Conserved Protein Domain Family
P5-ATPase

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pfam12409: P5-ATPase 
P5-type ATPase cation transporter
This domain family is found in eukaryotes, and is typically between 110 and 126 amino acids in length. The family is found in association with pfam00122, pfam00702. P-type ATPases comprise a large superfamily of proteins, present in both prokaryotes and eukaryotes, that transport inorganic cations and other substrates across cell membranes.
Statistics
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PSSM-Id: 403569
View PSSM: pfam12409
Aligned: 145 rows
Threshold Bit Score: 61.8061
Threshold Setting Gi: 74778256
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_012060096   62 EEDQME--IYGYRRNHARTVIIWFLIVITGGLLRLIFHWVPHLMLQATHIKCSLEEAETVLLIek-fqGKHTSYYVKKLR 138  Atta cephalotes
XP_022532954   33 SVSHMD--VQGYRRVCWRVWLCRFGAVCSLGMLLVLFNWRPRLAVLARCTSCPLPMADTLLLR-----DIYGQQFVIEVC 105  Mexican tetra
NP_001073506   34 lvsHMD--VQGYRWVCWKVWLCRIGAVFSVGLLLVLFKWRPRIGILARCKSCPISMADVLLLK-----DRYGQQFVVDVI 106  zebrafish
EHB12015       31 SASSVR--LSGYWGSPWRAIGYHAVVWVLAGIPLLLFRWKPSWGVRLRSRPCSLAHAETLVIEtrdkeDSSWQLFTVQVQ 108  naked mole-rat
PNI33425       23 SVSSVR--LSGYCGSPWRVIGYHVVVWMMAGIPLLLFRWKPLWGVRLRLRPCNLAHAETLVIEirdkeDSSWQLFTVQVQ 100  chimpanzee
NP_001157838   31 SASSVR--LSGYCGSPWRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLKPCSLAHAETLVIEikdkeGSSRQLFTVQVQ 108  house mouse
Q5CW06         42 HKFDYPvyITPICRRLYLEKVYLIFQIFTLGIISIICHWFPNFYRWMNFKASTISECDSFLVI-----TKESYYSVVNRN 116  Cryptosporidi...
Q8I3U7         33 RISYIE--CYKKKKKKIVTILHYVFCILSLGLLPLILSWFPIFYFRLLHSACTLNECEKVLII-----TKDGNKYIKKIK 105  Plasmodium fa...
XP_023421508   31 sassVR--LSGYCGSPWRAIGYHAVVWVLAGIPLLLFRWKPLWGVRLRLRPCSLARAETLVIEtr--dKEDSSWQLFTVQ 106  domestic guin...
XP_016160529   47 DTARME--VTGYRRRAWRVLLCHAGSALSAGLLLLLFHWKPSLEVRAKCEPCALGQADWLIIR-----DRFGQCFTTEVL 119  collared flyc...
XP_012060096  139 NVT------AkevINKSFheeslmdDAWDGSVITTK-EEketyamlsvhlfGGQFKqVPSITIFNCKkltyvWD 205  Atta cephalotes
XP_022532954  106 TVEve---------eGSFe-----hAGGEVDENEWRdNV------------QLHKEqKTVLRYYVFEgmryvWM 153  Mexican tetra
NP_001073506  107 TEEve-------eGSLDF-------AVGDADENEWRdTV------------QLHSEkKTLLRYYVFEgiryiWI 154  zebrafish
EHB12015      109 TEAvv-------eGSLELpl---qaEDGRSKVALGAvPEtpwkdtarlhrrEEA---KQVVRYYLFQgrryvWI 169  naked mole-rat
PNI33425      101 TEAig--egS---LEPSPqa---qaEDGRSQAAVGAvPEgawkd---taqlHKSEE-ARVLRYYLFQgqryiWI 162  chimpanzee
NP_001157838  109 TEAvvqgslE---LPPQaq-----aEDGRSQAAVGVtPEgtwqdtselhrqE--EA-KQVLRYYVLQgqryvWM 171  house mouse
Q5CW06        117 KFF------S---LNKNF-----------------SnDE------------------LNLLRFLNILpsqykFS 146  Cryptosporidium parvum
Q8I3U7        106 KIKfn--hnVcyvMNDVF-----------FSEDQSMsSM------------YNDKE--QNKNNFNYFsrdytFR 152  Plasmodium falcipar...
XP_023421508  107 VQTea---iGegsLELPLq-----aEDGRSQVAVGAvPRsvwkd--taqlrRREEA-KRVARYYLFQgrryiWI 169  domestic guinea pig
XP_016160529  120 TEPlg-------eAG-LEqlpgaqqDRRSSVAVAVPdEDesrdt---vqlhDKDE--KSILRYYLFQgmryvca 180  collared flycatcher
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