAYRYAQ---P----ATATa 277 rock pigeon
XP_015456234 290 ----------------------------------------VVYQDGF-YGpAD-LYgGY-AAYRYAQ---P----TAVAg 319 Mexican tetra
XP_028841179 299 ----------------------------------------VVYQDGF-YG-AAdLYgGY-AAYRYAQ---PaavtGATAa 332 denticle herring
TNM97588     113 ------------------------------------------------AA-AA-AAaAA-AAYRYTQ---P----ATVTg 134 Takifugu bimacu...
XP_005001479 328 -------AAAAAYSDS-YGRVYaAADPY 347 domestic guinea pig
XP_008111769 224 ------aTAAAAYSDG-YGRVYtTAEPY 244 green anole
6_pfamImport  75 ---------ATAYSDS-YGRVYtAADPY 92 
XP_017729906 276 ---------AAAYSDR-NQFVFvAADei 293 black snub-nosed monkey
Q642J5       302 ---------AAAYSDS-YGRVY-AADPY 318 zebrafish
5_pfamImport  81 talpvppLTARMCTDReYGRVY-TADPY 107
XP_021155111 278 at--aaaAAAAAYSDG-YGRVY-TADPY 301 rock pigeon
XP_015456234 320 ptaaaaaAAAAAYSDS-YGRVY-TADPY 345 Mexican tetra
XP_028841179 333 a-----aAAAAAYSDS-YGRVY-TTDPY 353 denticle herring
TNM97588     135 a-----tPAAAAYSDS-YGRVY-TTDPY 155 Takifugu bimaculatus
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